Definition
Baculovirus IAP repeat (BIR) is a conserved protein domain of approximately 70 amino acids in members of the ‘inhibitor of apoptosis’ (IAP) protein family. BIR was originally identified to suppress apoptosis in baculovirus infected cells of the fruit fly Drosophila melanogaster. In mammalian cells some IAP proteins were identified as inhibitors of caspases, others apparently lack the ability to interact with caspases. It is likely that IAP proteins have also other functions, an indication supported by the fact that IAP proteins exist in yeast, which do not have caspases.
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© 2001 Springer-Verlag
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(2001). Baculovirus IAP Repeat. In: Schwab, M. (eds) Encyclopedic Reference of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30683-8_135
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DOI: https://doi.org/10.1007/3-540-30683-8_135
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-66527-4
Online ISBN: 978-3-540-30683-2
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