Conclusions
We found that under both high and low coagulant challenge clotting time was dosedependently prolonged, thrombin potential and prothrombin fragment 1+2 generation were dose-dependently suppressed in the presence of increasing amounts of rhAPC in both cord and adult plasma.Whereby, cord plasma was significantly more susceptible to addition of rhAPC in the presence of high amounts of TF as trigger for clot formation and adult plasma was significantly more susceptible to addition of rhAPC in the presence of low amounts of TF.Whereas the elevated anticoagulant action of rhAPC in cord plasma under high coagulant challenge might be caused by the low neonatal levels of prothrombin, we demonstrate that the increased anticoagulant efficacy of rhAPC in adult plasma under low coagulant challenge is attributable to the physiologically high levels of TFPI and AT present in adults.
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© 2005 Springer Medizin Verlag Heidelberg
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Cvirn, G. et al. (2005). Comparison of the Anticoagulant Action of Recombinant Human Activated Protein C in Cord with that in Adult Plasma. In: Scharrer, I., Schramm, W. (eds) 34th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27022-1_14
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