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Transitions in Understanding of RNA Viruses: A Historical Perspective

  • Chapter
Quasispecies: Concept and Implications for Virology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 299))

Abstract

This chapter documents that RNA viruses have been known for over a century to be genetically variable. In recent decades, genetic and molecular analyses demonstrate that they form RNA quasispecies populations; the most rapidly mutating, highly variable and genetically versatile life forms on earth. Their enormous populations, rapid replication and extreme genetic plasticity can allow rates of evolution that exceed those of their eukaryotic host populations by millions-fold.

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  1. Division of Biology and Institute for Molecular Genetics, University of California, CA, La Jolla, 92093, USA

    J. J. Holland

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  1. Centro de BiologÍa Molecular “Servero Ochoa” (CSIC-UAM), Universidad Autónoma de Madrid, 28049, Cantoblanco, Madrid, Spain

    Esteban Domingo

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Holland, J.J. (2006). Transitions in Understanding of RNA Viruses: A Historical Perspective. In: Domingo, E. (eds) Quasispecies: Concept and Implications for Virology. Current Topics in Microbiology and Immunology, vol 299. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26397-7_14

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