Summary
The objective of this study was to evaluate the effect of a single photodynamic therapy (PDT) on brain edema and intracranial pressure (ICP) in a rabbit model of brain tumor.
A total of 57 adult New Zealand rabbits were assigned to 3 groups: the PDT group, the tumor group, and the tumor plus PDT group. Rabbits in the PDT group (n = 9) received PDT but no tumor implantation; rabbits in the tumor group (n = 18) received VX2 carcinoma implantation but no PDT; rabbits in the tumor plus PDT group (n = 30) received tumor implantation with subsequent PDT 16 days later.
Brain edema and ICP levels were then evaluated. We found that ICP in the PDT group was 7.43 ± 50 mmHg. After tumor implantation, ICP increased rapidly (18.43 ± 1.10 mmHg, 21 days later). PDT alone did not increase ICP, but compared with that in the tumor group, ICP increased significantly in the tumor plus PDT group (9.55± 1.32 vs. 13.31 ± 1.13 mmHg, p < 0.01) 24 hours after treatment. Brain water content in the tumor group increased rapidly after tumor implantation. PDT again increased perineoplastic brain edema 24 hours after treatment (81.09 ± 0.97% vs. 78.32 ± 0.49%, p < 0.01). It should be noted that PDT alone did not induce brain edema.
In conclusion, PDT causes transient brain edema and increases ICP in a rabbit brain tumor model.
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Li, F. et al. (2006). Photodynamic therapy increases brain edema and intracranial pressure in a rabbit brain tumor model. In: Hoff, J.T., Keep, R.F., Xi, G., Hua, Y. (eds) Brain Edema XIII. Acta Neurochirurgica Supplementum, vol 96. Springer, Vienna. https://doi.org/10.1007/3-211-30714-1_87
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DOI: https://doi.org/10.1007/3-211-30714-1_87
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