Abstract
The synovial membrane is a limited space in the human body, yet therein can arise a variety of benign, intermediate, and malignant soft tissue and bone tumors. Each of these tumors shows different and in some instances unique histomorphologic features that help to recognize and differentiate them from other tumor types. Their molecular profile has also been extensively analyzed, and specific driver ontogenetic mechanisms have been described, establishing their neoplastic nature. The only true primary neoplasms of the synovium are fibroma of the tendon sheath and tenosynovial giant cell tumor. In very rare instances, other tumor types can also primarily arise in synovium, presumably from cells that are located or circulated within the synovial membrane, like endothelial cells, adipose cells, and cells of lymphopoietic origin. Synovium can also be a site of metastatic disease involvement. In all instances, a multidisciplinary team approach where history, clinical, radiological, and pathological image, accompanied by molecular testing, will be discussed is the key to the correct diagnosis.
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Siozopoulou, V. (2023). Pathology, Genetics, and Molecular Biology. In: Vanhoenacker, F.M., Ladeb, M.F. (eds) Imaging of Synovial Tumors and Tumor-like Conditions. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2023_409
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