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Liver Radioembolization with 90Y Microspheres pp 119–127Cite as

HCC. Radioembolization Combined with Other Therapeutic Local and Systemic Treatment

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Only in early stages of HCC resection, local ablative therapy, and transplantation are offering a chance of cure, whereas only a minority of patient will amenable for such a therapy. The majority of patients are presenting an intermediate or even advanced tumor stages where the therapeutic options are limited to transarterial and systemic molecular therapies. Radio embolization may augment the therapeutic armamentarium particularly in patients just not meeting the criteria for resection, percutaneous ablation or transplantation by downsizing/downgrading or in progressed disease where transarterial chemotherapy is contraindicated. Recent results of radio embolization in these settings and future directions will be discussed.

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Abbreviations

AASLD:

American Association for the Study of Liver Diseases

BCLC:

Barcelona-Clinic Liver Cancer

BSC:

Best supportive care

C-B:

Child-Pugh

CR:

Complete response

EASL:

European Association for the Study of the Liver

ECOG:

Eastern Cooperative Oncology Group

ENRY:

European Network on Radioembolization with Yttrium-90 Resin Microspheres

EORTC:

European Organization for Research and Treatment of Cancer

ESMO:

European Society for Medical Oncology

Gd-EOB-DTPA:

Gadoxetic acid (Promovist®, Bayer, Germany)

LTx:

Liver transplantation

NCCN:

National Comprehensive Cancer Network

NCI:

National Cancer Institute

PR:

Partial response

PVT:

Portal-vein thrombosis

RE:

Radio-embolization

Rx:

Resection

SD:

Stable disease

SHARP:

Sorafenib HCC Assessment Randomized Protocol

TACE:

Transarterial chemo-embolization

TAE:

Transarterial embolization

TTP:

Time to progression

UNOS:

United Network for Organ Sharing

VT:

Venous thrombosis

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Authors and Affiliations

  1. Institute of Diagnostic and Interventional Radiology, Neuroradiology and Nuclear Medicine, Klinikum Bogenhausen, Englschalkinger Str. 77, 81925, Munich, Germany

    Thomas Helmberger

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  1. Thomas Helmberger
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Correspondence to Thomas Helmberger .

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  1. Departamento de Radiología, Clínica Universidad de Navarra, Pamplona, Spain

    José Ignacio Bilbao

  2. Institut für Klinische Radiologie, Universitätsklinikum München Klinikum Großhadern, München, Germany

    Maximilian F Reiser

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Helmberger, T. (2013). HCC. Radioembolization Combined with Other Therapeutic Local and Systemic Treatment. In: Bilbao, J., Reiser, M. (eds) Liver Radioembolization with 90Y Microspheres. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2013_821

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