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Radionuclide Therapy for Bleeding Joints in Hemophilia

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Therapeutic Nuclear Medicine

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Radiosynovectomy is the local intraarticular injection of radionuclides (Yttrium–90, Rhenium-186, P-32, Erbium-169), which are thought to be rapidly phagocytosed by synoviocytes, and then distributed within the surface of the synovium causing vasculitis and occluding the microvascular supply. This, in addition to the cytotoxic effect of radiation, results in ablation of the synovium. This procedure needs only 30 % coagulopathy among hemophilics. With the overall improvement of 80−92% in most studies, it must be the procedure of choice for hemophilics with repeated bleeding and in those where surgery cannot be done. It should be considered for hemophilics with joint disease not responsive to replacement therapy and for those whom surgical synovectomy pose too many risks.

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Authors and Affiliations

  1. Department of Nuclear Medicine and PET, St. Luke’s Medical Center, Cathedral Heights, Quezon City, 1100, Philippines

    Emerita Andres-Barrenechea

  2. Department of Pediatrics, Cardinal Santos Medical Center, ., ., ., .

    Mary Chua

  3. Rheumatology Section, St. Luke’s Medical Center, ., ., ., .

    Sandra Navarra

Authors
  1. Emerita Andres-Barrenechea
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  2. Mary Chua
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  3. Sandra Navarra
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Corresponding author

Correspondence to Emerita Andres-Barrenechea .

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Editors and Affiliations

  1. THERANOSTICS Center for Molecular, Radiotherapy and Molecular Imaging, ENETS Center of Excellence, Bad Berka, Germany

    Richard P. Baum

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© 2012 Springer-Verlag Berlin Heidelberg

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Andres-Barrenechea, E., Chua, M., Navarra, S. (2012). Radionuclide Therapy for Bleeding Joints in Hemophilia. In: Baum, R. (eds) Therapeutic Nuclear Medicine. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_676

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  • DOI: https://doi.org/10.1007/174_2012_676

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-36718-5

  • Online ISBN: 978-3-540-36719-2

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