Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery

Carneiro, Simone; Müller, Joschka T.; Merkel, Olivia M.

doi:10.1007/164_2023_703

Simone Carneiro¹¹^na1,
Joschka T. Müller¹¹^na1 &
Olivia M. Merkel^11,12,13^na1

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 284))

145 Accesses

Abstract

Respiratory diseases are a major concern in public health, impacting a large population worldwide. Despite the availability of therapies that alleviate symptoms, selectively addressing the critical points of pathopathways remains a major challenge. Innovative formulations designed for reaching these targets within the airways, enhanced selectivity, and prolonged therapeutic effects offer promising solutions. To provide insights into the specific medical requirements of chronic respiratory diseases, the initial focus of this chapter is directed on lung physiology, emphasizing the significance of lung barriers. Current treatments involving small molecules and the potential of gene therapy are also discussed. Additionally, we will explore targeting approaches, with a particular emphasis on nanoparticles, comparing targeted and non-targeted formulations for pulmonary administration. Finally, the potential of inhaled sphingolipids in the context of respiratory diseases is briefly discussed, highlighting their promising prospects in the field.

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Abbreviations

API:: Active pharmaceutical ingredient
CA-IX:: Carbonic anhydrase IX
CF:: Cystic fibrosis
COPD:: Chronic obstructive pulmonary disease
DOTAP:: 1,2-Dioleoyl-3-trimethylammonium-propane
DPPC:: Dipalmitoyl phosphatidylcholine
DSPE:: 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine
FA:: Folic acid
FR:: Folic acid receptor
KRAS:: Kirsten rat sarcoma
LNP:: Lipid nanoparticle
MCC:: Mucociliary clearance
MMAD:: Mass median aerodynamic diameter
NHS:: N-hydroxysuccinimide
PCLS:: Precision-cut lung slices
PEG:: Polyethylene glycol
PEI:: Polyethyleneimine
PLGA:: Poly(lactic-co-glycolic acid)
SP:: Surfactant protein
Tf:: Human holo-transferrin
TSLP:: Thymic stromal lymphopoietin
VIPER:: Virus-inspired polymer for endosomal release

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Simone Carneiro and Joschka T. Müller contributed equally to this work.

Authors and Affiliations

Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-University Munich, Munich, Germany
Simone Carneiro, Joschka T. Müller & Olivia M. Merkel
Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich, Munich, Germany
Olivia M. Merkel
Institute of Lung Health and Immunity (LHI) and Comprehensive Pneumology Center (CPC) with the CPC-M bioArchive, Helmholtz Munich, German Center for Lung Research (DZL), Munich, Germany
Olivia M. Merkel

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Simone Carneiro
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Joschka T. Müller
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Correspondence to Olivia M. Merkel .

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Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany
Monika Schäfer-Korting
Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Jena, Germany
Ulrich S. Schubert

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Carneiro, S., Müller, J.T., Merkel, O.M. (2024). Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery. In: Schäfer-Korting, M., Schubert, U.S. (eds) Drug Delivery and Targeting. Handbook of Experimental Pharmacology, vol 284. Springer, Cham. https://doi.org/10.1007/164_2023_703

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