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Insights from Studies of White Adipose Tissue Using Single-Cell Approaches

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From Obesity to Diabetes

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 274))

Abstract

Technologies allowing studies at single-cell resolution have provided important insights into how different cell populations contribute to tissue function. Application of these methods to white adipose tissue (WAT) has revealed how various metabolic aspects of this organ, such as insulin response, inflammation and tissue expansion, are regulated by specific WAT resident cells, including different subtypes of adipocytes, adipocyte progenitors as well as immune and endothelial cells. In this chapter, we provide an overview of the different technical approaches, their strengths and weaknesses, and summarize how these studies have improved our understanding of WAT function in health and disease.

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Authors and Affiliations

  1. Department of Medicine (H7), Karolinska Institute, Stockholm, Sweden

    Niklas Mejhert & Mikael Rydén

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  1. Niklas Mejhert
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  2. Mikael Rydén
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Correspondence to Niklas Mejhert or Mikael Rydén .

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  1. Institute for Clinical Diabetology, German Diabetes Center, DĂĽsseldorf, Germany

    Juergen Eckel

  2. NutriOmique Research group, Nutrition Department, Pitié-Salpêtrière Hospital, APHP, Sorbonne Université/INSERM, Paris, France

    Karine Clément

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Mejhert, N., Rydén, M. (2022). Insights from Studies of White Adipose Tissue Using Single-Cell Approaches. In: Eckel, J., Clément, K. (eds) From Obesity to Diabetes. Handbook of Experimental Pharmacology, vol 274. Springer, Cham. https://doi.org/10.1007/164_2021_578

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