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The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias

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Reviews of Physiology, Biochemistry and Pharmacology, Vol. 172

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 172))

Abstract

Stress-response kinases, the mitogen-activated protein kinases (MAPKs) are activated in response to the challenge of a myriad of stressors. c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinases (ERKs), and p38 MAPKs are the predominant members of the MAPK family in the heart. Extensive studies have revealed critical roles of activated MAPKs in the processes of cardiac injury and heart failure and many other cardiovascular diseases. Recently, emerging evidence suggests that MAPKs also promote the development of cardiac arrhythmias. Thus, understanding the functional impact of MAPKs in the heart could shed new light on the development of novel therapeutic approaches to improve cardiac function and prevent arrhythmia development in the patients. This review will summarize the recent findings on the role of MAPKs in cardiac remodeling and arrhythmia development and point to the critical need of future studies to further elucidate the fundamental mechanisms of MAPK activation and arrhythmia development in the heart.

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Abbreviations

AERP:

Atrial effective refractory period

AF:

Atrial fibrillation

APD:

Action potential duration

Ca2+ :

Calcium

CABG:

Coronary artery bypass graft

CaMKII:

Calcium/calmodulin dependent protein kinase II

CDC42:

Cell division protein 42 homolog

CL:

Cycle length

CVD:

Cardiovascular disease

DAD:

Delayed afterdepolarizations

EAD:

Early afterdepolarizations

Egr-1:

Early growth response protein

ERK:

Extracellular signal regulated kinase

HF:

Heart failure

HL-1:

Mouse atrial myocyte line from Louisiana State University

I/R:

Ischemia reperfusion

ICa:

L-type calcium channel

JNK:

c-Jun N-terminal kinase

LA:

Left atrium

LAD:

Left anterior descending

MAPK:

Mitogen-activated protein kinase

MI:

Myocardial infarction

MKK:

Mitogen-activated protein kinase kinase

NCX:

Sodium calcium exchange channel

p38:

Member of MAPK family

PLB:

Phospholamban

Pro:

Proline amino acid residue

Rac1:

Ras-related C3 botulinum toxin substance 1

RyR:

Calcium-triggered calcium release channel

Ser:

Serine amino acid residue

SERCA:

Sarcoplasmic reticulum calcium ion-ATPase

SP-1:

Transcription factor SP-1

SR:

Sarcoplasmic reticulum

TAC:

Transverse aortic constriction

Thr-Gly-Tyr:

Threonine, glycine, tyrosine amino acid sequence

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Acknowledgments

This work was supported by National Institutes of Health (R01HL113640 to XA).

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The author has no disclosures.

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Authors and Affiliations

  1. Department of Molecular Biophysics and Physiology, Rush University Medical Center, 1750 W Harrison St, Chicago, IL, 60612, USA

    Xun Ai, Jiajie Yan, Elena Carrillo & Wenmao Ding

Authors
  1. Xun Ai
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  2. Jiajie Yan
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  3. Elena Carrillo
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  4. Wenmao Ding
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Corresponding author

Correspondence to Xun Ai .

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Editors and Affiliations

  1. KU Leuven, Leuven, Belgium

    Bernd Nilius

  2. Cardiovascular Research Center, Loyola University Chicago, Maywood, Illinois, USA

    Pieter de Tombe

  3. Walther-Straub-Institut für Pharmakologie und Toxikologie, Munich, Bayern, Germany

    Thomas Gudermann

  4. Department of Neurobiology, Max-Planck-Institute, Göttingen, Niedersachsen, Germany

    Reinhard Jahn

  5. Department of Cytobiology, University of Marburg, Marburg, Germany

    Roland Lill

  6. Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom

    Ole H. Petersen

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© 2016 Springer International Publishing Switzerland

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Ai, X., Yan, J., Carrillo, E., Ding, W. (2016). The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias. In: Nilius, B., de Tombe, P., Gudermann, T., Jahn, R., Lill, R., Petersen, O. (eds) Reviews of Physiology, Biochemistry and Pharmacology, Vol. 172. Reviews of Physiology, Biochemistry and Pharmacology, vol 172. Springer, Cham. https://doi.org/10.1007/112_2016_8

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