Skip to main content

Local Anesthetic Pharmacology

  • Chapter
Obstetric Anesthesia Handbook

Abstract

Local anesthetics are an integral part of obstetric anesthesia; hence an adequate knowledge of these chemical agents is absolutely essential.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. McClure JH: Ropivacaine. Br J Anaesth 1996; 76:300.

    PubMed  CAS  Google Scholar 

  2. Nath S, Johansson G, Haggmark S, Reizs: Cardiotoxicity of ropivacaine—a new amide local anaesthetic agent. Acta Anaesthesiol Scand 1989; 33:93.)

    PubMed  Google Scholar 

  3. Covino BG, Vassallo HG: Mechanisms of action and clinical use. In Local Anesthetics. New York, Grune & Stratton, 1976.

    Google Scholar 

  4. Finster M: Toxicity of local anesthetics in the fetus and the newborn. Bull N Y Acad Med 1976; 52:222.

    PubMed  CAS  Google Scholar 

  5. Littlewood DG, Buckley P, Covino BG, et al: Comparative study of various local anesthetic solutions in extradural block in labour. Br J Anaesth 1979; 51:47.

    Article  Google Scholar 

  6. Crawford OB: Comparative evaluation in peridural anesthesia of lidocaine, mepivacaine and L-67, a new local anesthetic agent. Anesthesiology 1964; 25:321.

    Article  PubMed  CAS  Google Scholar 

  7. DiFazio CA, Carron H, Gosslight KR, et al: Comparison pH-adjusted lidocaine solutions for epidural anesthesia. Anesth Analg 1986; 65:760.

    Article  PubMed  CAS  Google Scholar 

  8. Peterfreund RA, Datta S, Ostheimer GW: pH adjustment of local anesthetic solutions with sodium bicarbonate: Laboratory evaluation of alkalinization and precipitation. Regional Anesth 1989; 1:265.

    Google Scholar 

  9. Catchlove RFH: The influence of CO2 and pH on local anesthetic action. J Pharmacol Exp Ther 1972; 181:291.

    Google Scholar 

  10. Chantigian RC, Datta S, Berger GA, et al: Anesthesia for cesarean delivery using spinal anesthesia: Tetracaine versus tetracaine and procaine. Reg Anaesth 1984; 9:195.

    Google Scholar 

  11. Corke BC, Carlson CG, Dettbarn WD: The influence of 2-chloroprocaine on the subsequent analgesic potency of bupivacaine. Anesthesiology 1984; 60:25.

    Article  PubMed  CAS  Google Scholar 

  12. Fargraeus L, Urban BJ, Bromage PR: Spread of epidural analgesia in early pregnancy. Anesthesiology 1983; 58:184.

    Article  Google Scholar 

  13. Datta S, Hurley RJ, Naulty JS, et al: Plasma and cerebrospinal fluid progesterone concentrations in pregnant and nonpregnant women. Anesth Analg 1986; 65:950.

    Article  PubMed  CAS  Google Scholar 

  14. Datta S, Lambert DH, Gregus J, et al: Differential sensitivities of mammalian nerve fibers during pregnancy. Anesth Analg 1983; 62:1070.

    Article  PubMed  CAS  Google Scholar 

  15. Flanagan HL, Datta S, Lambert DH, et al: Effect of pregnancy on bupivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 1987; 66:123.

    Article  PubMed  CAS  Google Scholar 

  16. Flanagan HL, Datta S, Moller RA, et al: Effect of exogenously administered progesterone on susceptibility of rabbit vagus nerves to bupivacaine (abstract). Anesthesiology 1988; 69:676.

    Article  Google Scholar 

  17. Bader AM, Datta S, Moller RA, et al: Effect of acute progesterone treatment on bupivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 1990; 71:545.

    Article  PubMed  CAS  Google Scholar 

  18. Mehta PM, Theriot E, Mehrotra D: A simple technique to make bupivacaine a rapid-acting epidural anesthetic. Reg Anaesth 1987; 123:135.

    Google Scholar 

  19. Owen MD, Thomas JA, Smith T, et al: Ropivacaine 0.075% and bupivacaine 0.075% with fentanyl 2mcg/ml are equivalent for labor epidural analgesia. Anesth Analg 2002; 94:179.

    Article  PubMed  CAS  Google Scholar 

  20. Datta S: Pharmacology of Local Anesthetic Agents. American Society of Anesthesiologists, Philadelphia, JB Lippincott, 1993; 21:241.

    Google Scholar 

  21. Capogna G, Celleno D, Fusco P, et al: Relative potencies of bupivacaine and ropivacaine for analgesia in labour. Br J. Anaesth 1999; 82:371.

    PubMed  CAS  Google Scholar 

  22. Bader AM, Datta S, Flanagan HL, et al: Comparison of bupivacaine and ropivacaine induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 1989; 68:724.

    Article  PubMed  CAS  Google Scholar 

  23. Polley LS, Columb MO, Naughton NN: Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor. Implications for therapeutic indexes. Anesthesiology 1999; 90:9444.

    Article  Google Scholar 

  24. Campbell DC, Rhonda Z, Crone LL: Ambulatory labor epidural analgesia: Bupivacaine versus ropivacaine. Anesth Analg 2000; 90:1384.

    Article  PubMed  CAS  Google Scholar 

  25. Halperin SH, Walsh V: Epidural Ropivacaine versus bupivacaine for labor: A meta-analysis. Anesth Analg 2003; 93:1473.

    Article  CAS  Google Scholar 

  26. Lacassie HJ, Columb MO: The relative motor blocking potencies of bupivacaine and levobupivacaine in labor. Anesth Analg 2003; 98:1509.

    Article  CAS  Google Scholar 

  27. Gristwood RW, Greaves L: Levobupivacaine: A new safer long acting local anesthetic agent. Expert Opin Invest Drug 1999; 8:861.

    Article  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

(2006). Local Anesthetic Pharmacology. In: Obstetric Anesthesia Handbook. Springer, New York, NY. https://doi.org/10.1007/0-387-31529-2_2

Download citation

  • DOI: https://doi.org/10.1007/0-387-31529-2_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-26075-4

  • Online ISBN: 978-0-387-31529-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics