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Neuronal Plasticity and Seizure Spread in the Entorhinal Cortex and Hippocampus of Amygdala Kindled Rats

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Synaptic Plasticity and Transsynaptic Signaling
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8. References

  • Alle H, Jonas P, Geiger JR (2001) PTP and LTP at a hippocampal mossy fiber-interneuron synapse. Proc Natl Acad Sci U S A 98: 14708–14713.

    Article  PubMed  CAS  Google Scholar 

  • Behr J, Gebhardt C, Heinemann U, Mody I (2002) Kindling enhances kainate receptor-mediated depression of GABAergic inhibition in rat granule cells. Eur J Neurosci 16: 861–867.

    Article  PubMed  Google Scholar 

  • Behr J, Gloveli T, Guitérrez R, Heinemann U (1996) Spread of low Mg2+ induced epileptiform activity from the rat entorhinal cortex to the hippocampus after kindling studied in vitro. Neurosci Lett 216: 41–44.

    PubMed  CAS  Google Scholar 

  • Behr J, Heinemann U, Mody I (2000a) Glutamate receptor activation in the kindled dentate gyrus. Epilepsia 41: S100–S103.

    Article  PubMed  Google Scholar 

  • Behr, J., Heinemann, U., and Mody, I. Kindling induces transient NMDA receptor-mediated facilitation of high frequency input in the rat dentate gyrus. 2000b.

    Google Scholar 

  • Behr J, Lyson KJ, Mody I (1998) Enhanced propagation of epileptiform activity through the kindled dentate gyrus. J Neurophysiol 79: 1726–1732.

    PubMed  CAS  Google Scholar 

  • Bogerts, B. The neuropathology of schizophrenic diseases: historical aspects and present knowledge. Eur. Arch. Psychiatry Clin. Neurosci. 249Suppl 4, 2–13, 2002.

    Google Scholar 

  • Bohlen HO, Schulze K, Albrecht D (2004) Amygdala-kindling induces alterations in neuronal density and in density of degenerated fibers. Hippocampus 14: 311–318.

    Article  Google Scholar 

  • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol Berl 82: 239–259.

    Article  PubMed  CAS  Google Scholar 

  • Buchheim K, Schuchmann S, Siegmund H, Gabriel H-J, Heinemann U, Meierkord H (1999) Intrinsic optical signal measurement reveal characteristic features during different forms of spontaneous neuronal hyperactivity associated with ECS shrinkage in vitro. Eur J Neurosci 11: 1877–1882.

    Article  PubMed  CAS  Google Scholar 

  • Buckmaster PS, Schwartzkroin PA (1995) Interneurons and inhibition in the dentate gyrus of the rat in vivo. J Neurosci 15: 774–789.

    PubMed  CAS  Google Scholar 

  • Buhl DL, Harris KD, Hormuzdi SG, Monyer H, Buzsaki G (2003) Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo. J Neurosci 23: 1013–1018.

    PubMed  CAS  Google Scholar 

  • Buhl EH, Otis TS, Mody I (1996) Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science 271: 369–373.

    PubMed  CAS  Google Scholar 

  • Buzsaki G (1986) Hippocampal sharp waves: their origin and significance. Brain Res 398: 242–252.

    Article  PubMed  CAS  Google Scholar 

  • Buzsaki G (2002) Theta oscillations in the hippocampus. Neuron 33: 325–340.

    Article  PubMed  CAS  Google Scholar 

  • Buzsáki G, Haas HL, Anderson EG (1987) Long-term potentiation induced by physiologically relevant stimulus patterns. Brain Res 435: 331–333.

    Article  PubMed  Google Scholar 

  • Chrobak JJ, Buzsáki G (1996) High-frequency oscillations in the output networks of the hippocampalentorhinal axis of the freely behaving rat. J Neurosci 16: 3056–3066.

    PubMed  CAS  Google Scholar 

  • Colgin LL, Kubota D, Jia Y, Rex CS, Lynch G (2004) Long-term potentiation is impaired in rat hippocampal slices that produce spontaneous sharp waves. J Physiol 558: 953–961.

    Article  PubMed  CAS  Google Scholar 

  • Dahl D, Burgard EC, Sarvey JM (1990) NMDA receptor antagonists reduce medial, but not lateral, perforant path-evoked EPSPs in dentate gyrus of rat hippocampal slice. Exp Brain Res 83: 172–177.

    Article  PubMed  CAS  Google Scholar 

  • Dragoi G, Harris KD, Buzsaki G (2003) Place representation within hippocampal networks is modified by long-term potentiation. Neuron 39: 843–853.

    Article  PubMed  CAS  Google Scholar 

  • Dreier JP, Heinemann U (1991) Regional and time dependent variations of low magnesium induced epileptiform activity in rat temporal cortex. Exp Brain Res 87: 581–596.

    Article  PubMed  CAS  Google Scholar 

  • Du F, Eid T, Lothman EW, Köhler C, Schwarcz R (1995) Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J Neurosci 15: 6301–6313.

    PubMed  CAS  Google Scholar 

  • Du F, Whetsell WO, Jr., Abou-Khalil B, Blumenkopf B, Lothman EW, Schwarcz R (1993) Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res 16: 223–233.

    Article  PubMed  CAS  Google Scholar 

  • Dugladze T, Heinemann U, Gloveli T (2001) Entorhinal cortex projection cells to the hippocampal formation in vitro. Brain Res 905: 224–231.

    Article  PubMed  CAS  Google Scholar 

  • Eichenbaum H (1999) The hippocampus: The shock of the new. Curr Biol 9: R482–R484.

    Article  PubMed  CAS  Google Scholar 

  • Empson RM, Heinemann U (1995) The perforant path projection to hippocampal area CAI in the rat hippocampal-cntorhinal cortcx combined slicc. J Physiol (Lond) 484: 707–729.

    PubMed  CAS  Google Scholar 

  • Erchova I, Kreck G, Heinemann U, Herz A (2004) Dynamics of rat entorhinal cortex layer II/III cells: characteristics of membrane potential resonance at rest predict oscillation properties near threshold. J Physiol.

    Google Scholar 

  • Fisahn A, Pike FG, Buhl EH, Paulsen O (1998) Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro. Nature 394: 186–189.

    Article  PubMed  CAS  Google Scholar 

  • Fleidervish IA, Binshtok AM, Gutnick MJ (1998) Functionally distinct NMDA receptors mediate horizontal connectivity within layer 4 of mouse barrel cortex. Neuron 21: 1055–1065.

    Article  PubMed  CAS  Google Scholar 

  • Friedl M, Clusmann H, Kral T, Dietrich D, Schramm J (1999) Analysing metabotropic glutamate group III receptor mediated modulation of synaptic transmission in the amygdala-kindled dentate gyrus of the rat. Brain Res 821: 117–123.

    Article  PubMed  CAS  Google Scholar 

  • Gloveli T, Behr J, Dugladze T, Kokaia Z, Kokaia M, Heinemann U (2003) Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex. Neurobiology of Disease 13: 203–212.

    Article  PubMed  CAS  Google Scholar 

  • Gloveli T, Egorov AV, Schmitz D, Heinemann U, Müller W (1999) Carbachol-induced changes in excitability and [Ca2+]i signalling in projection cells of medial entorhinal cortex layers II and III. Eur J Neurosci 11: 3626–3636.

    Article  PubMed  CAS  Google Scholar 

  • Gloveli T, Schmitz D, Empson RM, Heinemann U (1997a) Frequency-dependent information flow from the entorhinal cortex to the hippocampus. J Neurophysiol 78: 3444–3449.

    PubMed  CAS  Google Scholar 

  • Gloveli T, Schmitz D, Heinemann U (1997b) Prolonged inhibitory potentials in layer III projection cells of the rat medial entorhinal cortex induced by synaptic stimulation in vitro. Neuroscience 80: 119–131.

    Article  PubMed  CAS  Google Scholar 

  • Gloveli T, Schmitz D, Heinemann U (1998) Interaction between superficial layers of the entorhinal cortex and the hippocampus in normal and epileptic temporal lobe. Epilepsy Res 32: 183–193.

    Article  PubMed  CAS  Google Scholar 

  • Gutierrez R (2002) Activity-dependent expression of simultaneous glutamatergic and GABAergic neurotransmission from the mossy fibers in vitro. J Neurophysiol 87: 2562–2570.

    PubMed  CAS  Google Scholar 

  • Gutierrez R, Heinemann U (2001) Kindling induces transient fast inhibition in the dentate gyrus-CA3 projection. Eur J Neurosci 13: 1371–1379.

    Article  PubMed  CAS  Google Scholar 

  • Heinemann U, Beck H, Dreier JP, Ficker E, Stabel J, Zhang CL (1992) The dentate gyrus as a regulated gate for the propagation of epileptiform activity. In: The dentate gyrus and its role in seizures (Ribak CE, Gall CM, Mody I, eds), pp 273–280. Amsterdam: Elsevier Science Publishers BV.

    Google Scholar 

  • Heinemann U, Schmitz D, Eder C, Gloveli T (2000) Properties of entorhinal cortex projection cells to the hippocampal formation. Ann N Y Acad Sci 911: 112–126.

    Article  PubMed  CAS  Google Scholar 

  • Hinz B, Becher A, Mitter D, Schulze K, Heinemann U, Draguhn A, Ahnert-Hilger G (2001) Activity-dependent changes of the presynaptic synaptophysin-synaptobrevin complex in adult rat brain. Eur J Cell Biol 80: 615–619.

    Article  PubMed  CAS  Google Scholar 

  • Jefferys JGR, Traub RD, Whittington MA (1996) Neuronal networks for induced ‘40 Hz’ rhythms. Trends Neurosci 19: 202–208.

    Article  PubMed  CAS  Google Scholar 

  • Jensen K, Chiu CS, Sokolova I, Lester HA, Mody I (2003) GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. J Neurophysiol 90: 2690–2701.

    Article  PubMed  CAS  Google Scholar 

  • Klink R, Alonso A (1997) Muscarinic modulation of the oscillatory and repetitive firing properties of entorhinal cortex layer II neurons. J Neurophysiol 77: 1813–1828.

    PubMed  CAS  Google Scholar 

  • Kullmann DM (2001) Presynaptic kainate receptors in the hippocampus: slowly emerging from obscurity. Neuron 32: 561–564.

    Article  PubMed  CAS  Google Scholar 

  • Lamas M, Gomez-Lira G, Gutierrez R (2001) Vesicular GABA transporter mRNA expression in the dentate gyrus and in mossy fiber synaptosomes. Brain Res Mol Brain Res 93: 209–214.

    Article  PubMed  CAS  Google Scholar 

  • Maier N, Nimmrich V, Draguhn A (2003) Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices. J Physiol 550: 873–887.

    Article  PubMed  CAS  Google Scholar 

  • Mody I, Heinemann U (1987) NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling. Nature 326: 701–704.

    Article  PubMed  CAS  Google Scholar 

  • Mody I, Stanton PK, Heinemann U (1988) Activation of N-methyl-D-aspartate receptors parallels changes in cellular and synaptic properties of dentate gyrus granule cells after kindling. J Neurophysiol 59: 1033–1054.

    PubMed  CAS  Google Scholar 

  • Nicoll RA (2003) Expression mechanisms underlying long-term potentiation: a postsynaptic view. Philos Trans R Soc Lond [Biol] 358: 721–726.

    Article  CAS  Google Scholar 

  • Nusser Z, Mody I (2002) Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J. Neurophysiol 87: 2624–2628.

    PubMed  CAS  Google Scholar 

  • Oliver MW, Miller JJ (1985) Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy. Exp Brain Res 57: 443–447.

    Article  PubMed  CAS  Google Scholar 

  • Otis TS, Mody I (1993) Three mechanisms for increased GABAergic inhibition after kindling-induced epilepsy. Soc Neurosci Abstr 19: 1267.

    Google Scholar 

  • Paulsen O, Sejnowski TJ (2000) Natural patterns of activity and long-term synaptic plasticity. Curr Opin Neurobiol 10: 172–179.

    Article  PubMed  CAS  Google Scholar 

  • Poschel B, Draguhn A, Heinemann U (2002) Glut amate-induced gamma oscillations in the dentate gyrus of rat hippocampal slices. Brain Res 938: 22–28.

    Article  PubMed  CAS  Google Scholar 

  • Poschel B, Heinemann U, Draguhn A (2003) High frequency oscillations in the dentate gyrus of rat hippocampal slices induced by tetanic stimulation. Brain Res 959: 320–327.

    Article  PubMed  CAS  Google Scholar 

  • Rausche G, Sarvey JM, Heinemann U (1989) Slow synaptic inhibition in relation to frequency habituation in dentate granule cells of rat hippocampal slices. Exp Brain Res 78: 233–242.

    Article  PubMed  CAS  Google Scholar 

  • Schmitz D, Mellor J, Breustedt J, Nicoll RA (2003) Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat Neurosci 6: 1058–1063.

    Article  PubMed  CAS  Google Scholar 

  • Schousboe A, Bachevalier J, Braak H, Heinemann U, Nitsch R, Schröder H, Wetmore C (1993) Structural correlates and cellular mechanisms in entorhinal-hippocampal dysfunction. Hippocampus 3 Suppl.: 293–302.

    PubMed  Google Scholar 

  • Schreiber S, Erchova I, Heinemann U, Herz AV (2004) Subthreshold resonance explains the frequency-dependent integration of periodic as well as random stimuli in the entorhinal cortex. J Neurophysiol 92: 408–415.

    Article  PubMed  Google Scholar 

  • Schwarzer C, Sperk G (1995) Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat. Neuroscience 69: 705–709.

    Article  PubMed  CAS  Google Scholar 

  • Seiffert E, Dreier JP, Ivens S, Bechmann I, Tomkins O, Heinemann U, Friedman A (2004) Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J Neurosci 24: 7829–7836.

    Article  PubMed  CAS  Google Scholar 

  • Sloviter RS, Dichter MA, Rachinsky TL, Dean E, Goodman JH, Sollas AL, Martin DL (1996) Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus. J Comp Neurol 373: 593–618.

    Article  PubMed  CAS  Google Scholar 

  • Soltesz I, Smetters DK, Mody I (1995) Tonic inhibition originates from synapses close to the soma. Neuron 14: 1273–1283.

    Article  PubMed  CAS  Google Scholar 

  • Squire LR, Alvarez P (1995) Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr Opin Neurobiol 5: 169–177.

    Article  PubMed  CAS  Google Scholar 

  • Stanton PK, Jones RSG, Mody I, Heinemann U (1987) Epileptiform activity induced by lowering extracellular [Mg2+] in combined hippocampal-entorhinal cortex slices: modulation by receptors for norepinephrine and N-methyl-D-aspartate. Epilepsy Res 1: 53–62.

    Article  PubMed  CAS  Google Scholar 

  • Stanton PK, Mody I, Heinemann U (1989) A role for N-methyl-D-aspartate receptors in norepinephrine-induced long-lasting potentiation in the dentate gyrus. Exp Brain Res 77: 517–530.

    Article  PubMed  CAS  Google Scholar 

  • Stanton PK, Sarvey JM (1985a) Depletion of norepinephrine, but not serotonin, reduces long-term potentiation in the dentate gyrus of rat hippocampal slices. J Neurosci 5: 2169–2176.

    PubMed  CAS  Google Scholar 

  • Stanton PK, Sarvey JM (1985b) The effect of high-frequency electrical stimulation and norepinephrine on cyclic AMP levels in normal versus norepinephrine-depleted rat hippocampal slices. Brain Res 358: 343–348.

    Article  PubMed  CAS  Google Scholar 

  • Stell BM, Brickley SG, Tang CY, Farrant M, Mody I (2003) Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc Natl Acad Sci U S A 100: 14439–14444.

    Article  PubMed  CAS  Google Scholar 

  • Stell BM, Mody I (2002) Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. J Neurosci 22: RC223.

    PubMed  Google Scholar 

  • Straube T, Korz V, Balschun D, Frey JU (2003) Requirement of beta-adrenergic receptor activation and protein synthesis for LTP-reinforcement by novelty in rat dentate gyrus. J Physiol 552: 953–960.

    Article  PubMed  CAS  Google Scholar 

  • Weiss T, Veh RW, Heinemann U (2003) Dopamine depresses cholinergic oscillatory network activity in rat hippocampus. Eur J Neurosci 18: 2573–2580.

    Article  PubMed  Google Scholar 

  • Wilson MA, McNaughton BL (1994) Reactivation of hippocampal ensemble memories during sleep. Science 265: 676–679.

    PubMed  CAS  Google Scholar 

  • Witter MP, Groenewegen HJ, Da Silva FHL, Lohman AHM (1989) Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region. Prog Neurobiol 33: 161–253.

    Article  PubMed  CAS  Google Scholar 

  • Zola-Morgan SM, Squire LR, Amaral DG (1989) Lesions of the hippocampal formation but not lesions of the fornix or the mammillary nuclei produce long-lasting memory impairment in monkeys. J Neurosci 9: 898–913.

    PubMed  CAS  Google Scholar 

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Heinemann, U., Albrecht, D., Behr, A., von Haebler, D., Gloveli, T. (2005). Neuronal Plasticity and Seizure Spread in the Entorhinal Cortex and Hippocampus of Amygdala Kindled Rats. In: Stanton, P.K., Bramham, C., Scharfman, H.E. (eds) Synaptic Plasticity and Transsynaptic Signaling. Springer, Boston, MA. https://doi.org/10.1007/0-387-25443-9_5

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