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Leptomeningeal Metastases pp 31–52Cite as

Leptomeningeal Metastases from Solid Tumors (Meningeal Carcinomatosis)

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 125))

Abstract

Leptomeningeal metastases (LM) are increasingly recognized as a devastating complication of solid tumors. Improved treatment of primary malignancy and advances in diagnostic imaging have led to an apparent increase in the number of patients diagnosed with LM. Unfortunately, therapeutic options remain limited. Radiotherapy is used to treat bulky tumor and provide symptomatic relief. Intrathecal chemotherapy benefits a selected subset of patients. The challenge to the future is to delineate the molecular mechanisms underlying LM and to develop novel therapeutic or prophylactic modalities to combat LM.

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Authors and Affiliations

  1. Northwestern University, 710 North Lake Shore Drive, Chicago, Ill.

    Michiko Kimura Bruno M.D. & Jeffrey Raizer M.D.

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  1. Michiko Kimura Bruno M.D.
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  2. Jeffrey Raizer M.D.
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Editors and Affiliations

  1. Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021

    Lauren E. Abrey M.D.

  2. Department of Neurology, University of Southern California, Norris Comprehensive Cancer Center and Hospital, Los Angeles, CA, 90033

    Marc C. Chamberlain M.D.

  3. Departments of Neurosurgery, Bioengineering & Molecular Genetics, University of Illinois at Chicago, Chicago, IL, 60612

    Herbert H. Engelhard M.D., PhD.

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Bruno, M.K., Raizer, J. (2005). Leptomeningeal Metastases from Solid Tumors (Meningeal Carcinomatosis). In: Abrey, L.E., Chamberlain, M.C., Engelhard, H.H. (eds) Leptomeningeal Metastases. Cancer Treatment and Research, vol 125. Springer, Boston, MA. https://doi.org/10.1007/0-387-24199-X_3

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