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Somatostatin and Opioid Receptors in Mammary Tissue

Role in cancer cell growth

  • Chapter
Biology of the Mammary Gland

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 480))

Abstract

Somatostatin and opioid systems, are the two main inhibitory systems in mammals. Both classes of substances have been identified in normal and malignant mammary gland, as well as their cognitive receptors. They have been implied in the inhibition of cell growth of cancer cells and cell lines, in a dose-dependant and reversible manner. Somatostatin acts through homologous receptors (SSTRs), belonging to five distinct classes (SSTR1-5). We, and others have identified SSTR2 and 3 as been the only SSTRs present in the breast. Furthermore, opioids act through the three classes of opioid receptors (μ,δ,κ).Inthe breast,kappa opioid receptor subtypes(κ1-κ3) are the most widely expressed. We further have shown that opioids, in additionto their binding to opioid receptors, compete for binding to SSTRs. This functional interaction, together with other identified modes of opioid action in the breast (modulation ofsteroid receptors,proteases,secretion,interaction with cytoskeletalelements),will be discussed,takingintoconsiderationalso the possible local production of casomorphins (casein-derived opioids), which are very potent antiproliferative agents.

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Author information

Authors and Affiliations

  1. Lab. of Experimental Endocrinology, School of Medicine, Heraklion

    Anastassia Hatzoglou, Efstathia Bakogeorgou, Marillena Kampa & Elias Castanas

  2. Experimental Cancerology, School of Medicine, Marseille, France

    Simone Panagiotou & Pierre-Marie Martin

  3. Institute of Biology, NCSR Democritos, Athens, Greece

    Spyros Loukas

Authors
  1. Anastassia Hatzoglou
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  2. Efstathia Bakogeorgou
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  3. Marillena Kampa
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  4. Simone Panagiotou
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  5. Pierre-Marie Martin
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  6. Spyros Loukas
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  7. Elias Castanas
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Editors and Affiliations

  1. Utrecht University, Utrecht, The Netherlands

    Jan A. Mol

  2. Hannah Research Institute, Ayr, Scotland, UK

    Roger A. Clegg

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© 2002 Kluwer Academic Publishers

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Hatzoglou, A. et al. (2002). Somatostatin and Opioid Receptors in Mammary Tissue. In: Mol, J.A., Clegg, R.A. (eds) Biology of the Mammary Gland. Advances in Experimental Medicine and Biology, vol 480. Springer, Boston, MA. https://doi.org/10.1007/0-306-46832-8_6

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  • DOI: https://doi.org/10.1007/0-306-46832-8_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46414-0

  • Online ISBN: 978-0-306-46832-2

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