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Desmoplastic Fibroma of the Mandible: A Series of Three Cases and Review of Literature

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Abstract

The desmoplastic fibroma (DF) is a rare, fibroblastic lesion of bone that histologically resembles the desmoid tumor of soft tissue. Although classified as benign, it frequently demonstrates aggressive behavior, often causing tooth mobility, extensive bone destruction, and has a moderate to high recurrence rate. We present three cases of DF in the mandible: the first in a 13 year old female involving the mandibular body in the region of teeth #s 27–#28, the second in a 57 year old female with a lesion apical to tooth #30, and the third in a 20-year-old female involving the left posterior mandible. Clinical, histologic, immunohistochemical (IHC) and radiographic features of this rare neoplasm are discussed. The challenges encountered in establishing an accurate diagnosis due to significant microscopic overlap with other spindle cell lesions are also detailed. Additionally, the findings of IHC stains including vimentin, smooth muscle actin, S-100 protein, β-catenin, HHF-35 and proliferation marker, Ki-67 on 3 cases are reported. The potential for misdiagnosis is high, especially in early lesions, since immunohistochemistry has been reported in literature to be inconsistent when differentiating DFs from other spindle cell lesions. A comparative review of DF and similar entities in the jaws with current considerations in treatment and prognosis is presented.

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Acknowledgments

We would like to thank Dr. Barton Blumberg of The Villages, Florida for his contribution to Case 2.

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Authors and Affiliations

  1. Division of Oral and Maxillofacial Pathology, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, PO Box 100414, JHMHC, Gainesville, FL, 32610-0414, USA

    T. R. Woods, D. M. Cohen, M. N. Islam & I. Bhattacharyya

  2. Department of Oral and Maxillofacial Pathology, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, USA

    Y. Rawal

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  1. T. R. Woods
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  2. D. M. Cohen
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  3. M. N. Islam
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Correspondence to I. Bhattacharyya.

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Woods, T.R., Cohen, D.M., Islam, M.N. et al. Desmoplastic Fibroma of the Mandible: A Series of Three Cases and Review of Literature. Head and Neck Pathol 9, 196–204 (2015). https://doi.org/10.1007/s12105-014-0561-5

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  • DOI: https://doi.org/10.1007/s12105-014-0561-5

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