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A Comprehensive Review on Mustard-Induced Allergy and Implications for Human Health

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Abstract

Mustard is widely used in a variety of foods/food products to enhance the flavor and nutritional value that subsequently raise the risk of hypersensitivity reactions. Mustard allergy has been reported for many years and is increasing gradually especially in the areas where its consumption is comparatively higher, and it may be considered among the most important food allergies. A number of relevant clinical studies focused on mustard-induced allergic manifestations are summarized in the current review. In addition, the knowledge regarding the immunological as well as biochemical characteristics of mustard allergens that have been known till date and their cross-reactivity with other food allergens have also been discussed here. Notably, mustard may also be present as a hidden allergen in foods; therefore, it is important to recognize food products that may contain mustard as it may pose potential risk for the allergic individuals. Additionally, the better understanding of the underlying mechanism in mustard allergy is a prerequisite for the development of specific therapeutic procedures. Conclusively, mustard sensitivity should be routinely tested in patients with idiopathic anaphylaxis for the safety of the allergic patients.

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Abbreviations

APC:

Antigen-presenting cells

SPT:

Skin prick test

DBPCFC:

Double-blind placebo-controlled food challenge

PFAS:

Pollen-food allergy syndrome

LA:

Latex allergy

NRL:

Natural rubber latex

mAbs:

Monoclonal antibodies

LTPs:

Lipid transfer proteins

MW:

Molecular weight

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Acknowledgements

The authors wish to thank Professor Alok Dhawan, Director, CSIR-IITR for his encouragement and support. Financial support from CSIR Research Grant InDepth (BSC-0111) is acknowledged. Dr. Akanksha Sharma is grateful to the Council of Scientific and Industrial Research, New Delhi, for the award of her Senior Research Fellowship. She conveys her gratitude to the Academy of Scientific and Innovative Research (AcSIR), New Delhi. Mr. Rinkesh Kumar Gupta and Neelabh are thankful to the Indian Council of Medical Research (ICMR), New Delhi, for the award of their Senior Research Fellowship. This is CSIR-IITR manuscript no-3481.

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Authors and Affiliations

  1. Food Toxicology Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 31, Vishvigyan Bhawan, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226 001, India

    Akanksha Sharma, Rinkesh Kumar Gupta & Premendra D. Dwivedi

  2. Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center, Tulane University School of Medicine, New Orleans, LA, 70112,, USA

    Alok K. Verma

  3. Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR, Lucknow, India

    Akanksha Sharma & Premendra D. Dwivedi

  4. Department of Zoology, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, 221005,, India

    Neelabh

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  1. Akanksha Sharma
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  2. Alok K. Verma
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  3. Rinkesh Kumar Gupta
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  4. Neelabh
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  5. Premendra D. Dwivedi
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Correspondence to Premendra D. Dwivedi.

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Sharma, A., Verma, A.K., Gupta, R.K. et al. A Comprehensive Review on Mustard-Induced Allergy and Implications for Human Health. Clinic Rev Allerg Immunol 57, 39–54 (2019). https://doi.org/10.1007/s12016-017-8651-2

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