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Neurogenic Claudication: a Review of Current Understanding and Treatment Options

  • Neuropathic Pain (A Abd-Elsayed, Section Editor)
  • Published:
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Abstract

Purpose of Review

With an aging population and increased prevalence of the disease, we set out to evaluate the validity of current diagnostic criteria for neurogenic claudication as well as the efficacy of the treatment options for the main cause, lumbar spinal stenosis (LSS).

Recent Findings

Epidural steroid injections (ESI) were most efficacious when the injectate is a steroid combined with lidocaine or lidocaine only. There are promising results regarding the efficacy of the minimally invasive lumbar decompression (MILD) procedure as well as interspinous process spacers (IPS) compared to surgical alternatives. Spinal cord stimulators are gaining ground as an effective alternative to surgery in patients with lumbar spinal stenosis that is not responsive to conservative measures or epidural injections.

Summary

We found that there continues to be a lack of consensus on the diagnostic criteria, management, and treatment options for patients with LSS. The Delphi consensus is the most current recommendation to assist clinicians with making the diagnosis. Physical therapy, NSAIDs, gabapentin, and other conservative therapy measures are unproven in providing long-lasting relief. In patients with radicular symptoms, an ESI may be indicated when a combination of lidocaine with steroids is used or using lidocaine alone. In addition, there is not enough high-quality evidence to make a recommendation regarding the use of MILD versus interspinous spacers for neurogenic claudication. There remains a need for high-quality evidence regarding the efficacy of different conservative treatments, interventional procedures, and surgical outcomes in patients with neurogenic claudication in LSS.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Hall S, Bartleson JD, Onofrio BM, Baker HL Jr, Okazaki H, O’Duffy JD. Lumbar spinal stenosis. Clinical features, diagnostic procedures, and results of surgical treatment in 68 patients. Ann Intern Med. 1985;103(2):271–5.

    Article  CAS  PubMed  Google Scholar 

  2. Malgor RD, Alahdab F, Elraiyah TA, Rizvi AZ, Lane MA, Prokop LJ, et al. A systematic review of treatment of intermittent claudication in the lower extremities. J Vasc Surg. 2015;61(3 Suppl):54S–73S.

    Article  PubMed  Google Scholar 

  3. Leriche R, Morel A. The syndrome of thrombotic obliteration of the aortic bifurcation. Ann Surg. 1948;127(2):193–206.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Frederick M, Newman J, Kohlwes J. Leriche syndrome. J Gen Intern Med. 2010;25(10):1102–4.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Conte SM, Vale PR. Peripheral arterial disease. Heart Lung Circ. 2018;27(4):427–32.

    Article  PubMed  Google Scholar 

  6. Mascarenhas JV, Albayati MA, Shearman CP, Jude EB. Peripheral arterial disease. Endocrinol Metab Clin N Am. 2014;43(1):149–66.

    Article  Google Scholar 

  7. Van der Velden SK, Shadid NH, Nelemans PJ, Sommer A. How specific are venous symptoms for diagnosis of chronic venous disease? Phlebology. 2014;29(9):580–6.

    Article  PubMed  Google Scholar 

  8. Porter RW. Spinal stenosis and neurogenic claudication. Spine (Phila Pa 1976). 1996;21(17):2046–52.

    Article  CAS  Google Scholar 

  9. Melancia JL, Francisco AF, Antunes JL. Spinal stenosis. Handb Clin Neurol. 2014;119:541–9.

    Article  PubMed  Google Scholar 

  10. Truumees E. Spinal stenosis: pathophysiology, clinical and radiologic classification. Instr Course Lect. 2005;54:287–302.

    PubMed  Google Scholar 

  11. Foris LA, Varacallo M. Spinal stenosis and neurogenic claudication. Treasure Island (FL): StatPearls; 2018.

    Google Scholar 

  12. Kalichman L, Cole R, Kim DH, Li L, Suri P, Guermazi A, et al. Spinal stenosis prevalence and association with symptoms: the Framingham Study. Spine J. 2009;9(7):545–50.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Deyo RA, Gray DT, Kreuter W, Mirza S, Martin BI. United States trends in lumbar fusion surgery for degenerative conditions. Spine (Phila Pa 1976). 2005;30(12):1441–5 discussion 6-7.

    Article  Google Scholar 

  14. Inufusa A, An HS, Lim TH, Hasegawa T, Haughton VM, Nowicki BH. Anatomic changes of the spinal canal and intervertebral foramen associated with flexion-extension movement. Spine (Phila Pa 1976). 1996;21(21):2412–20.

    Article  CAS  Google Scholar 

  15. Sekiguchi M, Kikuchi S. Experimental studies of lumbar spinal stenosis. Clin Calcium. 2005;15(3):51–6.

    PubMed  Google Scholar 

  16. Katz JN, Dalgas M, Stucki G, Katz NP, Bayley J, Fossel AH, et al. Degenerative lumbar spinal stenosis. Diagnostic value of the history and physical examination. Arthritis Rheum. 1995;38(9):1236–41.

    Article  CAS  Google Scholar 

  17. Binder DK, Schmidt MH, Weinstein PR. Lumbar spinal stenosis. Semin Neurol. 2002;22(2):157–66.

    Article  PubMed  Google Scholar 

  18. Giugliani R, Harmatz P, Wraith JE. Management guidelines for mucopolysaccharidosis VI. Pediatrics. 2007;120(2):405–18.

    Article  PubMed  Google Scholar 

  19. Wraith JE, Scarpa M, Beck M, Bodamer OA, De Meirleir L, Guffon N, et al. Mucopolysaccharidosis type II (Hunter syndrome): a clinical review and recommendations for treatment in the era of enzyme replacement therapy. Eur J Pediatr. 2008;167(3):267–77.

    Article  CAS  PubMed  Google Scholar 

  20. Semenza GL, Pyeritz RE. Respiratory complications of mucopolysaccharide storage disorders. Medicine (Baltimore). 1988;67(4):209–19.

    Article  CAS  Google Scholar 

  21. Westcott MA, Dynes MC, Remer EM, Donaldson JS, Dias LS. Congenital and acquired orthopedic abnormalities in patients with myelomeningocele. Radiographics. 1992;12(6):1155–73.

    Article  CAS  PubMed  Google Scholar 

  22. Verbiest H. A radicular syndrome from developmental narrowing of the lumbar vertebral canal. J Bone Joint Surg Br. 1954;36-B(2):230–7.

    Article  CAS  PubMed  Google Scholar 

  23. Maus TP. Imaging of spinal stenosis: neurogenic intermittent claudication and cervical spondylotic myelopathy. Radiol Clin N Am. 2012;50(4):651–79.

    Article  PubMed  Google Scholar 

  24. •• Tomkins-Lane C, Melloh M, Lurie J, Smuck M, Battie MC, Freeman B, et al. ISSLS prize winner: consensus on the clinical diagnosis of lumbar spinal stenosis: results of an international Delphi study. Spine (Phila Pa 1976). 2016;41(15):1239–46. A Delphi study that formulated a consensus on 7 questions to serve as a guide in the diagnostic process of patients with LSS.

    Article  Google Scholar 

  25. Tran DQ, Duong S, Finlayson RJ. Lumbar spinal stenosis: a brief review of the nonsurgical management. Can J Anaesth. 2010;57(7):694–703.

    Article  PubMed  Google Scholar 

  26. Eskola A, Pohjolainen T, Alaranta H, Soini J, Tallroth K, Slatis P. Calcitonin treatment in lumbar spinal stenosis: a randomized, placebo-controlled, double-blind, cross-over study with one-year follow-up. Calcif Tissue Int. 1992;50(5):400–3.

    Article  CAS  PubMed  Google Scholar 

  27. Podichetty VK, Segal AM, Lieber M, Mazanec DJ. Effectiveness of salmon calcitonin nasal spray in the treatment of lumbar canal stenosis: a double-blind, randomized, placebo-controlled, parallel group trial. Spine (Phila Pa 1976). 2004;29(21):2343–9.

    Article  Google Scholar 

  28. Tafazal SI, Ng L, Sell P. Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. Eur Spine J. 2007;16(2):207–12.

    Article  PubMed  Google Scholar 

  29. Podichetty VK, Varley ES, Lieberman I. Calcitonin treatment in lumbar spinal stenosis: a meta-analysis. Spine (Phila Pa 1976). 2011;36(5):E357–64.

    Article  Google Scholar 

  30. Ammendolia C, Stuber KJ, Rok E, Rampersaud R, Kennedy CA, Pennick V, et al. Nonoperative treatment for lumbar spinal stenosis with neurogenic claudication. Cochrane Database Syst Rev. 2013;8:CD010712.

    Google Scholar 

  31. Matsudaira K, Seichi A, Kunogi J, Yamazaki T, Kobayashi A, Anamizu Y, et al. The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis. Spine (Phila Pa 1976). 2009;34(2):115–20.

    Article  PubMed  Google Scholar 

  32. Yaksi A, Ozgonenel L, Ozgonenel B. The efficiency of gabapentin therapy in patients with lumbar spinal stenosis. Spine (Phila Pa 1976). 2007;32(9):939–42.

    Article  Google Scholar 

  33. Waikakul W, Waikakul S. Methylcobalamin as an adjuvant medication in conservative treatment of lumbar spinal stenosis. J Med Assoc Thail. 2000;83(8):825–31.

    CAS  Google Scholar 

  34. Goren A, Yildiz N, Topuz O, Findikoglu G, Ardic F. Efficacy of exercise and ultrasound in patients with lumbar spinal stenosis: a prospective randomized controlled trial. Clin Rehabil. 2010;24(7):623–31.

    Article  PubMed  Google Scholar 

  35. Pua YH, Cai CC, Lim KC. Treadmill walking with body weight support is no more effective than cycling when added to an exercise program for lumbar spinal stenosis: a randomised controlled trial. Aust J Physiother. 2007;53(2):83–9.

    Article  PubMed  Google Scholar 

  36. Koc Z, Ozcakir S, Sivrioglu K, Gurbet A, Kucukoglu S. Effectiveness of physical therapy and epidural steroid injections in lumbar spinal stenosis. Spine (Phila Pa 1976). 2009;34(10):985–9.

    Article  Google Scholar 

  37. Whitman JM, Flynn TW, Childs JD, Wainner RS, Gill HE, Ryder MG, et al. A comparison between two physical therapy treatment programs for patients with lumbar spinal stenosis: a randomized clinical trial. Spine (Phila Pa 1976). 2006;31(22):2541–9.

    Article  PubMed  Google Scholar 

  38. Iannuccilli JD, Prince EA, Soares GM. Interventional spine procedures for management of chronic low back pain-a primer. Semin Intervent Radiol. 2013;30(3):307–17.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Manchikanti L, Cash KA, McManus CD, Pampati V, Fellows B. Results of 2-year follow-up of a randomized, double-blind, controlled trial of fluoroscopic caudal epidural injections in central spinal stenosis. Pain Physician. 2012;15(5):371–84.

    PubMed  Google Scholar 

  40. Manchikanti L, Singh V, Cash KA, Pampati V, Damron KS, Boswell MV. A randomized, controlled, double-blind trial of fluoroscopic caudal epidural injections in the treatment of lumbar disc herniation and radiculitis. Spine (Phila Pa 1976). 2011;36(23):1897–905.

    Article  Google Scholar 

  41. Manchikanti L, Cash KA, McManus CD, Pampati V, Singh V, Benyamin R. The preliminary results of a comparative effectiveness evaluation of adhesiolysis and caudal epidural injections in managing chronic low back pain secondary to spinal stenosis: a randomized, equivalence controlled trial. Pain Physician. 2009;12(6):E341–54.

    PubMed  Google Scholar 

  42. • Manchikanti L, Knezevic NN, Boswell MV, Kaye AD, Hirsch JA. Epidural injections for lumbar radiculopathy and spinal stenosis: a comparative systematic review and meta-analysis. Pain Physician. 2016;19(3):E365–410. A large meta-analysis that found bupivicaine to be ineffective in ESI and lidocaine alone was as effective as lidocaine with steroids.

  43. Benyamin RM, Staats PS, MiDAS ENCORE. Randomized controlled study design and protocol. Pain Physician. 2015;18(4):307–16.

    PubMed  Google Scholar 

  44. Benyamin RM, Staats PS, Mi DASEI. MILD(R) is an effective treatment for lumbar spinal stenosis with neurogenic claudication: MiDAS ENCORE randomized controlled trial. Pain Physician. 2016;19(4):229–42.

    PubMed  Google Scholar 

  45. •• Staats PS, Chafin TB, Golovac S, Kim CK, Li S, Richardson WB, et al. Long-term safety and efficacy of minimally invasive lumbar decompression procedure for the treatment of lumbar spinal stenosis with neurogenic claudication: 2-year results of MiDAS ENCORE. Reg Anesth Pain Med. 2018;43(7):789–94. The first long-term data from a RCT to demonstrate the efficacy of the MILD procedure when compared to ESI.

  46. Elsheikh NA, Amr YM. Effect of adding calcitonin to translaminar epidural steroid in degenerative lumbar Spinal canal stenosis. Pain Physician. 2016;19(3):139–46.

    PubMed  Google Scholar 

  47. Malmivaara A, Slatis P, Heliovaara M, Sainio P, Kinnunen H, Kankare J, et al. Surgical or nonoperative treatment for lumbar spinal stenosis? A randomized controlled trial. Spine (Phila Pa 1976). 2007;32(1):1–8.

    Article  Google Scholar 

  48. Patel VV, Whang PG, Haley TR, Bradley WD, Nunley PD, Davis RP, et al. Superion interspinous process spacer for intermittent neurogenic claudication secondary to moderate lumbar spinal stenosis: two-year results from a randomized controlled FDA-IDE pivotal trial. Spine (Phila Pa 1976). 2015;40(5):275–82.

    Article  PubMed  Google Scholar 

  49. Schizas C, Pralong E, Tzioupis C, Kulik G. Interspinous distraction in lumbar spinal stenosis: a neurophysiological perspective. Spine (Phila Pa 1976). 2013;38(24):2113–7.

    Article  Google Scholar 

  50. Stromqvist BH, Berg S, Gerdhem P, Johnsson R, Moller A, Sahlstrand T, et al. X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up. Spine (Phila Pa 1976). 2013;38(17):1436–42.

    Article  Google Scholar 

  51. • Gala RJ, Russo GS, Whang PG. Interspinous implants to treat spinal stenosis. Curr Rev Musculoskelet Med. 2017;10(2):182–8. Compared Superion with X-Stop and found Superion to have improved outcomes at 3-year follow-up.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Ravindra VM, Ghogawala Z. Is there still a role for interspinous spacers in the management of neurogenic claudication? Neurosurg Clin N Am. 2017;28(3):321–30.

    Article  PubMed  Google Scholar 

  53. Costantini A, Buchser E, Van Buyten JP. Spinal cord stimulation for the treatment of chronic pain in patients with lumbar spinal stenosis. Neuromodulation. 2010;13(4):275–9 discussion 9-80.

    Article  PubMed  Google Scholar 

  54. Kamihara M, Nakano S, Fukunaga T, Ikeda K, Tsunetoh T, Tanada D, et al. Spinal cord stimulation for treatment of leg pain associated with lumbar spinal stenosis. Neuromodulation. 2014;17(4):340–4 discussion 5.

    Article  Google Scholar 

  55. • Zaina F, Tomkins-Lane C, Carragee E, Negrini S. Surgical versus nonsurgical treatment for lumbar spinal stenosis. Spine (Phila Pa 1976). 2016;41(14):E857–68. A large Cochrane review that evaluated the available evidence from 5 RCTs regarding surgical vs non surgical treatment of LSS. They were not able to prove superiority of either treatment.

    Article  PubMed  Google Scholar 

  56. • Forsth P, Olafsson G, Carlsson T, Frost A, Borgstrom F, Fritzell P, et al. A randomized, controlled trial of fusion surgery for lumbar spinal stenosis. N Engl J Med. 2016;374(15):1413–23. A large RCT that compared surgical decompression with decompression plus fusion. They showed that fusion increases operative time and risk with no added improvement in ODI scores and similar reoperation rates when compared to decompression alone.

    Article  PubMed  CAS  Google Scholar 

  57. • Tye EY, Anderson JT, Haas AR, Percy R, Woods ST, Ahn UM, et al. Decompression versus decompression and fusion for degenerative lumbar stenosis in a workers’ compensation setting. Spine (Phila Pa 1976). 2017;42(13):1017–23. A retrospective cohort study that compared surgical decompression with decompression plus fusion in worker's comp cases and showed a higher return to work rates in the decompression only group.

    Article  PubMed  Google Scholar 

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Correspondence to Nebojsa Nick Knezevic.

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Shadi Messiah, Antony R. Tharian, Kenneth D. Candido, and Nebojsa Nick Knezevic declare that they have no conflict of interest.

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Messiah, S., Tharian, A.R., Candido, K.D. et al. Neurogenic Claudication: a Review of Current Understanding and Treatment Options. Curr Pain Headache Rep 23, 32 (2019). https://doi.org/10.1007/s11916-019-0769-x

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