Abstract
While the national HIV infection rate is decreasing, the highest rates of infections continue among men who have sex with men (MSM), particularly minority MSM. It is important to understand attitudes, knowledge, and behaviors surrounding HIV prevention methods, such as pre-exposure prophylaxis (PrEP). In the present study, we created a snapshot of the PrEP continuum of care and identified participant demographic and sources of PrEP awareness factors that were associated with PrEP initiation. Data were collected using anonymous paper–based surveys employing a venue intercept procedure. A total of 188 HIV–negative men completed the survey at Miami Gay Pride 2018. Participants answered questions regarding demographics, PrEP use, and sources of PrEP awareness. The sample was majority Hispanic (55.4%), gay (83.0%), and single (57.7%). The constructed PrEP continuum revealed that a low proportion of those identified as PrEP naïve (n = 143) for HIV infection had PrEP interest (49/143). Moreover, among those who initiated PrEP (n = 45), a high proportion were retained in a PrEP program (37/45), with approximately half achieving medication adherence (25/45). Age group, PrEP knowledge, and source of PrEP awareness were all significantly associated with PrEP initiation. In areas with high HIV infection rates, studies like these offer crucial insight on how public health practitioners should proceed in the goal of decreasing HIV transmission rates. More research is needed to increase PrEP uptake and adherence.
Similar content being viewed by others
References
Centers for Disease Control and Prevention. HIV surveillance report, 2017. 2018; 29; Retrieved From: http://www.cdc.gov/hiv/library/reports/hiv-surveillance.html. Accessed 15 Jan 2019.
Florida Department of Health. Epidemiologic profile report. 2018; Retrieved From: http://www.floridahealth.gov/diseases-and-conditions/aids/surveillance/epi-profiles/index.html. Accessed 30 Apr 2019.
Food and Drug Administration (FDA). FDA approves first drug for reducing the risk of sexually acquired HIV infection. 2012; Retrieved From: https://wayback.archive-it.org/7993/20170112032741/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm312210.htm. Accessed 15 Sept 2018.
Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587–99.
McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2016;387(10013):53–60.
Mantell JE, Sandfort TG, Hoffman S, et al. Knowledge and attitudes about preexposure prophylaxis (PrEP) among sexually active men who have sex with men and who participate in New York city gay pride events. LGBT Health. 2014;1(2):93–7.(https://home.liebertpub.com/publications/lgbt-health/618/overview)
AIDSVu. Tools & Resources: Datasets. Retrieved From: https://aidsvu.org/resources/#/. Accessed 30 Apr 2019.
Centers for Disease Control and Prevention. HIV prevention pill not reaching most Americans who could benefit – especially people of color. NCHHSTP Newsroom 2018; Retrieved From: https://www.cdc.gov/nchhstp/newsroom/2018/croi-2018-PrEP-press-release.html. Accessed 15 Sept 2018.
Sullivan PS, Carballo-Diéguez A, Coates T, Goodreau SM, McGowan I, Sanders EJ, et al. Successes and challenges of HIV prevention in men who have sex with men. Lancet. 2012;380(9839):388–99.
Liu A, Colfax G, Cohen S, et al. The spectrum of engagement in HIV prevention: proposal for a PrEP cascade. 2012; Retrieve From: http://iapac.org/AdherenceConference/presentations/ADH7_80040.pdf. Accessed 15 Sept 2018.
Kelley CF, Kahle E, Siegler A, Sanchez T, del Rio C, Sullivan PS, et al. Applying a PrEP continuum of care for men who have sex with men in Atlanta, Georgia. Clin Infect Dis. 2015;61(10):1590–7.
Nunn AS, Brinkley-Rubinstein L, Oldenburg CE, Mayer KH, Mimiaga M, Patel R, et al. Defining the HIV pre-exposure prophylaxis care continuum. AIDS. 2017;31(5):731–4.
Parsons JT, Rendina HJ, Lassiter JM, Whitfield THF, Starks TJ, Grov C. Uptake of HIV pre-exposure prophylaxis (PrEP) in a national cohort of gay and bisexual men in the United States. Journal of Acquired Immune Deficiency Syndrome. 2017;74(3):285–92. https://journals.lww.com/jaids/pages/default.aspx.
Hood JE, Buskin SE, Dombrowski JC, Kern DA, Barash EA, Katz DA, et al. Dramatic increase in preexposure prophylaxis use among MSM in Washington state. AIDS. 2016;30(3):515–9.
Bauermeister JA, Meanley S, Pingel E, Soler JH, Harper GW. PrEP awareness and perceived barriers among single young men who have sex with men in the United States. Curr HIV Res. 2013;11(7):520.
Dolezal C, Frasca T, Giguere R, Ibitoye M, Cranston RD, Febo I, et al. Awareness of post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP) is low but interest is high among men engaging in condomless anal sex with men in Boston, Pittsburgh, and San Juan. AIDS Educ Prev. 2015;27(4):289–97.
Snowden JM, Chen Y, McFarland W, et al. Prevalence and characteristics of users of pre-exposure prophylaxis (PrEP) among men who have sex with men, San Francisco, 2014 in a cross-sectional survey: implications for disparities. Sex Transm Infect. 2017;93(1):52–5.
Cohen SE, Vittinghoff E, Bacon O, Doblecki-Lewis S, Postle BS, Feaster DJ, et al. High interest in pre-exposure prophylaxis among men who have sex with men at risk for HIV-infection: baseline data from the US PrEP demonstration project. J Acquir Immune Defic Syndr. 2015;68(4):439–48.
Landovitz RJ, Tseng C, Weissman M, et al. Epidemiology, sexual risk behavior, and HIV prevention practices of men who have sex with men using GRINDR in Los Angeles, California. J Urban Health. 2013;90(4):729–39.
Mayer KH, Oldenburg CE, Novak DS, Elsesser SA, Krakower DS, Mimiaga MJ. Early adopters: correlates of HIV chemoprophylaxis use in recent online samples of US men who have sex with men. AIDS Behav. 2016;20(7):1489–98.
Holloway IW, Dougherty R, Gildner J, Beougher SC, Pulsipher C, Montoya JA, et al. Brief report: PrEP uptake, adherence, and discontinuation among California YMSM using geosocial networking applications. J Acquir Immune Defic Syndr. 2017;74(1):15–20.
Grant RM, Anderson PL, McMahan V, Liu A, Amico KR, Mehrotra M, et al. Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis. 2014;14(9):820–9.
Krakower DS, Mimiaga MJ, Rosenberger JG, Novak DS, Mitty JA, White JM, et al. Limited awareness and low immediate uptake of pre-exposure prophylaxis. PLoS One. 2012;7(3):e33119.
Golub SA, Gamarel KE, Rendina HJ, Surace A, Lelutiu-Weinberger CL. From efficacy to effectiveness: facilitators and barriers to PrEP acceptability and motivations for adherence among MSM and transgender women in New York city. AIDS Patient Care STDs. 2013;27(4):248–54.
Pérez-Figueroa RE, Kapadia F, Barton SC, Eddy JA, Halkitis PN. Acceptability of PrEP uptake among racially/ethnically diverse young men who have sex with men: the P18 study. AIDS Educ Prev. 2015;27(2):112–25.
Eaton LA, Kalichman SC, Price D, Finneran S, Allen A, Maksut J. Stigma and conspiracy beliefs related to pre-exposure prophylaxis (PrEP) and interest in using PrEP among Black and White men and transgender women who have sex with men. AIDS Behav. 2017;21(5):1236–46.
Crawford JM, Rodden P, Kippax S, van de Ven P. Negotiated safety and other agreements between men in relationships: risk practice redefined. Int J STD AIDS. 2001;12(3):164–70.
Hoff CC, Beougher SC, Chakravarty D, Darbes LA, Neilands TB. Relationship characteristics and motivations behind agreements among gay male couples: differences by agreement type and couple serostatus. AIDS Care. 2010;22(7):827–35.
Mitchell JW, Harvey SM, Champeau D, Seal DW. Relationship factors associated with HIV risk among a sample of gay male couples. AIDS Behav. 2012;16(2):404–11.
National Institute on Alcohol Abuse and Alcoholism (NIAAA). Recommended alcohol questions. 2003; Retreived From: https://www.niaaa.nih.gov/research/guidelines-and-resources/recommended-alcohol-questions. Accessed 15 Sept 2018.
Chan PA, Mena L, Patel R, Oldenburg CE, Beauchamps L, Perez-Brumer AG, Parker S, Mayer KH, Mimiaga MJ, Nunn A Retention in care outcomes for HIV pre-exposure prophylaxis implementation programmes among men who have sex with men in three US cities. J Int AIDS Soc 2016; 19(1)
Fenway Institute. Building patient-centered medical homes for lesbian, gay, bisexual, and transgender patients and families. 2016; Retrieved From: https://www.lgbthealtheducation.org/wp-content/uploads/Building-PCMH-for-LGBT-Patients-and-Families.pdf. Accessed 15 Jan 2019.
Landry J. Delivering culturally sensitive care to LGBTQI patients. J Nurse Pract. 2017;13(5):342–7.
Liu A, Cohen S, Follansbee S, Cohan D, Weber S, Sachdev D, et al. Early experiences implementing pre-exposure prophylaxis (PrEP) for HIV prevention in San Francisco. PLoS Med. 2014;11(3):e1001613.
Saberi P, Berrean B, Thomas S, Gandhi M, Scott H. A simple pre-exposure prophylaxis (PrEP) optimization intervention for health care providers prescribing PrEP: pilot study. JMIR Formative Research. 2018;2(1):e2.https://formative.jmir.org/
Acknowledgements
We would like to thank Isis Monzon for her assistance in the data collection of this study. We would also like to acknowledge the National Institute on Drug Abuse, grant number 1R01DA042069-01A1 (PI:Cook) for funding this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
This study was approved by the Florida International University Institutional Review Board.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Algarin, A.B., Shrader, C.H., Bhatt, C. et al. The Pre-exposure Prophylaxis (PrEP) Continuum of Care and Correlates to Initiation Among HIV-Negative Men Recruited at Miami Gay Pride 2018. J Urban Health 96, 835–844 (2019). https://doi.org/10.1007/s11524-019-00362-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11524-019-00362-4