Abstract
Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. Our results indicated that eurycomanone did not potently inhibit any of the CYP isoforms investigated, with IC50 values greater than 250 μg/ml. Hence there appears to be little likelihood of drug–herb interaction between eurycomanone or herbal products with high content of this compound and CYP drug substrates via CYP inhibition.
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Acknowledgments
The authors thank the Malaysian Ministry of Science, Technology and Innovation (Grant: eScienceFund 02-02-09-SF0005) for kind funding and support given to this study.
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Pan, Y., Tiong, K.H., Abd-Rashid, B.A. et al. Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro. J Nat Med 68, 402–406 (2014). https://doi.org/10.1007/s11418-013-0794-8
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DOI: https://doi.org/10.1007/s11418-013-0794-8