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Three new megastigmanes from the leaves of Annona muricata

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Abstract

Three new megastigmanes (1–3), named annoionols A and B (1, 2) and annoionoside (3), were isolated from the leaves of Annona muricata L. (Annonaceae) together with 14 known compounds (4–17). Among the known compounds, annoionol C (4) was isolated from a natural source for the first time. The structures of all compounds were elucidated by spectroscopic and chemical analyses.

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Acknowledgments

The authors are grateful for the access to the superconducting NMR instrument (JEOL ECA-600) and the Applied Biosystem QSTAR XL system ESI (NanoSpray) mass spectrometer at the Natural Science Center for Basic Research and Development (N-BARD), Hiroshima University. This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Nos. 22590006 and 23590130), and the Ministry of Health, Labour and Welfare. Thanks are also due to the Research Foundation for Pharmaceutical Sciences and the Takeda Science Foundation for their financial support.

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Authors and Affiliations

  1. Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Ayano Matsushige, Yaichiro Kotake & Shigeru Ohta

  2. Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Katsuyoshi Matsunami & Hideaki Otsuka

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  1. Ayano Matsushige
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  2. Katsuyoshi Matsunami
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  3. Yaichiro Kotake
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  4. Hideaki Otsuka
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  5. Shigeru Ohta
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Correspondence to Hideaki Otsuka.

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Matsushige, A., Matsunami, K., Kotake, Y. et al. Three new megastigmanes from the leaves of Annona muricata . J Nat Med 66, 284–291 (2012). https://doi.org/10.1007/s11418-011-0583-1

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  • DOI: https://doi.org/10.1007/s11418-011-0583-1

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