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Extracellular creatine kinase may modulate purinergic signalling

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Abstract

Extracellular purine nucleotides and nucleosides including ADP and ATP regulate a wide array of physiological processes including platelet aggregation, vasomotor responses and inflammation through specific purinergic receptors. In the recent years, a strong association has been reported between circulating cytoplasmic-type creatine kinase and adverse clinical outcomes such as major bleeding, hypertension and obesity. Therefore, it is proposed that extracellular CK may modulate purinergic signalling through its ADP binding and/or ATP-generating effect.

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  1. CK Science Foundation, POB 23639, 1100, EC, Amsterdam, the Netherlands

    L. M. Brewster

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  1. L. M. Brewster
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Correspondence to L. M. Brewster.

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LMB is an inventor on patent WO/2012/138226, an “open” non-restrictive patent request filed and published as “prior art” to protect the freedom of researchers to operate and share their innovative ideas on CK and CK inhibition without licence or payment.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Brewster, L.M. Extracellular creatine kinase may modulate purinergic signalling. Purinergic Signalling 16, 305–312 (2020). https://doi.org/10.1007/s11302-020-09707-0

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