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A case of resistance to clopidogrel and prasugrel after percutaneous coronary angioplasty

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References

  1. Ellis KJ, Stouffer GA, McLeod HL, Lee CR (2009) Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations. Pharmacogenomics 10:1799–1817

    Article  CAS  PubMed  Google Scholar 

  2. Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, Walker JR, Antman EM, Macias W, Braunwald E, Sabatine MS (2009) Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 360:354–362

    Article  CAS  PubMed  Google Scholar 

  3. Harmsze A, van Werkum JW, Bouman HJ, Ruven HJ, Breet NJ, Ten Berg JM, Hackeng CM, Tjoeng MM, Klungel OH, de Boer A, Deneer VH (2010) Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation. Pharmacogenet Genomics 20:18–25

    Article  CAS  PubMed  Google Scholar 

  4. Lau WC, Gurbel PA, Watkins PB, Neer CJ, Hopp AS, Carville DG, Guyer KE, Tait AR, Bates ER (2004) Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation 109:166–171

    Article  CAS  PubMed  Google Scholar 

  5. Ho PM, Maddox TM, Wang L, Fihn SD, Jesse RL, Peterson ED, Rumsfeld JS (2009) Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA 301:937–944

    Article  CAS  PubMed  Google Scholar 

  6. Clarke TA, Waskell LA (2003) The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab Dispos 31:53–59

    Article  CAS  PubMed  Google Scholar 

  7. Gori AM, Marcucci R, Paniccia R, Giusti B, Fedi S, Antonucci E, Buonamici P, Antoniucci D, Gensini GF, Abbate R (2008) Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function. Thromb Haemost 100:1136–1145

    CAS  PubMed  Google Scholar 

  8. Balian JD, Sukhova N, Harris JW, Hewett J, Pickle L, Goldstein JA, Woosley RL, Flockhart DA (1995) The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study. Clin Pharmacol Ther 57:662–669

    Article  CAS  PubMed  Google Scholar 

  9. Böttiger Y (2006) Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4. Eur J Clin Pharmacol 62:621–625

    Article  PubMed  Google Scholar 

  10. Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, Walker JR, Antman EM, Macias WL, Braunwald E, Sabatine MS (2009) Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 119:2553–2560

    Article  CAS  PubMed  Google Scholar 

  11. Fontana P, Dupont A, Gandrille S, Bachelot-Loza C, Reny JL, Aiach M, Gaussem P (2003) Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation 108:989–995

    Article  CAS  PubMed  Google Scholar 

  12. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramírez C, Cavallari U, Trabetti E, Sabaté M, Jimenez-Quevedo P, Hernández R, Moreno R, Escaned J, Alfonso F, Bañuelos C, Costa MA, Bass TA, Pignatti PF, Macaya C (2005) Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 116:491–497

    Article  CAS  PubMed  Google Scholar 

  13. Eshtehardi P, Eslami M, Moayed DA (2008) Simultaneous subacute coronary drug-eluting stent thrombosis in two different vessels of a patient with factor V Leiden mutation. J Cardiovasc Med 9:410–413

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiothoracic and Vascular Sciences, University of Padova, Padova, Italy

    M. Silvano, V. Pengo & M. Napodano

  2. Department of Laboratory Medicine, University of Padova, Padova, Italy

    C. F. Zambon & M. Plebani

  3. Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy

    G. De Rosa & R. Padrini

Authors
  1. M. Silvano
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  2. C. F. Zambon
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  3. G. De Rosa
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  4. M. Plebani
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  5. V. Pengo
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  6. M. Napodano
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  7. R. Padrini
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Corresponding author

Correspondence to R. Padrini.

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Silvano, M., Zambon, C.F., De Rosa, G. et al. A case of resistance to clopidogrel and prasugrel after percutaneous coronary angioplasty. J Thromb Thrombolysis 31, 233–234 (2011). https://doi.org/10.1007/s11239-010-0533-x

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  • DOI: https://doi.org/10.1007/s11239-010-0533-x

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