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Histoplasma capsulatum Recovery from the Urine and a Short Review of Genitourinary Histoplasmosis

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Abstract

Although virtually any organ can be involved in disseminated histoplasmosis, the recovery of Histoplasma capsulatum from the urine is a rare finding. Here we describe that a renal transplant recipient had H. capsulatum recovered from urinary sediment. The organism was also recovered from urine cultures. The potential implications of this finding are discussed, and the literature on genitourinary histoplasmosis is reviewed.

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References

  1. Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev. 2007;20:115–32.

    Article  PubMed  CAS  Google Scholar 

  2. Goodwin RAJ, Shapiro JL, Thurman GH, Thurman SS, Des Prez RM. Disseminated histoplasmosis: clinical and pathologic correlations. Medicine. 1980;59:1–33.

    Article  PubMed  Google Scholar 

  3. Parsons RJ, Zarafonetis CJD. Histoplasmosis in man: reports of seven cases and a review of 71 cases. Arch Intern Med. 1945;75:1–23.

    Google Scholar 

  4. Salfelder K, Brass K, Doehnert G, Doehnert R, Sauerteig E. Fatal disseminated histoplasmosis: anatomic study of autopsy cases. Virchows Arch A Pathol Anat. 1970;350:303–35.

    Article  PubMed  CAS  Google Scholar 

  5. Schwarz J. Mycotic prostatitis. Urology. 1982;19:1–5.

    Article  PubMed  CAS  Google Scholar 

  6. Watanabe M, Hotchi M, Nagasaki M. An autopsy case of disseminated histoplasmosis probably due to infection from a renal allograft. Acta Pathol Jpn. 1988;38:769–80.

    PubMed  CAS  Google Scholar 

  7. Sridhar NR, Tchervenkov JI, Weiss MA, Hijazi YM, First MR. Disseminated histoplasmosis in a renal transplant patient: a cause of renal failure several years following transplantation. Am J Kidney Dis. 1991;17:719–21.

    PubMed  CAS  Google Scholar 

  8. Delfino VD, Guembarovski AL, Soares AE, Gordan PA, Matni AM, Mocelin AJ. Loss of renal allograft function caused by Histoplasma capsulatum. Transplant Proc. 1995;27:1817–8.

    PubMed  CAS  Google Scholar 

  9. Davies SF, Sarosi GA, Peterson PK, Khan M, Howard RJ, Simmons RL, et al. Disseminated histoplasmosis in renal transplant recipients. Am J Surg. 1979;137:686–91.

    Article  PubMed  CAS  Google Scholar 

  10. Superdock KR, Dummer JS, Koch MO, Gilliam DM, Van Buren DH, Nylander WA, et al. Disseminated histoplasmosis presenting as urinary tract obstruction in a renal transplant recipient. Am J Kidney Dis. 1994;23:600–4.

    PubMed  CAS  Google Scholar 

  11. Wong SY, Allen DM. Transmission of disseminated histoplasmosis via cadaveric renal transplantation: case report. Clin Infect Dis. 1992;14:232–4.

    PubMed  CAS  Google Scholar 

  12. Hood AB, Inglis FG, Lowenstein L, Dossetor JB, MacLean LD. Histoplasmosis and thrombocytopenic purpura: transmission by renal homotransplantation. Can Med Assoc J. 1965;93:587–92.

    PubMed  CAS  Google Scholar 

  13. Unis G, Oliveira FdeM, Severo LC. Disseminated histoplasmosis in Rio Grande do Sul. Rev Soc Bras Med Trop. 2004;37:463–8.

    PubMed  Google Scholar 

  14. Unis G, da Silva VB, Severo LC. Disseminated histoplasmosis and AIDS. The role of culture medium for the bronchoscopic clinical specimens. Rev Soc Bras Med Trop. 2004;37:234–7.

    PubMed  Google Scholar 

  15. Ahuja TS, Remmers A, Rajaraman S, Funtanilla M. Acute renal failure in a patient with AIDS: histoplasmosis-induced granulomatous interstitial nephritis. Am J Kidney Dis. 1998;32:E3.

    Article  PubMed  CAS  Google Scholar 

  16. Ludmerer KM, Kissane JM. Fever and renal failure in a 31-year-old male with AIDS. Am J Med. 1997;102:310–5.

    Article  Google Scholar 

  17. Burke DG, Emancipator SN, Smith MC, Salata RA. Histoplasmosis and kidney disease in patients with AIDS. Clin Infect Dis. 1997;25:281–4.

    Article  PubMed  CAS  Google Scholar 

  18. Smith JW, Utz JP. Progressive disseminated histoplasmosis. A prospective study of 26 patients. Ann Intern Med. 1972;76:557–65.

    PubMed  CAS  Google Scholar 

  19. Kauffman CA, Israel KS, Smith JW, White AC, Schwarz J, Brooks GF. Histoplasmosis in immunosuppressed patients. Am J Med. 1978;64:923–32.

    Article  PubMed  CAS  Google Scholar 

  20. Vanke J, Schwartz J. The gamut of histoplasmosis. Am J Med. 1971;50:89–104.

    Article  Google Scholar 

  21. Walker JV, Baran D, Yakub N, Freeman RB. Histoplasmosis with hypercalcemia, renal failure, and papillary necrosis: confusion with sarcoidosis. JAMA. 1977;237:1350–2.

    Article  PubMed  CAS  Google Scholar 

  22. Wheat LJ, Slama TG, Eitzen HE, Kohler RB, French ML, Biesecker JL. A large urban outbreak of histoplasmosis: clinical features. Ann Intern Med. 1981;94:331–7.

    PubMed  CAS  Google Scholar 

  23. Reddy P, Gorelick DF, Brasher CA, Larsh H. Progressive disseminated histoplasmosis as seen in adults. Am J Med. 1970;48:629–36.

    Article  PubMed  CAS  Google Scholar 

  24. Kedar SS, Eldar S, Abrahamson J, Boss J. Histoplasmosis of kidneys presenting as chronic recurrent renal disease. Urology. 1988;31:490–4.

    Article  PubMed  CAS  Google Scholar 

  25. Bullock WE, Artz RP, Bhathena D, Tung KS. Histoplasmosis. Association with circulating immune complexes, eosinophilia, and mesangiopathic glomerulonephritis. Arch Intern Med. 1979;139:700–2.

    Article  PubMed  CAS  Google Scholar 

  26. Papo T, Boisnic S, Piette JC, Frances C, Beaufils H, Le TH, et al. Disseminated histoplasmosis with glomerulonephritis mimicking Wegener’s granulomatosis. Am J Kidney Dis. 1993;21:542–4.

    PubMed  CAS  Google Scholar 

  27. Binford CH. Histoplasmosis: tissue reactions and morphologic variations of the fungus. Am J Clin Pathol. 1955;25:25–36.

    PubMed  CAS  Google Scholar 

  28. Bersack SR, Howe JS, Rabson AS. Inflammatory pseudopolyposis of the small and large intestines with the Peutz-Jeghers syndrome in a case of diffuse histoplasmosis. Urology. 1958;80:73–8.

    CAS  Google Scholar 

  29. Shah RD, Nardi PM, Han CC. Histoplasma prostatic abscess: rare cause in an immunocompromised patient. AJR Am J Roentgenol. 1996;166:471.

    PubMed  CAS  Google Scholar 

  30. Zighelboim J, Goldfarb RA, Mody D, Williams TW, Bradshaw MW, Harris RL. Prostatic abscess due to Histoplasma capsulatum in a patient with the acquired immunodeficiency syndrome. J Urol. 1992;147:166–8.

    PubMed  CAS  Google Scholar 

  31. Marans HY, Mandell W, Kislak JW, Starrett B, Moussouris HF. Prostatic abscess due to Histoplasma capsulatum in the acquired immunodeficiency syndrome. J Urol. 1991;145:1275–6.

    PubMed  CAS  Google Scholar 

  32. Orr WA, Mulholland SG, Walzak MP. Genitourinary tract involvement with systemic mycosis. J Urol. 1972;107:1047–50.

    PubMed  CAS  Google Scholar 

  33. Miller AA, Ramsden F, Geake MR. Acute disseminated histoplasmosis of pulmonary origin probably contracted in Britain. Thorax. 1961;16:388–94.

    Article  PubMed  CAS  Google Scholar 

  34. Mawhorter SD, Curley GV, Kursh ED, Farver CE. Prostatic and central nervous system histoplasmosis in an immunocompetent host: case report and review of the prostatic histoplasmosis literature. Clin Infect Dis. 2000;30:595–8.

    Article  PubMed  CAS  Google Scholar 

  35. Reddy PA, Sutaria M, Brasher CA, Christianson CS. Disseminated histoplasmosis: cutaneous (subcutaneous abscess), vesical and prostatic histoplasmosis. South Med J. 1970;63:819–21.

    PubMed  CAS  Google Scholar 

  36. Rubin H, Furcolow ML, Yates JL. The course and prognosis of histoplasmosis. Am J Med. 1959;27:278–88.

    Article  PubMed  CAS  Google Scholar 

  37. Aach R, Kissane J. Clinicopathologic conference. Chronic lymphocytic leukemia complicated by disseminated histoplasmosis. Am J Med. 1967;43:593–603.

    Article  Google Scholar 

  38. Schuster TG, Hollenbeck BK, Kauffman CA, Chensue SW, Wei JT. Testicular histoplasmosis. J Urol. 2000;164:1652.

    Article  PubMed  CAS  Google Scholar 

  39. Boone WT, Allison F Jr. Histoplasmosis. Am J Med. 1969;46:818–26.

    Article  PubMed  CAS  Google Scholar 

  40. Kauffman CA, Slama TG, Wheat LJ. Histoplasma capsulatum epididymitis. J Urol. 1981;125:434–5.

    PubMed  CAS  Google Scholar 

  41. Monroe M. Granulomatous orchitis due to Histoplasma capsulatum masquerading as sperm granuloma. J Clin Pathol. 1974;27:929–30.

    Article  PubMed  CAS  Google Scholar 

  42. Randhawa HS, Chaturvedi S, Khan ZU, Chaturvedi VP, Jain SK, Jain RC, et al. Epididymal histoplasmosis diagnosed by isolation of Histoplasma capsulatum from semen. Mycopathologia. 1995;131:173–7.

    Article  PubMed  CAS  Google Scholar 

  43. Preminger B, Gerard PS, Lutwick L, Frank R, Minkowitz S, Plotkin N. Histoplasmosis of the penis. J Urol. 1993;149:848–50.

    PubMed  CAS  Google Scholar 

  44. Jayalakshmi P, Goh KL, Soo-Hoo TS, Daud A. Disseminated histoplasmosis presenting as penile ulcer. Aust N Z J Med. 1990;20:175–6.

    PubMed  CAS  Google Scholar 

  45. Curtis AC, Cawley EP. Genital histoplasmosis. J Urol. 1947;57:781–7.

    Google Scholar 

  46. Palmer AE, Amolsch AL, Shaffer LW. Histoplasmosis with mucocutaneous manifestations. Arch Derm Syphilol. 1942;45:912–6.

    Google Scholar 

  47. Nayak RG, Ramnaryayan K, Rao RV, Shenoy MG. A case of histoplasma posthitis. Trop Geogr Med. 1984;36:309–11.

    PubMed  CAS  Google Scholar 

  48. Mankodi RC, Kanvinde MS, Mohapatra LN. Penile histoplasmosis: a case report. Indian J Med Sci. 1970;24:354–6.

    PubMed  CAS  Google Scholar 

  49. Talvalkar GV. Histoplasmosis simulating carcinoma. A report of three cases. Indian J Cancer. 1972;9:149–53.

    PubMed  CAS  Google Scholar 

  50. Sills M, Schwartz A, Weg JG. Conjugal histoplasmosis: a consequence of progressive dissemination in the index case after steroid therapy. Ann Intern Med. 1973;79:221–4.

    PubMed  CAS  Google Scholar 

  51. Gass M, Kobayashi GS. Histoplasmosis. An illustrative case with unusual vaginal and joint involvement. Arch Dermatol. 1969;100:724–7.

    Article  PubMed  CAS  Google Scholar 

  52. Smith MB, Schnadig VJ, Zaharopoulos P, Van Hook C. Disseminated Histoplasma capsulatum infection presenting as genital ulcerations. Obstet Gynecol. 1997;89:824–42.

    Article  Google Scholar 

  53. Conrad FG, Saslaw S, Atwell RJ. The protean manifestations of histoplasmosis as illustrated in twenty-three cases. Arch Intern Med. 1959;104:692–709.

    PubMed  CAS  Google Scholar 

  54. Friskel E, Klotz SA, Bartholomew W, Dixon A. Two unusual presentations of urogenital histoplasmosis and a review of the literature. Clin Infect Dis. 2000;31:189–91.

    Article  PubMed  CAS  Google Scholar 

  55. Mukunyadzi P, Johnson M, Wyble JG, Scott M. Diagnosis of histoplasmosis in urine cytology: reactive urothelial changes, a diagnostic pitfall. Case report and literature review of urinary tract infections. Diagn Cytopathol. 2002;26:243–6.

    Article  PubMed  Google Scholar 

  56. Isotalo PA, McCarthy AE, Eidus L. Ovarian histoplasmosis in systemic lupus erythematosus. Pathology. 2000;32:139–41.

    Article  PubMed  CAS  Google Scholar 

  57. Limaye AP, Connolly PA, Sagar M, Fritsche TR, Cookson BT, Wheat LJ, et al. Transmission of Histoplasma capsulatum by organ transplantation. N Engl J Med. 2000;343:1163–6.

    Article  PubMed  CAS  Google Scholar 

  58. Wheat LJ. Laboratory diagnosis of histoplasmosis: update 2000. Semin Respir Infect. 2001;16:131–40.

    Article  PubMed  CAS  Google Scholar 

  59. Wheat LJ, Connolly-Stringfield P, Blair R, Connolly K, Garringer T, Katz BP, et al. Effect of successful treatment with amphotericin B on Histoplasma capsulatum variety capsulatum polysaccharide antigen levels in patients with AIDS and histoplasmosis. Am J Med. 1992;92:153–60.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Dr Pasqualotto receives a grant from CAPES (Brazilian government).

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Authors and Affiliations

  1. School of Medicine, The University of Manchester, Manchester, UK

    Alessandro C. Pasqualotto

  2. Post-graduation Program in Pulmonary Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

    Alessandro C. Pasqualotto, Flavio M. Oliveira & Luiz Carlos Severo

  3. Educational and Research Centre, Wythenshawe Hospital, 2nd Floor, Manchester, M23 9LT, UK

    Alessandro C. Pasqualotto

  4. Mycology Laboratory, Santa Casa Complexo Hospitalar, Porto Alegre, Brazil

    Flavio M. Oliveira & Luiz Carlos Severo

  5. Department of Internal Medicine, UFRGS, Porto Alegre, Brazil

    Luiz Carlos Severo

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  1. Alessandro C. Pasqualotto
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  2. Flavio M. Oliveira
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Correspondence to Alessandro C. Pasqualotto.

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Pasqualotto, A.C., Oliveira, F.M. & Severo, L.C. Histoplasma capsulatum Recovery from the Urine and a Short Review of Genitourinary Histoplasmosis. Mycopathologia 167, 315–323 (2009). https://doi.org/10.1007/s11046-009-9182-z

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