Abstract
The aim of this study is to determine lipid peroxidation and antioxidant enzyme levels in spleen and testis tissues of guinea pigs which were exposed to different intensities and periods of DC (direct current) and AC (alternating current) electric fields. The experimental results are applied to neural networks as learning data and the training of the feed forward neural network is realized. At the end of this training; without applying electric field to the tissues, the determination of the effects of the electric field on tissues by using computer is predicted by the neural network. After the experiments, the prediction of the neural network is averagely 99%.
Similar content being viewed by others
References
Barriviera, M. L., Louro, S. R. W., Wajnberg, E., and Hasson-Voloch, A., Denervation alters protein-lipid interactions in membrane fractions from electrocytes of Electrophorus electrius (L.). Biophys. Chem. 91:93–104, 2001.
Benov, L. C., Antonov, P. A., and Ribarov, S. R., Oxidative damage the membrane lipids after electroporation. Gen. Physiol. Biophys. 13:85–97, 1994.
Güler, G., Seyhan Atalay, N., Özoğul, C., and Erdoğan, D., Biochemical and structural approach to collagen synthesis under electric fields. Gen. Physiol. Biophys. 15:429–440, 1996.
Irmak, M. K., Fadillioğlu, E., Güleç, M., Erdoğan, H., Yağmurcu, M., and Akyol, Ö., Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits. Cell Biochem. Funct. 20:1–5, 2002.
Wright, I. A., and Gough, N. A. J., Artificial neural network analysis of common femoral artery Doppler shift signals: Classification of proximal disease. Ultrasound Med. Biol. 24:735, 1999.
Beale, R., and Jackson, T., Neural Computing: An Introduction, Institute of Physics Publishing, Bristol, UK, 1990.
Fredric, M. H., and Inica, K., Principles of Neurocomputing for Science and Engineering, McGraw-Hill, New York, 2001.
McClelland, J. L., and Rumelhart, D. E., Explorations in Parallel Distributed Processing: A Handbook of Models, Programs and Exercises, Cambridge, 1986.
Ebeigbe, A. B., Gantzos, R. D., and Webb, R. C., Relaxation of rat tail artery to electrical stimulation. Life Sci. 33:303–309, 1983.
Lamb, F. S., and Webb, R. C., Vascular effects of free radicals generated by electrical stimulation. Am. J. Physiol. 247:H709–H714, 1984.
Sanguinetti, C. M., Oxidant/antioxidant imbalance: Role in the pathogenesis of COPD. Respiration 59:20–23, 1992.
Gutteridge, J. M. C., Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem. 41:1819–1828, 1995.
Maccall, J. M., Braughler, J. M. and Hall, E. D., Lipid peroxidation and the role of oxygen radicals in CNS injury. Acta. Anaesthesiologica Belgica 38:373–379, 1987.
Wasowics, W., Neve, S., and Peretz, A., Optimized steps in fluorometric determination of thiobarbituric acid reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin. Chem. 39:2522–2526, 1993.
Desideri, A., Falconi, M., Polticelli, F., Bolognesi, M., Djnovic, K., and Rotilio, G., Evolutionary conservativeness of electric field in the Cu,Zn superoxide dismutase active site, Evidence for co-ordinated mutation of charged amino acid residues. J. Mol. Biol. 223:337–342, 1992.
Osman, R., Effect of local environment and protein on the mechanism of action of superoxide dismutase. Enzyme 36:32–42, 1986.
Salo, D. C., Pacifici, R. E., Lin, S. W., Giulivi, C., and Davies, K. J. A., Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation. J. Biol. Chem. 265:1919–1927, 1990.
Scaiano, J. C., Mohtat, N., Cozens, F. L., Mclean, J., and Thansandote, A., Application of the radical pair mechanism to free radicals in organized systems: Can the effects of 60 Hz br predicted from studies under static fields? Bioelectromagnetics 5:549–554, 1994.
Lowry, O. H., Rosebrough, N. I., Farr, A. L., and Randall, R. J., Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265–275, 1951.
Sun, Y., Oberley, L. W., and Li, Y., A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34:497–500, 1988.
Cozen, F. L., and Scaiano, J. C., A compatative study of magnetic field effects on the dynamics of geminate and random radical pair processes in micelles. J. Am. Chem. Soc. 115:5204–5211, 1993.
Romodanova, E. A., Paranich, A. V., and Chaikina, L. A., Effect of chronic effect of the electrostatic field on various biochemical indicators of tissues. Fiziol. Zh. 36:30–34, 1990.
Blank, M., Electromagnetic Fields, Biological Interactions and Mechanisms, Advances in Chemistry Series 250, Washington, 1995.
Margonato, V., Veicsteinas, A., Conti, R., Nicolini, P., and Cerretelli, P., Biologic effects of prolonged exposure to ELF electrmagnetic fields in rats I. 50 Hz electric fields. Bioelectromagnetics 14:479–493, 1993.
Marino, A. A., Berger, T. J., Mitchell, J. T., Duhacek, B. A., and Becker, R., Electric field effects in selected biologic systems. Ann. N. Y. Acad. Sci. 405:436–444, 1983.
Marino, A. A., Morris, D. M., and Arnold, T., Electrical treatment of lewis lung carcinoma in mice. J. Surg. Res. 41:198–201, 1986.
Rodan, G., Bourret, L. A., and Norton, L. A., DNA synthesis in cartilage cells is stimulated by oscillating electric fields. Science 199:690–692, 1978.
Güler, G., and Seyhan Atalay, N., Functional enzymes of liver, total blood protein and albumin levels under electric fields, medical & biological engineering & computing. World Congress on Medical Physics and Biomedical Engineering, Suppl. 1, pp. 45, Nice, September 14–19, 1997.
Güler, G. and Seyhan Atalay, N., Changes in hydroxyproline levels in electric field tissue interaction. Indian J. Biochem. Bio. 33:531–533, 1996.
Güler, G. and Seyhan Atalay, N., The effect of vertical and horizontal electric fields on collagen synthesis, progress in biophysics & molecular biology, XIIth International Biophysics Congress, 65 Suppl.1, p. 215, Amsterdam, 11–16 August, 1996.
Author information
Authors and Affiliations
Corresponding author
Additional information
An erratum to this article is available at http://dx.doi.org/10.1007/s10916-008-9189-x.
Rights and permissions
About this article
Cite this article
Güler, G., Hardalaç, F. & Arıcıoğlu, A. Examination of Electric Field Effects on Tissues by Using Back Propagation Neural Network. J Med Syst 29, 679–708 (2005). https://doi.org/10.1007/s10916-005-6356-1
Issue Date:
DOI: https://doi.org/10.1007/s10916-005-6356-1