Abstract
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination. The mean life span of animals exposed to constant or natural illumination decreased by 13.5 and 25.5%, the maximum by 9 and 7 months, respectively, and spontaneous tumors developed much more rapidly than in animals living under conditions of the standard light regimen. Epithalon (0.1 µg daily 5 times a week from the age of 4 months) did not change the life span of rats living under conditions of standard day/night regimen, while in rats exposed to the natural and constant light it promoted prolongation of the maximum life span by 95 and 24 days, respectively. Epithalon prolonged the mean life span of the last 10% of rats exposed to natural and constant illumination, treated with Epithalon, by 137 and 43 days, respectively. This peptide exhibited virtually no effect on the development of spontaneous tumors in rats exposed to standard and constant illumination, but significantly inhibited their development in rats exposed to natural light.
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References
V. N. Anisimov and I. A. Vinogradova, Vopr. Onkol., 53, No. 5, 491–498 (2006).
I. A. Vinogradova and I. V. Chernova, Uspekhi Gerontol., 19, 60–65 (2006).
E. V. Ivanter and A. V. Korosov, Introduction to Quantitative Biology [in Russian], Petrozavodsk (2003).
V. A. Ilyukha, I. A. Vinogradova, A. S. Fedorova, and A. N. Vel’b, Med. Akad. Zh., 3, Suppl. 7, 18–20 (2005).
V. Kh. Khavinson, S. V. Anisimov, V. V. Malinin, and V. N. Anisimov, Peptide Regulation of Genome and Aging [in Russian], Moscow (2005).
V. I. Khasnulin, I. I. Chechetkina, P. V. Khasnulin, et al., Ekol. Chel., Suppl. 4/1, 16–21 (2006).
V. N. Anisimov, Neuro Endocrinol. Lett., 27, Nos. 1–2, 35–52 (2006).
V. N. Anisimov, I. G. Popovich, M. A. Zabezhinski, et al., Biochim. Biophys. Acta, 1757, Nos. 5–6, 573–589 (2006).
D. R. Cox and D. Oakes, Analysis of Survival Data, London (1996).
J. J. Gart, D. Krewski, P. N. Lee, et al., IARC Sci. Publ., 79, 1–219 (1986).
Gauss System and Graphic Manual, Maple Valley WA: Aptech Systems, Inc. (1994).
A. Knutsson, Occup. Med. (London), 53, No. 2, 103–108 (2003).
S. M. Pauley, Med. Hypotheses, 63, No. 4, 588–596 (2004).
R. G. Stevens, Cancer Causes Control, 17, No. 4, 501–507 (2006).
V. S. Turusov and S. Ivankovic, IARC Sci. Publ., 99, 725–739 (1990).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 676–681, December, 2007
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Vinogradova, I.A., Bukalev, A.V., Zabezhinski, M.A. et al. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. Bull Exp Biol Med 144, 825–830 (2007). https://doi.org/10.1007/s10517-007-0441-z
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DOI: https://doi.org/10.1007/s10517-007-0441-z