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Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale

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Abstract

An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.

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Authors and Affiliations

  1. Lawrence Berkeley National Laboratory, University of California, Berkeley, CA, USA

    Thomas F. Budinger

  2. National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA

    Mark D. Bird, Lucio Frydman & Victor D. Schepkin

  3. Weizmann Institute, Rehovot, Israel

    Lucio Frydman

  4. McKnight Brain Institute, University of Florida, Gainesville, FL, USA

    Joanna R. Long & Thomas H. Mareci

  5. Oregon Health and Sciences University, Portland, OR, USA

    William D. Rooney & Charles S. Springer

  6. Massachusetts General Hospital, Harvard Medical School, Harvard, MA, USA

    Bruce Rosen & Lawrence L. Wald

  7. General Electric Corporate Research, Schenectady, NY, USA

    John F. Schenck

  8. University of Texas Southwestern Medical Center, Dallas, TX, USA

    A. Dean Sherry

  9. School of Medicine, New York University, New York, NY, USA

    Daniel K. Sodickson

  10. University of Minnesota, Minneapolis, MN, USA

    Kamil Uğurbil

  11. University of Illinois, Chicago, IL, USA

    Keith R. Thulborn

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Budinger, T.F., Bird, M.D., Frydman, L. et al. Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale. Magn Reson Mater Phy 29, 617–639 (2016). https://doi.org/10.1007/s10334-016-0561-4

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  • DOI: https://doi.org/10.1007/s10334-016-0561-4

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