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Placentophagy: therapeutic miracle or myth?

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Abstract

Postpartum women are consuming their placentas encapsulated, cooked, and raw for the prevention of postpartum depression (PPD), pain relief, and other health benefits. Placentophagy is supported by health advocates who assert that the placenta retains hormones and nutrients that are beneficial to the mother. A computerized search was conducted using PubMed, Medline Ovid, and PsychINFO between January 1950 and January 2014. Keywords included placentophagy, placentophagia, maternal placentophagia, maternal placentophagy, human placentophagia, and human placentophagy. A total of 49 articles were identified. Empirical studies of human or animal consumption of human placentas were included. Editorial commentaries were excluded. Animal placentophagy studies were chosen based on their relevance to human practice. Ten articles (four human, six animal) were selected for inclusion. A minority of women in developed countries perceive placentophagy to reduce PPD risk and enhance recovery. Experimental animal research in support of pain reduction has not been applied in humans. Studies investigating placenta consumption for facilitating uterine contraction, resumption of normal cyclic estrogen cycle, and milk production are inconclusive. The health benefits and risks of placentophagy require further investigation of the retained contents of raw, cooked, and encapsulated placenta and its effects on the postpartum woman.

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References

  • Aagard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J (2014) The placenta harbors a unique microbiome. Sci Transl Med 6(237):1–11

    Article  Google Scholar 

  • Abbott P, Thompson AC, Ferguson EJ, Doerr JC, Tarapacki JA, Kostyniak PJ, Syracuse JA, Cartonia DM, Kristal MB (1991) Placental opioid-enhancing factor (POEF): generalizability of effects. Physiol Behav 50(5):933–940

    Article  CAS  PubMed  Google Scholar 

  • Ahokas A, Kaukoranta J, Wahlbeck K, Aito M (2001) Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study. J Clin Psychiatry 62(5):332–336

    Article  CAS  PubMed  Google Scholar 

  • Annoni M (2013) Highlights from the 2013 Science of Placebo Thematic Workshop. Ecancer Med Sci 7:346

    Google Scholar 

  • Apari P, Rozsa L (2006) Deal in the womb: fetal opiates, parent offspring, conflict, and the future of midwifery. Med Hypotheses 67(5):1189–1194

    Article  PubMed  Google Scholar 

  • Banker JE, LaCoursiere DY (2014) Postpartum depression: risks, protective factors, and the couple’s relationship. Issues Ment Health Nurs 35:503–508

    Article  PubMed  Google Scholar 

  • Beacock M (2012) Does eating placenta offer postpartum health benefits? Br J Midwif 20(7):464–469

    Article  Google Scholar 

  • Beck CT (2001) Predictors of postpartum depression: an update. Nurs Res 50(5):275–285

    Article  CAS  PubMed  Google Scholar 

  • Benedetti F, Carlino E, Pollo A (2011) How placebos change the patient’s brain. Neuropsychopharmacology 36:339–354

    Article  PubMed Central  PubMed  Google Scholar 

  • Blank MS, Friesen HG (1980) Effects of placentophagy on serum prolactin and progesterone concentrations in rats after parturition or superovulation. J Reprod Fertil 60(2):273–278

    Article  CAS  PubMed  Google Scholar 

  • Bloch M, Daley RC, Rubinow DR (2003) Endocrine factors in the etiology of postpartum depression. Compr Psychiatry 44(3):234–246

    Article  PubMed  Google Scholar 

  • Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR (2000) Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 157(6):924–930

    Article  CAS  PubMed  Google Scholar 

  • Bradley J, Leibold EA, Harris ZL, Wobken JD, Clarke S, Zumbrennen KB, Eisenstein RS, Georgieff MK (2004) Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta. Am J Physiol Regul Integr Comp Physiol 287(4):R894–R901

    Article  CAS  PubMed  Google Scholar 

  • Corpening JW, Doerr JC, Kristal MB (2004) Ingested placenta blocks the effect of morphine on gut transit in Long-Evans rats. Brain Res 1016(2):217–221

    Article  CAS  PubMed  Google Scholar 

  • Cremers GE, Low KG (2014) Attitudes toward placentophagy: a brief report. Health Care Women Int 35(2):113–119

    Article  PubMed  Google Scholar 

  • Curtis L (n.d.) Placenta wise. http://www.placentawise.com/faq. Accessed 15 Sept 2013

  • Dipirro JM, Kristal MB (2004) Placenta ingestion by rats enhances δ- and κ- opioid antinociception. Brain Res 1014(1–2):22–33

    Article  CAS  PubMed  Google Scholar 

  • Geers AL, Rose JP, Fowler SL, Rasinski HM, Brown JA, Helfer SG (2013) Why does choice enhance treatment effectiveness? Using placebo treatments to demonstrate the role of personal control. J Pers Soc Psychol 105(4):549–566

    Article  PubMed  Google Scholar 

  • Gregoire AJ, Kumar R, Everitt B, Henderson AF, Studd JW (1996) Transdermal oestrogen for treatment of severe postnatal depression. Lancet 347(9006):930–933

    Article  CAS  PubMed  Google Scholar 

  • Iyengar GV, Rapp A (2001) Human placenta as a ‘dual’ biomarker for monitoring fetal and maternal environment with special reference to potentially toxic trace elements. Part 3: toxic trace elements in placenta and placenta as a biomarker for these elements. Sci Total Environ 280(1–3):221–238

    Article  CAS  PubMed  Google Scholar 

  • Kirsch I, Kong J, Sadler P, Spaeth R, Cook A, Kaptchuk TJ (2014) Expectancy and conditioning in placebo analgesia: separate or connected processes? Psychol Conscious (Am Psychol Assoc) 1(1):51–59

    Google Scholar 

  • Kristal MB (1991) Enhancement of opioid-mediated analgesia: a solution to the enigma of placentophagia. Neurosci Biobehav Rev 15(3):425–435

    Article  CAS  PubMed  Google Scholar 

  • Kristal MB, Abbott P, Thompson AC (1988) Dose-dependent enhancement of morphine-induced analgesia by ingestion of amniotic fluid and placenta. Pharmacol Biochem Behav 31(2):351–356

    Article  CAS  PubMed  Google Scholar 

  • Kristal MB, DiPirro JM, Thompson AC (2012) Placentophagia in humans and nonhuman mammals: causes and consequences. Ecol Food Nutr 51(3):177–197

    Article  PubMed  Google Scholar 

  • Llanos MN, Ronco AM (2009) Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities. Reprod Toxicol 27(1):88–92

    Article  CAS  PubMed  Google Scholar 

  • Mann PE, Kinsley CH, Bridges RS (1991) Opioid receptor subtype involvement in maternal behavior in lactating rats. Neuroendocrinology 53(5):487–492

    Article  CAS  PubMed  Google Scholar 

  • Myllynen P, Pasanen M, Pelkonen O (2005) Human placenta: a human organ for developmental toxicology research and biomonitoring. Placenta 26(5):361–371

    Article  CAS  PubMed  Google Scholar 

  • Ober WB (1979) Notes on placentophagy. Bull N Y Acad Med 55(6):591–599

    PubMed Central  CAS  PubMed  Google Scholar 

  • Okun ML, Luther J, Prather AA, Perel JM, Wisniewski S, Wisner KL (2011) Changes in sleep quality but not hormones predict time to postpartum depression recurrence. J Affect Disord 130(3):378–384

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Onuaguluchi G, Ghasi S (1996) The pharmacological basis for the use of dried sheep placenta in traditional obstetric practice in Nigeria. J Ethnopharmacol 54:27–36

    Article  CAS  PubMed  Google Scholar 

  • Osman K, Akesson A, Berglund M, Bremme K, Schütz A, Ask K, Vahter M (2000) Toxic and essential elements in placentas of Swedish women. Clin Biochem 33(2):131–138

    Article  CAS  PubMed  Google Scholar 

  • Piasek M, Blanusa M, Kostial K, Laskey JW (2001) Placental cadmium and progesterone concentrations in cigarette smokers. Reprod Toxicol 15(6):673–681

    Article  CAS  PubMed  Google Scholar 

  • Robinson P (2015) Heal thyself! Pat Robinson.http://healthyself.ning.com/profiles/blogs/placental-encapsulation. Accessed 10 Sept 2013

  • Selander J, Cantor A, Young SM, Benyshek DC (2013) Human maternal placentophagy: a survey of self-reported motivations and experiences associated with placenta consumption. Ecol Food Nutr 52(2):93–115

    Article  PubMed  Google Scholar 

  • Selander J (2006–2015) Placenta benefits.info. Placenta Benefits Ltd. http://placentabenefits.info/articles/asp. Accessed 2 Sept 2013

  • Shizhen L, Xiwen L (1593) Clause 52–29: Renbao (human placenta). [In Chinese]. In: Kaimin H, Yousheng (eds) Compendium of materia medica: bencao gangmu. Vol 6, 1st edn. Foreign Language Press, Beijing, pp 4182–4186

    Google Scholar 

  • Sora I, Funada M, Uhl GR (1997) The mu-opioid receptor is necessary for [D-Pen2, D-Pen5] enkephalin-induced analgesia. Eur J Pharmacol 324(2–3):R1–R2

    Article  CAS  PubMed  Google Scholar 

  • Soyková-Pachnerová E, Brutar V, Golová B, Zvolská (1954) Placenta as a lactagogon. Gynaecologia 138(6):617–627

    PubMed  Google Scholar 

  • Sugahara M, Makino T, Suzuki H, Nakamua J, Iizuka R (1985) Immunoreactive oxytocin synthesis in human placental tissue. Endocrinol Jpn 32(6):917–920

    Article  CAS  PubMed  Google Scholar 

  • Wisner KL, Stowe ZN (1997) Psychobiology of mood disorders. Semin Reprod Endocrinol 15(1):77–89

    Article  CAS  PubMed  Google Scholar 

  • Young SM, Benyshek DC, Lienard P (2012) The conspicuous absence of placenta consumption in human postpartum females: the fire hypothesis. Ecol Food Nutr 51:198–217

    Article  PubMed  Google Scholar 

  • Young SM, Benyshek DC (2010) In search of human placentophagy: a cross-cultural survey of human placenta consumption, disposal practices, and cultural beliefs. Ecol Food Nutr 49(6):467–484

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to acknowledge Stephanie A. Schuette and Barbara Sutcliffe who assisted with the formatting for this manuscript. The Department of Psychiatry at Northwestern University receives contractual fees for Dr. Katherine L. Wisner’s consultation to Quinn Emanuel Urquhart & Sullivan, LLP (New York City), who represent Pfizer Pharmaceutical Company. Dr. Crystal T. Clark is supported in part by Grant Number K12 HD055884 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Dr. Kara E. Driscoll is a medical advisor for the development of EMMI Solutions postpartum depression program.

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Authors and Affiliations

  1. Asher Center for the Study and Treatment of Depressive Disorders, Department of Psychiatry, Northwestern University Feinberg School of Medicine, 676 St. Clair, Suite 1000, Chicago, IL, 60611, USA

    Cynthia W. Coyle, Katherine L. Wisner, Kara E. Driscoll & Crystal T. Clark

  2. Division of Allergy – Immunology, Northwestern University Feinberg School of Medicine, 251 East Huron Street, Galter Suite 3-150, Chicago, IL, 60611, USA

    Kathryn E. Hulse

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  1. Cynthia W. Coyle
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  2. Kathryn E. Hulse
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  3. Katherine L. Wisner
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  4. Kara E. Driscoll
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  5. Crystal T. Clark
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Correspondence to Crystal T. Clark.

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Coyle, C.W., Hulse, K.E., Wisner, K.L. et al. Placentophagy: therapeutic miracle or myth?. Arch Womens Ment Health 18, 673–680 (2015). https://doi.org/10.1007/s00737-015-0538-8

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  • DOI: https://doi.org/10.1007/s00737-015-0538-8

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