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Lithium Tetrafluoroborate–Catalyzed Solventless Synthesis of α-Aminonitriles

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Summary.

Lithium tetrafluoroborate-catalyzed one-pot, highly efficient, and solvent-free protocol has been developed for the synthesis of α-aminonitriles from aldehydes/ketones, amines, and trimethylsilyl cyanide.

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References

  • G Dyker (1997) Angew Chem Int Ed Engl 36 1700 Occurrence Handle10.1002/anie.199717001 Occurrence Handle1:CAS:528:DyaK2sXmtVSjsrY%3D

    Article  CAS  Google Scholar 

  • a) Weinstock LM, Davis P, Handelsman B, Tull R (1967) J Org Chem 32: 2823; b) Maiter WL, Owens DA, Comer WT, Deitchman D, Ferguson HC, Seidehamel RJ, Young JR (1973) J Med Chem 16: 901

    Google Scholar 

  • YM Shafran VA Bakulev VS Mokrushin (1989) Russ Chem Rev 58 148 Occurrence Handle10.1070/RC1989v058n02ABEH003432

    Article  Google Scholar 

  • a) Mai K, Patil G (1984) Tetrahedron Lett 25: 4583; b) Harusawa S, Hamada Y, Shiori T (1979) Tetrahedron Lett 20: 4663; c) Iyer MS, Gigstad M, Namdev ND, Lipton M (1996) J Am Chem Soc 118: 4910; d) Takamura M, Hamishima Y, Usuda H, Kanai M, Shibasaki M (2000) Angew Chem Int Ed Engl 39: 1650

  • a) Qian C, Huang T (1998) J Org Chem 63: 4125; b) Kobayashi S, Ishitani H, Ueno M (1997) Synlett: 115; c) De SK (2005) Synth Commun 35: 1577 and references cited therein; d) Sudalai A, Paraskar A (2006) Tetrahedron Lett 47: 5759

  • A Heydari P Fatemi A Alizadeh (1998) Tetrahedron Lett 39 3049 Occurrence Handle10.1016/S0040-4039(98)00354-2 Occurrence Handle1:CAS:528:DyaK1cXjtVylsb0%3D

    Article  CAS  Google Scholar 

  • L Royer SK De RA Gibbs (2004) Tetrahedron Lett 46 5495

    Google Scholar 

  • a) De SK (2005) Synth Commun 35: 653; b) De SK, Gibbs RA Tetrahedron Lett (2004) 45: 7407; c) De SK (2005) Beil J Org Chem 1: 8; d) Ranu BC, Hajra A, Jana U (2002) Tetrahedron 58: 2529

  • Das B, Ramu R, Ravikant B, Reddy KK (2006) Synthesis: 1419

  • S Kobayashi M Araki M Yasuda (1995) Tetrahedron Lett 36 5773 Occurrence Handle1:CAS:528:DyaK2MXnsVymsb4%3D

    CAS  Google Scholar 

  • BB Sobhana KK Balsubramamian (2000) Acros Org Acta 7 1–3

    Google Scholar 

  • G Jenner (1999) Tetrahedron Lett 40 491 Occurrence Handle10.1016/S0040-4039(98)02419-8 Occurrence Handle1:CAS:528:DyaK1MXpvVentA%3D%3D

    Article  CAS  Google Scholar 

  • JS Yadav BVS Reddy B Eeshwaraiah M Srinivas (2004) Tetrahedron 60 1767 Occurrence Handle10.1016/j.tet.2003.12.043 Occurrence Handle1:CAS:528:DC%2BD2cXpvFCntw%3D%3D

    Article  CAS  Google Scholar 

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Correspondence to Uday V. Desai.

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Desai, U., Mitragotri, S., Thopate, T. et al. Lithium Tetrafluoroborate–Catalyzed Solventless Synthesis of α-Aminonitriles. Monatsh. Chem. 138, 759–762 (2007). https://doi.org/10.1007/s00706-007-0675-5

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  • DOI: https://doi.org/10.1007/s00706-007-0675-5

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