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In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention

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International Journal of Colorectal Disease Aims and scope Submit manuscript

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Abstract

Purpose

Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan; it ranks top three in the cancer mortality rate. Curcuminoids are derived from the rhizome of Curcuma longa. It has shown anti-cancer activity and apoptosis induction in a variety of cancer cell lines. This aims to study the potential of Poloxamer 407 as the thermogelling and mucoadhesive polymer for development of a site-targeting delivery system to enhance the localized delivery of curcuminoids to the colorectal cells for CRC chemotherapy.

Methods

The mucoadhesive strength and rheological properties were measured as a function of poloxamer loaded with curcuminoids.

Results

The gelation temperature of Poloxamer 407 was found to vary with its concentration and start gelling at 37°C at the concentration of 15.5% (w/v). To ensure gelation at physiological temperature after intra-rectal application, gelation temperature was determined by rheological measurement as well as by its physical appearance. The results indicated that its mucoadhesive strength also shows a dependency on temperature, which appears to be related to the increment in the maximum strength and average strength of the polymer.

Conclusion

The results have suggested that Poloxamer 407 could be a potential thermogelling and mucoadhesive polymer for the development of a site-targeting colorectal drug delivery system for curcuminoids in colorectal cancer therapy.

Poloxamer 407 could be a potential polymer for the development of a site-targeting colorectal drug delivery system (DDS) for curcuminoids in colorectal cancer therapy.

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Acknowledgment

The authors appreciate the funding support provided by the National Science Council (Taiwan) (grant NSC94-2745-B-037-011-URD) and (NSC100-2313-B-309-001). The authors are also grateful to the technical assistance provided by Prof. YIE W. CHIEN of InnovaTherapeutics Research Center in Kaohsiung Medical University.

Conflict of interest

There is no conflict of interest.

Author information

Authors and Affiliations

  1. Division of Traumatology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan

    Ming-Jenn Chen

  2. Department of Obstetrics and Gynecology, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Ya-Min Cheng

  3. Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

    Pei-Heng Lai

  4. Department of Nutrition and Health Sciences, College of Health Sciences Chang Jung Christian University, Tainan, Taiwan

    June-Fu Wu

  5. Graduate Institute of Medical Science, and Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, Tainan, Taiwan

    Yi-Chiang Hsu

Authors
  1. Ming-Jenn Chen
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  2. Ya-Min Cheng
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  3. Pei-Heng Lai
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  4. June-Fu Wu
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Correspondence to Yi-Chiang Hsu.

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Chen, MJ., Cheng, YM., Lai, PH. et al. In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention. Int J Colorectal Dis 27, 869–878 (2012). https://doi.org/10.1007/s00384-011-1393-3

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  • DOI: https://doi.org/10.1007/s00384-011-1393-3

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