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Empathy and aggression: two faces of ecstasy? A study of interpretative cognitive bias and mood change in ecstasy users

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Abstract

Rationale

As central 5-hydroxytryptamine (5-HT) is attenuated for a period following a single dose of MDMA (“ecstasy”) and low 5-HT is associated with aggression, then MDMA users may be more aggressive in the days following an acute dose of the drug.

Objective

This study therefore aimed to determine if acute use of MDMA is associated with aggression 4 and 7 days later.

Methods

Twenty-nine MDMA users and 32 controls were compared on self-rated aggression and depression on the night of drug use (day 0), 4 and 7 days later. On day 4, participants performed an interpretative bias task in which they processed ambiguous sentences that could be interpreted in either an aggressive or neutral way (e.g. “The painter drew the knife”).

Results

MDMA users had faster response times in completing ambiguous aggressive sentences than neutral sentences; controls showed the opposite pattern of performance. In a subsequent recognition task, MDMA users were more confident in judging, and responded faster to, aggressive than neutral sentences; controls again showed the opposite pattern of effects. The level of aggressive interpretative bias positively correlated with extent of MDMA use. Midweek, MDMA users had higher self-rated aggression and depression scores than controls; on day 7, scores of both groups were similar.

Conclusions

MDMA users display a cognitive bias towards interpreting ambiguous information in an aggressive way a few days after taking the drug. Self-rated mid-week low mood and mid-week aggression do not persist 7 days after use of the drug. This pattern of results is consistent both with the acute and residual effects of MDMA on central 5-HT and with the notion that 5-HT plays a role in modulating human aggression.

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Acknowledgements

None of the authors have any interest, financial or otherwise, that might potentially bias their work. We thank Dr. Suzanne Verheyden for comments on an earlier draft of this article.

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Authors and Affiliations

  1. Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1 6BT, UK

    H. Valerie Curran, Huw Rees, Thomas Hoare & Rosa Hoshi

  2. National Addiction Centre, Institute of Psychiatry, London, UK

    Alyson Bond

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  1. H. Valerie Curran
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  2. Huw Rees
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  3. Thomas Hoare
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  4. Rosa Hoshi
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  5. Alyson Bond
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Correspondence to H. Valerie Curran.

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Curran, H.V., Rees, H., Hoare, T. et al. Empathy and aggression: two faces of ecstasy? A study of interpretative cognitive bias and mood change in ecstasy users. Psychopharmacology 173, 425–433 (2004). https://doi.org/10.1007/s00213-003-1713-6

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  • DOI: https://doi.org/10.1007/s00213-003-1713-6

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