Skip to main content
Log in

Cordyceps Sinensis-I as an immunosuppressant in heterotopic heart allograft model in rats

  • Published:
Journal of Tongji Medical University Aims and scope Submit manuscript

Summary

To investigate the inhibitory effects of Cordyceps Sinensis-I (CS-1) on the immune response responsible for the organ transplant rejection, we studied its effects of prolonging heterotopic heart allograft survival on rat model with heart graft; the effects of CS-1 were compared with those of cyclosporine A and glucocorticoid, and the possible pathological changes caused by CS-1 were observed. Our results showed that CS-1 can prolong the survival of grafted heart without causing infection, and it did not exert detrimental effects on vital organs. As a result, it proves to be a promising immunosuppressant in clinical organ transplantation in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. One K, et al. Improved technique of heart transplantation in rat. J Thorac Cardiovasc Surg 1969; 57: 225–7.

    Google Scholar 

  2. Lee S, et al. A simplified model for heterotopic rat heart transplantation. Transplantation. 1982; 33: 438–40.

    Article  PubMed  CAS  Google Scholar 

  3. 1983; 10(2): 95–6.

  4. 1984; 9(4): 248–50.

  5. IV. 1988;17(5): 329–31.

  6. V. 1988; 17(5): 332–4.

  7. Mayumi H, et al. Drug-induced tolerance to allografts in mice: V. Prolongation of skin graft survival in tolerant mice with combined immunosuppressive treatments. Transplantation 1985; 39: 335–8.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zheng, Z., Sui-shen, X. Cordyceps Sinensis-I as an immunosuppressant in heterotopic heart allograft model in rats. Journal of Tongji Medical University 10, 100–103 (1990). https://doi.org/10.1007/BF02887870

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02887870

Key words

Navigation