Summary
To investigate the inhibitory effects of Cordyceps Sinensis-I (CS-1) on the immune response responsible for the organ transplant rejection, we studied its effects of prolonging heterotopic heart allograft survival on rat model with heart graft; the effects of CS-1 were compared with those of cyclosporine A and glucocorticoid, and the possible pathological changes caused by CS-1 were observed. Our results showed that CS-1 can prolong the survival of grafted heart without causing infection, and it did not exert detrimental effects on vital organs. As a result, it proves to be a promising immunosuppressant in clinical organ transplantation in the future.
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Zheng, Z., Sui-shen, X. Cordyceps Sinensis-I as an immunosuppressant in heterotopic heart allograft model in rats. Journal of Tongji Medical University 10, 100–103 (1990). https://doi.org/10.1007/BF02887870
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DOI: https://doi.org/10.1007/BF02887870