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The influence of carbenoxolone on steroid-induced ulcer and mucus secretion in the rat

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Abstract

In rats, gastric mucus was decreased by starvation. The administration of carbenoxolone sodium, prednisolone, or their combination to starved rats brought the level of gastric mucus to that of nonstarved controls. Concomitant treatment with carbenoxolone sodium did not prevent prednisolone-induced ulceration of the glandular stomach in starved rats. The ulcerations of the prostomach (squamous epithelium) induced by starvation were prevented by carbenoxolone sodium, prednisolone, or the combination of the two.

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This investigation was supported by Michael Reese Hospital and Medical Center, Medical Research Institute.

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Berg, M., Geisel, A. & Necheles, H. The influence of carbenoxolone on steroid-induced ulcer and mucus secretion in the rat. Digest Dis Sci 20, 134–137 (1975). https://doi.org/10.1007/BF01072339

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