Skip to main content
SpringerLink
Log in

The role of CD15-(Lex)-related carbohydrates in neutrophil adhesion

  • Adhesion Molecules and Their Function
  • Review
  • Published:
The Histochemical Journal Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Albrechtsen, M. &Kerr, M. A. (1989). Characterization of human neutrophil glycoproteins expressing the CD15 differentiation antigen (3-fucosyl-N-acetyllactosamine).Br. J. Haematol. 72, 312–20.

    Google Scholar 

  • Altieri, D. C. &Edgington, T. S. (1988). A monoclonal antibody reacting with distinct adhesion molecules defines a transition in the functional state of the receptor CD11b/CD18 (Mac-1).J. Immunol. 141, 2656–60.

    Google Scholar 

  • Altieri, D. C., Morrissey, J. H. &Edgington, T. S. (1988). Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: an alternative initiation of the coagulation protease cascade.Proc. Natl Acad. Sci. USA 85, 7462–6.

    Google Scholar 

  • Anderson, D. C., Schmalsteig, F. C., Finegold, M. J., Hughes, B. J., Rothlein, R., Miller, L. J., Kohl, S., Tosi, M. F., Jacobs, R. L., Waldrop, T. C., Goldman, A. S., Shearer, W. T. &Springer, T. A. (1985) The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfuntion and clinical features.J. Infect. Dis. 152, 668–89.

    Google Scholar 

  • Anderson, D. C., Miller, L. J., Schmalsteig, F. C., Rothlein, R. &Springer, T. A. (1986) Contributions of the Mac-1 glycoprotein family to adherence dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies.J. Immunol. 137, 15–26.

    Google Scholar 

  • Arfors, K. E., Lundberg, C., Lindborn, L., Lundberg, K., Beatty, P. G. &Harlan, J. M. (1987). A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakagein vivo.Blood 69, 338–40.

    Google Scholar 

  • Arnaout, M. A. (1990) Structure and function of the leucocyte adhesion molecules CD11/CD18.Blood 75, 1037–50.

    Google Scholar 

  • Arnaout, M. A., Hakim, R. M., Todd III, R. F., Dana, N. &Colten, H. R. (1985). Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis.N. Eng. J. Med. 312, 457–62.

    Google Scholar 

  • Aruffo, A., Kolanus, W., Walz, G., Fredman, P. &Seed, B. (1991) CD62/P-selectin recognition of myeloid and tumor cell sulfatides.Cell 67, 35–44.

    Google Scholar 

  • Asada, M., Furukawa, K., Kantor, C., Gahmberg, C. G. &Kobata, A. (1991). Structural study of the sugar chains of human leukocyte cell adhesion molecules CD11/CD18.Biochemistry 30, 1561–71.

    Google Scholar 

  • Audette, M., Buchegger, F., Schreyer, M. &Mach, J. P. (1987) Monoclonal antibody against carcinoembryonic antigen (CEA) identifies two new forms of crosseacting antigens of molecular weight 90,000 and 160,000 in normal granulocytes.Mol. Immunol. 24, 1177–86.

    Google Scholar 

  • Benchimol, S., Fuks, A., Jothy, S., Beauchemin, N., Shirota, K. &Stanners, C. P. (1989). Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule.Cell 57, 327–34.

    Google Scholar 

  • Berg, E. L., Robinson, M. K., Mansson, O., Butcher, E. C. &Magnani, J. L. (1991) A carbohydrate domain common to both sialyl Lea and sialyl Lex is recognised by the endothelial cell leukocyte adhesion molecule ELAM-1.J. Biol. Chem. 266, 14 869–72.

    Google Scholar 

  • Berger, M., O'Shea, J., Cross, A. S., Folks, T. M., Chused, T. M., Brown, E. J. &Frank, M. M. (1984) Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.J. Clin. Invest. 74, 1566–71.

    Google Scholar 

  • Bevilacqua, M. P., Pober, J. S., Mendrick, D. L., Cotran, R. S. &Gimbrone, M. A. (1987) Identification of an inducible endothelial-leucocyte adhesion molecule.Proc. Natl. Acad. Sci. USA 84, 9238–42.

    Google Scholar 

  • Buchegger, F., Schreyer, M., Carrel, S. &Mach, J. P. (1984) Monoclonal antibodies identify a CEA crossreacting antigen of 95 kD (NCA-95) distinct in antigemicity and tissue distribution from the previously described NCA of 55 kDInt. J. Cancer 33, 643–9.

    Google Scholar 

  • Buescher, E. S., McIlheran, S. M., Livesey, S. A., Linner, J. G. &Skubitz K. M. (1989) Human granulocyte CD15 antigens: structural and functional studies. InLeucocyte Typing IV (edited byKnapp, E. et al.) Oxford: Oxford University Press.

    Google Scholar 

  • Bullock, W. E. &Wright, S. D. (1987) Role of the adherencepromoting receptors, CR3, LFA1 and p150,95 in binding ofHistoplasma capsulatum by human macrophages.J. Exp. Med. 165, 195–210.

    Google Scholar 

  • Buyon, J. P., Abramson, S. B., Philips, M. R., Slade, S. G., Ross, G. D., Weissman, G. &Winchester, R. J. (1988) Dissociation between increased surface expression of Gp165/95 and homotypic neutrophil aggregation.J. Immunol. 140, 3156–60.

    Google Scholar 

  • Camerini, D., James, S. P., Stamenkovic, I. &Seed, B. (1989) Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.Nature 342, 78–82.

    Google Scholar 

  • Carlos, T., Kovach, N., Schwartz, B., Rosa, M., Newman, B., Wayner, E., Benjamin, C., Osborn, L., Lobb, R. &Harlan J. (1991) Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1.Blood 77, 2266–71.

    Google Scholar 

  • Chatila, T. A., Geha, R. S. &Arnaout, M. A. (1989) Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.J. Cell. Biol. 109, 3435–44.

    Google Scholar 

  • Collins, T., Williams, A., Johnston, G. I., Kim, J., Eddy, R., Shows, T., Gimbrone, M. A. &Bevilacqua, M. P. (1991)J. Biol. Chem. 266, 2466–73.

    Google Scholar 

  • Corbi, A. L., Miller, L. J., O'Connor, K., Larson, R. S. &Springer, T. A. (1987) cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p. 150–95.EMBO J. 6, 4023–8.

    Google Scholar 

  • Corbi, A. L., Larson, R. S., Kishimoto, T. K., Springer, T. A. &Morton, C. C. (1988) Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.J. Exp. Med. 167, 1597–607.

    Google Scholar 

  • Corral, L., Singer, M. S., Macher, B. A. &Rosen, S. D. (1990) Requirement for sialic acid on neutrophils in a GMP-140 (PADGEM) mediated adhessve interaction with activated platelats.Biochem. Biophys. Res. Commun. 172, 1349–56.

    Google Scholar 

  • Diamond, M. S., Staunton, D. E., Defougerolles, A. R., Stacker, S. A., Garcia-Aguilar, J., Hibbs, M. L. &Springer, T. A. (1990) ICAM-1(CD54): a counter-receptor for Mac-1 (CD11b/CD18).J. Cell. Biol. 111, 3129–39.

    Google Scholar 

  • Dobrina, A., Schwartz, B. R., Carlos, H. D., Ochs, H. D., Beatty, P. G. &Harlan, J. M. (1989) CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM)in vitro.Immunology 67, 502–8.

    Google Scholar 

  • Dobrina, A., Carlos, T. M., Schwartz, B. R., Beatty, P. G., Ochs, H. D. &Harlan, J. M. (1990) Phorbol ester causes downregulation of CD11/CD18-independent neutrophil adherence to endothelium.Immunology 69, 429–34.

    Google Scholar 

  • Dobrina, A., Menegazzi, R., Carlos, T. M., Nardon, E., Cramer, R., Zacchi, T., Harlan, J. M. &Patriarca, P. (1991) Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced endothelial ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 integrin receptor.J. Clin. Invest. 88, 20–6.

    Google Scholar 

  • Dransfield, I. &Hogg, N. (1989) Regulated expression of Mg2+ binding epitope on leukocyte integrin α-subunits.EMBO J. 12, 3759–63.

    Google Scholar 

  • Dustin, M. L. &Springer, T. A. (1989) T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.Nature 341, 619–24.

    Google Scholar 

  • Forsyth, K. D., Simpson, A. C. &Levinsky, R. J. (1989) CD15 antibodies increase neurophil adhesion to endothelium by an LFA-1-dependent mechanism.Eur. J. Immunol. 19, 1331–4.

    Google Scholar 

  • Fritsche, R. &Mach, J. P. (1977) Isolation and characterisation of carcinoembryonic antigen (CEA) extracted from normal human colon mucosa.Immunochem. 14, 129–7.

    Google Scholar 

  • Fukuda, M., Spooncer, E., Oates, J. E., Dell, A. &Klock, J. C. (1984) Structure of sialylated fucosyl lactosaminoglycan isolated from human granulocytes.J. Biol. Chem. 259, 10 925–35.

    Google Scholar 

  • Fukuda, M., Carlsson, S. R., Klock, J. C. &Dell, A. (1986) Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogeneous leukemia cells, and acute myelogenous leukemia cells.J. Biol. Chem. 261, 12 796–804.

    Google Scholar 

  • Geng, J.-G., Bevilacqua, M. P., Moore, K. L., McIntyre, T. M., Prescott, S. M., Kim, J. M., Bliss, G. A., Zimmerman, G. A. &McEver, R. P. (1990) Rapid neutrophil ahdesion to activated endothelium mediated by GMP-140.Nature 343, 757–60.

    Google Scholar 

  • Gooi, H. C., Thorpe, S. J., Hounsell, E. F., Rumpold, H., Kraft, D., Forster, T. &Feizi, T. (1983) Marker of peripheral blood granulocytes and monocytes of man recognized by two monoclonal antibodies. VEP8 and VEP9 involves the trisaccharide 3-fucosyl-N-acetyllactosamine.Eur. J. Immunol. 13, 306–12.

    Google Scholar 

  • Hakkert, B. C., Kuijpers, T. W., Leeuwenberg, J. F. M., van Mourik, J. A. &Roos, D. (1991) Neutrophil and monocyte adherence to an migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4.Blood 78, 2721–6.

    Google Scholar 

  • Hall, P. A. &D'Ardenne, A. J. (1987) Value of CD15 immunostaining in diagnosing Hodgkin's disease: a review of published literature.J. Clin. Pathol. 40, 1298–304.

    Google Scholar 

  • Hamburger, S. A. &McEver, R. P. (1990) GMP-140 mediates adhesion of stimulated platelets to neutrophils.Blood 75, 550–4.

    Google Scholar 

  • Harlan, J. M., Killen, P. D., Senecal, F. M., Schwartz, B. R., Yee, E. K., Taylor, R. F., Beatty, P. G., Price, T. H. &Ochs, H. D. (1985) The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endotheliumin vitro.Blood 66, 167–78.

    Google Scholar 

  • Hermanowski-Vosatka, A., Van Strijp, J. A. G., Swiggard, W. J. &Wright, S. D. (1992) Integrin modulating factor-1: a lipid that alters the function of leukocyte integrins.Cell 68, 341–52.

    Google Scholar 

  • Hession, C., Osborn, L., Goff, D., Chi-Rosso, G., Vassallo, C., Pasek, M., Pittack, C., Tizard, R., Goelz, S., McCarthy, K., Hopple, S. &Lobb, R. (1990)Proc. Natl. Acad. Sci. USA 87, 1673–7.

    Google Scholar 

  • Hibbs, M. L., Jakes, S., Stacker, S. A., Wallace, R. W. &Springer, T. A. (1991) The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1B subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site.J. Exp. Med. 174, 1227–38.

    Google Scholar 

  • Hickstein, D. D., Locksley, R. M., Beatty, P. G., Smith, A., Stone, D. M. &Root, R. K. (1986) Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects.Blood 67, 1054–62.

    Google Scholar 

  • Hildreth, J. E. K., Gotch, F. M., Hildreth, P. D. K. &McMichael, A. J. (1983) A human lymphocyte-associated antigen involved in cell-mediated lympholysis.Eur. J. Immunol. 13, 202–8.

    Google Scholar 

  • Hostetter, R. B., Campbell, D. E., Chi, K., Kerckhoff, S., Cleary, K. R., Ullrich, S., Thomas, P. &Jessup, J. M. (1990) Carcinoembryonic antigen enhances the metastatic potential of human colorectal carcinoma.Arch. Surg. 125, 300–4.

    Google Scholar 

  • Hsu-Lin, S.-C., Berman, C. L., Furie, B. C., August, D. &Furie, B. (1984) A platelet membrane protein expressed during platelet activation and secretion.J. Biol. Chem. 259, 9121–6.

    Google Scholar 

  • Huang, L. C., Civin, C. I., Magnani, J. L., Shaper, J. H. &Ginsburg, V. (1983) My-1 the human myeloid specific antigen detected by mouse monoclonal antibodies, is a sugar sequence found in lacto-N-fucopentaose III.Blood 61, 1020–3.

    Google Scholar 

  • Hynes, R. O. (1987) Integrins: a family of cell surface receptors.Cell 48, 549–54.

    Google Scholar 

  • Hynes, R. O. (1992) Integrins: versatility, modulation and signaling in cell adhesion.Cell 69, 11–25.

    Google Scholar 

  • Imai, Y., Singer, M. S., Fennie, C., Lasky, L. A. &Rosen, S. D. (1991) Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor.J. Cell. Biol. 113, 1213–21.

    Google Scholar 

  • Johnston, G. I., Cook, R. G. &McEver, R. P. (1989) Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation.Cell 56, 1033–44.

    Google Scholar 

  • Jungi, T. W., Spycher, M. O., Nydegger, U. E. &Barandun, S. (1986) Plaletet-leukocyte interactions: Selective binding of thrombin stimulated platelets to human monocytes, polymorphonuclear leukocytes and related cell lines.Blood 67, 629–36.

    Google Scholar 

  • Kerr, M. A. &McCarthy, N. C. (1985) A carbohydrate differentiation antigen of granulocytes, brain and many tumours.Biochem. Soc. Trans. 13, 424–6.

    Google Scholar 

  • Kishimoto, T. K., Jutila, M. A., Berg, E. L. &Butcher, E. C. (1989a) Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors.Science 245, 1238–41.

    Google Scholar 

  • Kishimoto, T. K., Larson, R. S., Corbi, A. L., Dustin, M. L., Staunton, D. E. &Springer, T. A. (1989b) The leukocyte integrins: LFA1, Mac-1 & p150,95.Adv. Immunol. 46, 149–82.

    Google Scholar 

  • Kishimoto, T. K., Warnock, R. A., Jutila, M. A., Butcher, E. C., Lane, C., Anderson, D. C. &Smith, C. W. (1991) Antibodies against human neutrophil LECAM-1 (LALM-1/Leu8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathwayin vitro.Blood 78, 805–11.

    Google Scholar 

  • Klein, L. M., Lavker, R. M., Matis, W. L. &Murphy, G. F. (1989) Degtanulation of human mast cells induces an endothelial antigen central to leukocyte adhesion.Proc. Natl. Acad. Sci. USA 86, 8972–6.

    Google Scholar 

  • Kniep, B. & Mühlradt, P. F. (1987) Monoclonal antibodies of the myeloid panel recognizing glycospingolipids. InLeucocyte Typing III: White Cell Differentation Antigens. (edited byA. J. McMichael) pp. 619–21.

  • Kniep, B., Peter-Katalinic, J. &Muhlradt, P. F. (1989) Glycosphingolipid-recognizing antibodies of the myeloid section. InLeucocyte Typing IV (edited byKnapp, W., et al.). Oxford: Oxford University Press.

    Google Scholar 

  • Kohl, S., Springer, T. A., Schmalstieg, F. C., Loo, L. S. &Anderson, D. C. (1984) Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency.J. Immunol. 133, 2972–8.

    Google Scholar 

  • Koopman, G., Van Kooyk, Y., De Graffe, M., Meyer, C. J. L. M., Figdor, C. J. &Pals, S. T. (1990). Triggering of the CD44 antigen on T lymphocyte promotes T cell adhesion through the LFA-1 pathway.J. Immunol. 145, 3589–93.

    Google Scholar 

  • Kuijpers, T. W., Hakkert, B. C., Hoogerwerf, M., Leeuwenberg, J. F. M. &Roos, D. (1991) Role of endothelial leukocyte adhesion molecule-1 and platelet activating factor in neutrophil adherence to IL-1 pre-stimulated endothelial cells: Endothelial leukocyte adhesion molecule-1-mediated CD18 activation.J. Immunol. 147, 1369–76.

    Google Scholar 

  • Kuroki, M., Matsuo, Y. &Matsuoka, Y. (1990) Nonspecific cross-reacting antigen (NCA) expressed by human granulocytes: six species with different peptide sizes and membrane anchoring forms.Biochem. Biophys. Res. Commun. 166, 701–8.

    Google Scholar 

  • Kürzinger, K., Ho, M. K. &Springer, T. A. (1982) Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell mediated killing.Nature 296, 668–70.

    Google Scholar 

  • Kyan-Aung, U., Haskard, D. O., Poston, R. N., Thornhill, M. H. &Lee, T. H. (1991) Endothelial leukocyte adhesion molecule-1 and intercellular adhesion molecule-1 mediate the adhesion of eosinophils to endothelial cellsin vitro and are expressed by endothelium in allergic cutaneous inflammationin vivo.J. Immunol. 146, 521–8.

    Google Scholar 

  • Larsen, E., Celi, A., Gilbert, G. E., Furie, B. C., Erban, J. K., Bonfanti, R., Wagner, D. D. &Furie, B. (1989) PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes.Cell 59, 305–12.

    Google Scholar 

  • Larsen, E., Palabrica, T., Sajer, S., Gilbert, G. E., Wagner, D. D., Furie, B. C. &Furie, B. (1990) PADGEM-Dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15).Cell 64, 467–74.

    Google Scholar 

  • Larson, R. S., Corbi, A. L., Berman, L. &Springer, T. A. (1989) Primary structure of the LFA-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.J. Cell. Biol. 108, 703–12.

    Google Scholar 

  • Lawrence, M. B. &Springer, T. A. (1991) Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.Cell 65, 859–73.

    Google Scholar 

  • Leusch, H. G., Hefta, S. A., Drzeniek, Z., Hummel, K., Markospusztai, Z. &Wagener, C. (1990)Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific cross-reacting antigen (NCA).FEBS Lett 261, 405–9.

    Google Scholar 

  • Lewinsohn, D. M., Bargatze, R. F. &Butcher, E. C. (1987) Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.J. Immunol. 138, 4313–21.

    Google Scholar 

  • Lo, S. K., Detmers, P. A., Levin, S. M. &Wright, S. D. (1989a) Transient adhesion of neutrophils to endothelium.J. Exp. Med. 169, 1779–93.

    Google Scholar 

  • Lo, S. K., Lee, S., Ramos, R. A., Lobb, R., Rosa, M., Chi.-Rosso, G. &Wright, S. D. (1991) Endothelial leukocyte adhesion molecule-1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, mac-1, amb2) on human neutrophils.J. Exp. Med. 173, 1493–500.

    Google Scholar 

  • Lo, S. K., Van Seventer, G. A., Levin, S. M. &Wright, S. D. (1989b) Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands.J. Immunol. 143, 3325–9.

    Google Scholar 

  • Lopez, A. F., Williamson, J., Gamble, J. R., Begley, C. G., Harlan, J. M., Klebanoff, S. J., Waltersdorph, A., Wong, G., Clark, S. C. &Vadas, M. A. (1986) Recombinant human granulocyte-macrophage colony-stimulating factor stimulatesin vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.J. Clin. Invest. 78, 1220–8.

    Google Scholar 

  • Lorant, D. E., Patel, K. D., McIntyre, T. M., McEver, R. P., Prescott, S. M. &Zimmerman, G. A. (1991). Coexpression of GMP-140 and PAV by endothelium stimulated by histamine or thrombine: a juxtacrine system for adhesion and activation of neutrophils.J. Cell. Biol. 115, 223–34.

    Google Scholar 

  • Lowe, J. B., Stoolman, L. M., Nair, R. P., Larsen, R. D., Behrend, T. L. &Marks, R. M. (1991). A transfected human fucosyl-transferase cDNA determines biosynthesis of oligosaccharide ligand(s) for endothelial leukocyte adhesion molecule 1.Biochem. Soc. Trans. 19, 649–53.

    Google Scholar 

  • Lundberg, C. &Wright, S. D. (1990) Relation of the CD11/CD18 family of leukocyte antigens to the transient neutropenia caused by chemoattractants.Blood.76, 1240–5.

    Google Scholar 

  • Marks, R. M., Todd, R. F. &Ward, P. A. (1989) Rapid induction of neutrophil-endothelial adhesion by endothelial complement fixation.Nature 339, 314–7.

    Google Scholar 

  • McCarthy, N. C., Simpson, J. R., Coghill, G. &Kerr, M. A. (1985) Expression in normal adult, fetal and neoplastic tissues of a carbohydrate differentiation antigen recognised by antigranulocyte mouse monoclonal antibodies.J. Clin. Pathol. 38, 521–9.

    Google Scholar 

  • McEver, R. P. &Martin, M. N. (1984). A monoclonal antibody to a membrane glycoprotein binds only to activated platelets.J. Biol. Chem. 259, 9799–804.

    Google Scholar 

  • McEver, R. P., Beckstead, J. H., Moore, K. L., Marshall-Carison, L. &Bainton, D. F. (1989). GMP-140, a platelet a-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.J. Clin. Invest. 84, 92–9.

    Google Scholar 

  • Melnick, D. A., Nauseef, W. M., Markowitz, S. D., Gardner, J. P. &Malech, H. L. (1985) Biochemical analysis and subcellular localization of a neutrophil-specific antigen, PMN-7, involved in the respiratory burst.J. Immunol. 134, 3346–55.

    Google Scholar 

  • Melnick, D. A., Meshulam, T., Manto, A. &Malech, H. L. (1986) Activation of human neutrophils by monoclonal antibody PMN7C3: cell movement and adhesion can be triggered independently from the respiratory burst.Blood 5, 1388–94.

    Google Scholar 

  • Merrill, J. T., Slade, S. G., Weissmann, G., Winchester, R. &Buyon, J. P. (1990) Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C dependent phosphorylation.J. Immunol. 145, 2608–15.

    Google Scholar 

  • Micklem, K. J. &Sim, R. B. (1985) Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography.Biochem. J. 231, 233–6.

    Google Scholar 

  • Miedema, F., Tetteroo, P. A. T., Hesselink, W. G., Werner, G., Spits, H. &Melief, C. J. M. (1984). Both Fc receptors and LFA1 on human T lymphocytes are required for antibody-dependent cellular cytotoxicity (K cell activity).Eur. J. Immunol. 14, 518–23.

    Google Scholar 

  • Miller, L. J., Schwarting, R. &Springer, T. A. (1986). Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation.J. Immunol. 137, 2891–900.

    Google Scholar 

  • Miller, L. J., Wiebe, M. &Springer, T. A. (1987). Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins.J. Immunol. 138, 2381–3.

    Google Scholar 

  • Miura, M., Fukuyama, Y., Hirano, M., Matsuzaki, H. &Oka, H. (1990). Sugar-chain multiformity of human carcinoembryonic antigen: difference between normal and tumor-associated subfractions.Clin. Chem. 35, 583–4.

    Google Scholar 

  • Montgomery, K. F., Osborn, L., Hession, C., Tizard, R., Goff, D., Vassallo, C., Tarr, P. I., Bomsztyk, K., Lobb, R., Harlan, J. M. &Pohlman, T. H. (1991) Activation of endothelialleukocyte adhesion molecule I (ELAM-1) gene transcription.Proc. Natl Acad. Sci. USA 88, 6523–7.

    Google Scholar 

  • Moore, K. L., Varki, A. &McEver, R.P. (1991) GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like interaction.J. Cell Biol. 112, 491–9.

    Google Scholar 

  • Mosser, D. M. &Edelson, P. J. (1985) The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis ofLeishmania promastigotes.J. Immunol. 135, 2785–9.

    Google Scholar 

  • Munro, M. J., Pober, J. S. &Cotran, R. S. (1991). Brief communication. Recruitment of neutrophils in the local endotoxin response: association withde novo endothelial expression of endothelial leukocyte adhesion molecule-I.Lab. Invest. 64, 295–9.

    Google Scholar 

  • Myones, B. L., Dalzell, J. G., Hogg, N. &Ross, D. G. (1988) Neutrophil and monocyte cell surface p150/95 has iC3b-receptor (CR4) activity resembling CR3.J. Clin. Invest. 82, 640–51.

    Google Scholar 

  • Nauseef, W. M., Root, R. K., Newman, S. L. &Malech, H. L. (1983). Inhibition of zymosan activation of human neutrophil oxidative metabolism by a mouse monoclonal antibody.Blood 62, 635–44.

    Google Scholar 

  • Nourshargh, S., Rampart, M., Hellwell, P. G., Jose, P. J., Harlan, J. M., Edwards, A. J. &Williams, T. J. (1989). Accumulation of111In-neutrophils in rabbit skin in allergic and nonallergic inflammatory reactionsin vivo. Inhibition by neutrophil pretreatmentin vitro with a monoclonal antibody recognising the CD18 antigen.J. Immunol. 142, 3193–9.

    Google Scholar 

  • Oikawa, S., Inuzuka, C., Kuroki, M., Matsuoka, Y., Kosaki, G. &Nakazato, H. (1989). Cell adhesion activity of nonspecific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion.Biochem. Biophys. Res. Commun. 164, 39–45.

    Google Scholar 

  • O'Shea, J. J., Brown, E. J., Seligmann, B. E., Metcalf, J. A., Frank, M. M. &Gallin, J. I. (1985). Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.J. Immunol. 134, 2580–7.

    Google Scholar 

  • Patarroyo, M., Beatty, P. G., Fabre, J. W. &Gahmberg, C. G. (1985) Identification of a cell surface protein complex mediating phorbol ester-induced adhesion (binding among human mononuclear leucocytes).Scand. J. Immunol. 22, 171–5.

    Google Scholar 

  • Patarroyo, M., Prieto, J., Rincon, J., Timonen, T., Lunberg, C. Lindbom, L., Asjo, B. &Gahmberg, C. G. (1990). Leukocytecell adhesion: a molecular process fundamental in leukocyte physiology.Immunol. Rev. 114, 67–108.

    Google Scholar 

  • Patel, K. D., Zimmerman, G. A., Prescott, S. M., McEver, R. P. &McIntyre, T. M. (1991) Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils.J. Cell. Biol. 112, 749–59.

    Google Scholar 

  • Philips, M. R., Buyon, J. P., Winchester, R., Weissman, G. &Abramson, S. B. (1988) Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation.J. Clin. Invest. 82, 495–501.

    Google Scholar 

  • Phillips, M. L., Nudelman, E., Gaeta, F. C. A., Perez, M., Singhal, A. K., Hakomori, S.-I. &Paulson, J. C. (1990). ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, Sialyl-Lex.Science 250, 1130–2.

    Google Scholar 

  • Picker, L. J., Warnock, R. A., Burns, A. R., Doerschuk, C. M., Berg, E. L. &Butcher, E. C. (1991) The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140.Cell 66, 921–33.

    Google Scholar 

  • Polley, M. J., Phillips, M. L., Wayner, E. &Nudelman, E. (1991) CD62 and endothelial cell-leukocyte adhesion molecule I (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x.Proc. Natl Acad. Sci. USA 88, 6224–8.

    Google Scholar 

  • Pytowski, B., Easton, T. G., Valinsky, J. E., Calderon, T., Sun, T. &Christman, J. (1988). A monoclonal antibody to a human neutrophil-specific plasma membrane antigen.J. Exp. Med. 167, 421–39.

    Google Scholar 

  • Rice, G. E. &Bevilacqua, M. P. (1989). An inducible endothelial cell surface glycoprotein mediates melanoma adhesion.Science 246, 1303–6.

    Google Scholar 

  • Rothlein, R., Dustin, M. L., Marlin, S. D. &Springer, T. A. (1986) A human intercellular adhesion molecule (1CAM-1) distinct from LFA-1.J. Immunol. 137, 1270–4.

    Google Scholar 

  • Sanchez-Madrid, F., Krensky, A. M., Ware, C. F., Robbins, E., Strominger, J. L., Burakoff, S. J. &Springer, T. A. (1982). Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2 and LFA-3.Proc. Natl Acad. Sci. USA 79, 7489–93.

    Google Scholar 

  • Sanchez-Madrid, F., Nagy, J., Robbins, E., Simon, P. &Springer, T. A. (1983). A human luukocyte differentiation antigen family with distinct alpha subunits and a common beta subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement reactor (OKM1/Mac-1), and the p150-95 molecule.J. Exp. Med. 158, 1785–803.

    Google Scholar 

  • Sanders, D. S. A., Kerr, M. A., Hopwood, D., Coghill, G. &Milne, G. A. (1988) Expression of the 3-fucosylN-acetyllactosamine (CD 15) antigen in normal, metaplastic, dysplastic, and neoplastic squamous epithelia.J. Pathol. 154, 255–62.

    Google Scholar 

  • Sanders, D. S. A., Stocks, S. C., Milne, D. M., Milne, G. A., Hopwood, D. & Kerr, M. A. (1992) Membranous expression of carcinoembryonic antigen (CEA) in the normal cervical squamous mucosa.J. Pathol. (in press).

  • Santamaria, M., Llamas, L., Ree, H. J., Sheibani, K., Ho, Y., Su, I. &Hsu, S. (1988) Expression of sialylated leu-M1 antigen, in histiocytosis X.Am. J. Clin. Pathol. 89, 211–6.

    Google Scholar 

  • Schleiffenbaum, B., Moser, R., Patarroyo, M. &Fehr, J. (1989) The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression.J. Immunol. 142, 3537–45.

    Google Scholar 

  • Schwarting, R. R., Stein, H. &Yi Wang, C. (1985) The monoclonal antibodies S-HCL1 (Leu-14) and S-HCL3 (Leu-M5) allow diagnosis of hairy cell leukemia.Blood 65, 974–80.

    Google Scholar 

  • Singer, I. I., Scott, S., Kawka, D. W. &Kazazis, D. M. (1989) Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes.J. Cell. Biol. 109, 3169–82.

    Google Scholar 

  • Skinner, M. P., Lucas, C. M., Burns, G. F., Chesterman, C. N. &Berndt, M. C. (1991). GMP-140 binding to neutrophils is inhibited by sulfated glycans.J. Biol. Chem. 266, 5371–4.

    Google Scholar 

  • Skubitz, K. M. &Snook, R. W. (1987). Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMAC-1/Gp150/95) and CR1 on human neutrophils.J. Immunol. 139, 1631–9.

    Google Scholar 

  • Skubitz, K. M., Pessano, S., Bottero, L., Ferrerro, D., Rovera, G. &August, J. T. (1983). Human granulocyte surface molecules identified by murine monoclonal antibodies.J. Immunol. 131, 1882–8.

    Google Scholar 

  • Skubitz, K., Balke, J., Ball, E., Bridges, R., Buescher, E. S., Campos, L., Harvath, L., Kerr, M., Kniep, B., Spitalnik, P., Skubitz, A., Thompson, A., Wick, M. &Williams, L. (1989) Report on the CD15 cluster workshop. InLeucocyte Typing IV (edited byKnapp, W. et al.) Oxford: Oxford University Press.

    Google Scholar 

  • Skubitz, K. M., Ducker, T. P. &Gouell, S. A. (1992) CD66 monoclonal antibodies recognize a phosphotyrosine-containing protein bearing a carcinoemblyonic antigen crossreacting antigen on the surface of human neutrophils.J. Immunol. 148, 852–60.

    Google Scholar 

  • Smith, C. W., Marlin, S. D., Rothlein, R., Toman, C. &Anderson, D. C. (1989). Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.J. Clin. Invest. 83, 2008–17.

    Google Scholar 

  • Spooncer, E., Eukuda, M., Klock, J. C., Oates, J. E. &Dell, A. (1984) Isolation and characterization of polyfucosylated lactosaminoglycan from human granulocytes.J. Biol. Chem. 259, 4792–801.

    Google Scholar 

  • Springer, T. A. &Lasky, L. A. (1991) Sticky sugars for selectins.Nature 349, 196–7.

    Google Scholar 

  • Springer, T. A., Thompson, W. S., Miller, L. J., Schmalstieg, F. C. &Anderson, D. C. (1984) Inherited deficiency of the Mac-1, LFA1, p150,95 glycoprotein family and its molecular basis.J. Exp. Med. 160, 1901–18.

    Google Scholar 

  • Springer, T. A., Miller, L. J. &Anderson, D. C. (1986) p150,95, the third member of the Mac-1, LFA-1 human leukocyte adhesion glycoprotein family.J. Immunol. 136, 240–5.

    Google Scholar 

  • Stacker, S. A. &Springer, T. A. (1991) Leukocyte integrin P150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium.J. Immunol. 146, 648–55.

    Google Scholar 

  • Staunton, D. E., Dustin, M. L. &Springer, T. A. (1989) Functional cloning of ICAM-2 a cell-adhesion ligand for LFA-1 homologous to ICAM-1.Nature 339, 61–4.

    Google Scholar 

  • Stocks, S. C. &Kerr, M. A. (1991) The effect on neutrophil adhesion of antibodies against surface glycoproteins which express CD15 (3-fucosyl-N-acetyllactosamine).Glycoconj. J. 8, 226.

    Google Scholar 

  • Stocks, S. C., Albrechtsen, M. &Kerr, M. A. (1990) Expression of the CD15 differentiation antigen (3-fucosyl-N-acetyllactosamine, Lex) on putative neutrophil adhesion molecules CR3 and NCA-160.Biochem. J. 268, 275–85.

    Google Scholar 

  • Stoolman, L. M. (1989). Adhesion molecules controlling lymphocyte migration.Cell 56, 907–10.

    Google Scholar 

  • Symington, F. W., Hedges, D. L. &Hakamori, S.-I. (1985). Glycolipid antigens of human polymorphonuclear neutrophils and the inducible HL-60 myeloid leukemia line.J. Immunol. 134, 2496–506.

    Google Scholar 

  • Te Velde, A. A., Keizer, G. D. &Figdor, C. G. (1987) Differential function of LFA-1 family molecules (CD11 and CD18) in adhesion of human monocytes to melanoma and endothelial cells.Immunology 61, 261–7.

    Google Scholar 

  • Tedder, T. F., Isaacs, G. M., Ernst, T. J., Demetri, G. D., Adler, D. A. &Disteche, C. M. (1989) Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1: homology with the mouse lymphocyte homing receptor and other human adhesion proteins.J. Exp. Med. 170, 123–33.

    Google Scholar 

  • Tetteroo, P. A. T., Mulder, A., Lanodorp, P. M., Zola, H., Baker, D. A., Visser, F. J. &von dem Borne, A. E. G. K. (1984) Myeloid-associated antigen, 3-α-fucosyl-N-acetyllactosamine (FAL) location on various granulocyte membrane glycoproteins and masking upon monocytic differentiation.Eur. J. Immunol. 14, 1089–95.

    Google Scholar 

  • Thompson, J. &Zimmerman, W. (1988)The carcinoembryonic antigen gene family: structure, expression and evolution.PitTumor Biol. 9, 63–83.

    Google Scholar 

  • Tiemeyer, M., Swiedler, S. J., Ishihara, M. Moreland, M., Schweingruber, H., Hirtzer, P. &Brandley, B. K. (1991) Carbohydrate ligands for endothelial-leukocyte adhesion molecule 1.Proc. Natl Acad. Sci. USA 88, 1138–42.

    Google Scholar 

  • Todd, R. F., III, Nadler, L. M. &Schlossman, S. F. (1981) Antigens on human monocytes identified by monoclonal antibodies.J. Immunol. 126, 1435–42.

    Google Scholar 

  • Todd, R. F., Arnaout, M. A., Rosin, R. E., Crowley, C. A., Peters, W. A. &Babior, B. M. (1984) Subcellular localization of the large subunit of Mo1 (Mo1a; formerly gp110), a surface glycoprotein associated with neutrophil adhesion.J. Clin. Invest. 74, 1280–90.

    Google Scholar 

  • Trowbridge, I. S. &Omary, M. B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.J. Exp. Med. 154, 1517–24.

    Google Scholar 

  • Tyrrell, D., James, P., Rao, N., Foxall, C., Abbas, S., Dasgupta, F., Nashed, M., Hasegawa, A., Kiso, M., Asa, D., Kidd, J. &Brandley, B. K. (1991) Structural requirements for the carbohydrate ligand of E-selectin.Proc. Natl Acad. Sci. USA 88, 10 372–6.

    Google Scholar 

  • Uciechowski, P. &Schmidt, R. E. (1989) Cluster report: CD11. InLeucocyte Typing IV (edited byKnapp, W. et al). Oxford: Oxford University Press.

    Google Scholar 

  • Valmu, L., Autero, M., Siljander, P., Patarroyo, M. &Gahmberg, C. G. (1991) Phosphorylation of the B-subunit of CD11/CD18 integrins by protein kinase C correlates with leukocyte adhesion.Eur. J. Immunol. 21, 2857–62.

    Google Scholar 

  • Vedder, N. B. &Harlan, J. M. (1988) Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.J. Clin. Invest. 81, 676–82.

    Google Scholar 

  • Vercellotti, G. M., Platt, J. L., Bach, F. H. &Dalmasso, A. P. (1991) Neutrophil adhesion to xenogeneic endothelium via iC3b.J. Immunol. 146, 730–4.

    Google Scholar 

  • Von Andrian, U. H., Chambers, J. D., Mcevoy, L. M., Bargatze, R. F., Arfors, K. E. &Butcher, E. C. (1991) Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta2 integrinsin vivo.Proc. Natl Acad. Sci. USA 88, 7538–42.

    Google Scholar 

  • Wallis, W. J., Hickstein, D. D., Schwartz, B. R., June, C. H., Ochs, H. D., Beatty, P. G., Klebanoff, S. J. &Harlan, J. M. (1986) Monoclonal antibody-defined functional epitopes on the adhesion-promoting glycoprotein complex (CDw18) of human neutrophils.Blood 67, 1007–13.

    Google Scholar 

  • Walz, G., Aruffo, A., Kolanus, W., Bevilacqua, M. &Seed, B. (1990) Recognition by ELAM-1 of the Sialyl-Lex determinant on myeloid and tumor cells.Science 250, 1132–5.

    Google Scholar 

  • Weller, P. F., Rand, T. H., Goelz, S. E., Chi-Rosso, G. &Lobb, R. R. (1991) Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.Proc. Natl. Acad. Sci. USA 88, 7430–3.

    Google Scholar 

  • Wong, C. S., Gamble, J. R., Skinner, M. P., Lucas, C. M., Berndt, M. C. &Vadas, M. A. (1991) Adhesion protein GMP140 inhibits superoxide anion release by human neutrophilsProc. Natl. Acad. Sci. USA 88, 2397–401.

    Google Scholar 

  • Wright, S. D. &Jong, M. T. C. (1986) Adhesion-promoting receptors on human macrophages recogniseEscherichia coli by binding to lipopolysaccharide.J. Exp. Med. 164, 1876–88.

    Google Scholar 

  • Wright, S. D. &Meyer, B. C. (1986) Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes.J. Immunol. 136, 1759–64.

    Google Scholar 

  • Wright, S. D., Weitz, J. I., Huang, A. J., Levin, S. M., Silverstein, S. C. &Loike, J. D. (1988) Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen.Proc. Natl Acad. Sci. USA 85, 7734–8.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Dundee, Ninewells Hospital Medical School, DD1 9SY, Dundee, UK

    Michael A. Kerr & S. Craig Stocks

Authors
  1. Michael A. Kerr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Craig Stocks
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kerr, M.A., Craig Stocks, S. The role of CD15-(Lex)-related carbohydrates in neutrophil adhesion. Histochem J 24, 811–826 (1992). https://doi.org/10.1007/BF01046353

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01046353

Keywords

Search

Navigation