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Meningitis due toBorrelia burgdorferi in the initial stage of Lyme disease

  • Infectious Diseases
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Abstract

Borrelia burgdorferi (B. b.) was isolated from cerebrospinal fluid from two children with aseptic meningitis. Serology forB. b. was initially negative or borderline and became positive during the subsequent course. Children with aseptic meningitis of unknown origin should be re-evaluated within 1 month to detect possible increasing antibody titres toB. b. Aseptic meningitis may be a stage 1 manifestation of Lyme disease.

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Abbreviations

B. b. :

Borrelia burgdorferi

CSF:

cerebrospinal fluid

CNS:

central nervous system

ESR:

erythrocyte sedimentation rate

IFA:

immunofluorscence assay

References

  1. Ackermann R, Kabatzki J, Boisten HP, Steere AC, Grodzicki RC, Hartung S, Runne U (1984) Spirochäten-Ätiologie der Erythema-chronicum-migrans-Krankheit. Dtsch Med Wochenschr 109:92–97

    Google Scholar 

  2. Barbour AG (1984) Isolation and cultivation of Lyme disease spirochetes. In: Steere AC, Malawista SE, Craft JE, Fischer DK, García-Blanco M (eds) Lyme disease — First international symposium, The Yale Journal of Biology and Medicine, New Haven, pp 71–76

  3. Barbour AG, Schrumpf ME (1986) Polymorphism of major surface proteins ofBorrelia burgdorferi. Zentralbl Bakteriol Midrobiol Hyg [A] 263:83–91

    Google Scholar 

  4. Barbour AG, Tessier SL, Todd WJ (1983) Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody. Infect Immunol 41:795–804

    Google Scholar 

  5. Craft JE, Grodzicki RL, Steere AC (1984) Antibody response in Lyme disease: evaluation of diagnostic tests. J Infect Dis 149: 789–795

    Google Scholar 

  6. Cutler JC, Bauer TJ, Price EV, Schwimmer BH (1954) Comparison of spinal fluid findings among syphilitic and nonsyphilitic individuals. Am J Syphilis 38:447–458

    Google Scholar 

  7. Hopf HC, Stroux B (1968) Die geographische Verteilung der Akrodermatitis chronica atrophicans (Herxheimer) in der Umgebung von Würzburg. Z Hautkr Geschlkr 43:41–48

    Google Scholar 

  8. Hyde FW, Johnson RC (1984) Genetic relationship of Lyme disease spirochetes toBorrelia, Treponema, andLeptospira spp. J Clin Microbiol 20:151–154

    Google Scholar 

  9. Kristoferitsch W, Baumhackl U, Sluga E, Stanek G, Zeiler K (1986) High-dose penicillin therapy in meningopolyneuritis Garin-Bujadoux-Bannwarth. Zentralbl Bakteriol Mikrobiol Hyg [A] 263:357–364

    Google Scholar 

  10. Magnarelli LA, Anderson JF, Johnson RC (1987) Cross-reactivity in serological tests for Lyme disease and other spirochetal infections. J Infect Dis 156:183–188

    Google Scholar 

  11. Meissner HC, Gellis SE, Milliken JF (1982) Lyme disease first observed to be aseptic meningitis. Am J Dis Child 136:465–467

    Google Scholar 

  12. Park KH, Jones BE, Barbour AG (1986) Erythema chronicum migrans of Lyme disease: diagnosis by monoclonal antibodies. J Am Acad Dermatol 15:406–410

    Google Scholar 

  13. Reik L, Burgdorfer W, Donaldson JO (1986) Neurologic abnormalities in Lyme disease without erythema chronicum migrans. Am J Med 81:73–78

    Google Scholar 

  14. Russel H, Sampson JS, Schmid GP, Wilkinson HW, Plikaytis B (1984) Enzyme-linked immunosorbent assay and indirect immunofluorescence assay for Lyme disease. J Infect Dis 149:465–470

    Google Scholar 

  15. Schmedding E, Verboven M, Lauwers S, Ebinger G, Rom N, Loeb H (1986) Lymphocytic meningoradiculitis (Garin-Bujadoux Bannwarth): from syndrome to disease? Eur J Pediatr 144:497–502

    Google Scholar 

  16. Steere AC, Gibofsky A, Patarroyo ME, Winchester RJ, Hardin JA, Malawista SE (1979) Chronic Lyme arthritis: clinical and immunogenetic differentiation from rheumatoid arthritis. Ann Intern Med 90:896–901

    Google Scholar 

  17. Steere AC, Hardin JA, Ruddy S, Mummaw JG, Malawista SE (1979) Lyme arthritis: correlation of serum and cryoglobulin IgM with activity, and serum IgG with remission. Arthritis Rheum 22: 471–483

    Google Scholar 

  18. Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahm DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE (1983) The early clinical manifestations of Lyme disease. Ann Intern Med 99:76–82

    Google Scholar 

  19. Steere AC, Grodzicki RL, Kornblatt AN, Craft JE, Barbour AG, Burgdorfer W, Schmid GP, Johnson E, Malawista SE (1983) The spirochetal etiology of Lyme disease. N Engl J Med 308:733–740

    Google Scholar 

  20. Steere AC, Pachner AR, Malawista SE (1983) Neurologic abnormalities of Lyme disease: successful treatment with high-dose intravenous penicillin. Ann Intern Med 99:767–772

    Google Scholar 

  21. Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Pachner AR, Rahn DW, Sigal LH, Taylor E, Malawista SE (1986) Clinical manifestations of Lyme disease. Zentralbl Bakteriol Mikrobiol Hyg [A] 263:201–208

    Google Scholar 

  22. Stiernstedt GT, Granström M, Hederstedt B, Sköldenberg B (1985) Diagnosis of spirochetal meningitis by enzyme-linked immunosorbent assay and indirect immunofluorescence assay in serum and cerebrospinal fluid. J Clin Microbiol 21:819–825

    Google Scholar 

  23. Weder B, Wiedersheim P, Matter L, Steck A, Otto F (1987) Chronic progressive neurological involvement inBorrelia burgdorferi infection. J Neurol 234:40–43

    Google Scholar 

  24. Wildin S, Chonmaitree T (1987) The importance of the virology laboratory in the diagnosis and management of viral meningitis. Am J Dis Child 141:454–457

    Google Scholar 

  25. Wilske B, Preac-Mursic V, Schierz G, Busch KV (1986) Immunochemical and immunological analysis of EuropeanBorrelia burgdorferi strains. Zentralbl Bakteriol Mikrobiol Hyg [A] 263:92–102

    Google Scholar 

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Huppertz, H.I., Sticht-Groh, V. Meningitis due toBorrelia burgdorferi in the initial stage of Lyme disease. Eur J Pediatr 148, 428–430 (1989). https://doi.org/10.1007/BF00595904

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  • DOI: https://doi.org/10.1007/BF00595904

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