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Cutaneous responses to topical methyl nicotinate in black, oriental, and caucasian subjects

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Summary

The response of human skin to topical methyl nicotinate (MN) has been monitored in black, oriental, and caucasian subjects. The study aimed to address the question: “Do racial differences in percutaneous absorption and microcirculatory sensitivity exist?” MN-induced vasodilation was assessed visually and by laser Doppler velocimetry (LDV). At three dose levels, in the three subject populations, four parameters were compared: (a) the diameter of the maximum visually perceptible erythematous area (Emx); (b) the area under the erythematous diameter versus time curve (AUE); (c) the maximum LDV response (Lmx); and (d) the area under the LDV response versus time curve (AUL). At p<0.05, AUL (black)>AUL (caucasian) for all MN concentrations; AUL (oriental)>AUL (caucasian) for the higher dose levels. Emx, AUE and Lmx showed no significant differences between races within concentrations. For all subjects, Emx AUE, and AUL were significantly dependent on MN dose whereas Lmx was not. The results suggest that some racial differences in response to topical MN exist and that perception of these distinctions may depend upon the method of measurement.

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Author notes

  1. C. J. Gean

    Present address: School of Medicine, University of Maryland, Baltimore, MD, USA

  2. E. Tur

    Present address: Department of Dermatology, Ichilov Hospital, Tel Aviv, Israel

Authors and Affiliations

  1. Department of Pharmacy, Schoos of Pharmacy and Mdicine, University of California, San Francisco, 94143, San Francisco, CA, USA

    C. J. Gean, E. Tur, H. I. Maibach & R. H. Guy

  2. Department of Pharmaceutical Chemistry, Schoos of Pharmacy and Mdicine, University of California, San Francisco, 94143, San Francisco, CA, USA

    C. J. Gean, E. Tur, H. I. Maibach & R. H. Guy

  3. Department of Dermatology, Schoos of Pharmacy and Mdicine, University of California, San Francisco, 94143, San Francisco, CA, USA

    C. J. Gean, E. Tur, H. I. Maibach & R. H. Guy

Authors
  1. C. J. Gean
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  2. E. Tur
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  3. H. I. Maibach
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  4. R. H. Guy
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Gean, C.J., Tur, E., Maibach, H.I. et al. Cutaneous responses to topical methyl nicotinate in black, oriental, and caucasian subjects. Arch Dermatol Res 281, 95–98 (1989). https://doi.org/10.1007/BF00426585

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  • DOI: https://doi.org/10.1007/BF00426585

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