Summary
The purpose of the present investigation was to examine the comparative interaction effects of amphetamine, alpha-pipradrol, methylphenidate and thozalinone with imipramine or desmethylimipramine.
Three distinct activity profiles were obtained in a nondiscriminated avoidance schedule. Amphetamine facilitation was both enhanced and prolonged by the addition of the imipramines. Alpha-pipradrol and methylphenidate produced similar profiles of transitory enhancement, without prolongation of activity beyond that of the excitant alone. The combination of thozalinone and the imipramines produced neither enhancement, nor prolongation, of the facilitatory effects of thozalinone.
The only distinction between the interaction effects of imipramine and desmethylimipramine was one of relative potency.
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References
Axelrod, J.: Studies on sympathomimetic amines. II. The biotransformation and physiological disposition of d-amphetamine, d-p-hydroxy-amphetamine and d-methamphetamine. J. Pharmacol. exp. Ther. 110, 315–326 (1954).
Bernstein, B., and L. P. Cancro: The effect of two temporal variables of avoidance conditioning on drug behavior interaction. Psychopharmacologia (Berl.) 3, 105–113 (1962).
Carlton, P. L.: Potentiation of the behavioral effects of amphetamine by imipramine. Psychopharmacologia (Berl.) 2, 364–367 (1961).
Dews, P. B.: Drugs affecting behavior. In V. A. Drill (Ed.): Pharmacology in Medicine. New York: McGraw-Hill 1958.
Ellison, T., L. Gutzart, and E. J. Van Loon: The comparative metabolism of d-Amphetamine-C14 in the rat, dog and monkey. J. Pharmacol. exp. Ther. 152, 383–387 (1966).
Garattini, S.: Personal communication (1966).
Greenblatt, E. N., and A. C. Osterberg: Some pharmacologic properties of thozalinone, a new excitant. Toxicol. appl. Pharmacol. 7, 556–578 (1965).
Hill, R. T., I. Koosis, M. W. Minor and E. B. Sibb: Potentiation of methylphenidate by imipramine, amitriptyline and their desmethyl analogues. Pharmacologist 3, 75 (1961).
Scheckel, C. L., and E. Boff: Behavioral effects of interacting imipramine and other drugs with d-amphetamine, cocaine, and tetrabenazine. Psychopharmacologia (Berl.) 5, 198–208 (1964).
Sigg, E. B.: Pharmacological studies with Tofranil. J. Canad. Psychiat. Ass. 4, Spec. Suppl. 75–83 (1959).
—, L. Gyermek, and R. T. Hill: Antagonism to reserpine induced depression by imipramine, related psychoactive drugs and some autonomic agents. Psychopharmacologia (Berl.) 7, 144–149 (1965).
Weissman, A.: Interaction effects of imipramine and d-amphetamine on nondiscriminated avoidance. Pharmacologist 3, 60 (1961).
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Bernstein, B.M., Latimer, C.N. Behavioral facilitation: The interaction of imipramine and desipramine with amphetamine, alpha-pipradrol, methylphenidate, and thozalinone. Psychopharmacologia 12, 338–345 (1968). https://doi.org/10.1007/BF00401412
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DOI: https://doi.org/10.1007/BF00401412