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The Biology and Functions of Th22 Cells

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T Helper Cell Differentiation and Their Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 841))

Abstract

T helper (Th) cells develop from naïve CD4+ T cells under lineage-specific culture conditions and are nominated by their lineage-specific cytokines. Th22 cells, new players in adoptive immune responses, are identified by the production of interleukin (IL)-22. Plenty of observations are obtained over the past few years indicating that IL-22 is produced by activated T cells including Th22 cells, Th17 cells, Th1 cells, innate lymphoid cells and some nonlymphocytes. IL-22 functions synergistically with IL-17 or tumor necrosis factor (TNF), however, it plays different roles by IL-22/IL-22 receptor signal transductions in pathologic processes, including inflammations, autoimmunity, tumor, and digestive organs damages. In this chapter, we focus on the biology of IL-22, the generation and regulation of Th22 cells, the possible signal pathways that involved in the functions of Th22 cells, as well as the relationship between Th22 cells and various diseases.

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Abbreviations

TNF:

Tumor necrosis factor

IL-TIF:

IL-10-related-T-cell-derived inducible factor

DC:

Dendritic cell

ILC:

Innate lymphoid cell

LTi cell:

Lymphoid tissue inducer cell

NCR:

Natural cytotoxicity triggering receptor

IL-22 BP:

IL-22 binding protein

AHR:

Aryl hydrocarbon receptor

CCR:

Chemokine receptor

CCL:

Chemokine ligand

SIRT:

Sirtuin

ROR:

Retinoic acid receptor-related orphan receptor

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  1. Key Laboratory of Tropical Disease Control Research of Ministry of Education, Zhongshan School of Medicine, Institute of Immunology, Sun Yat-Sen University, 74th, Zhongshan 2nd Road, Guangzhou, 510080, China

    Lei Jia & Changyou Wu

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  1. Lei Jia
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    Bing Sun

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Jia, L., Wu, C. (2014). The Biology and Functions of Th22 Cells. In: Sun, B. (eds) T Helper Cell Differentiation and Their Function. Advances in Experimental Medicine and Biology, vol 841. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9487-9_8

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