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Interplay between Metal Ions and Nucleic Acids pp 119–134Cite as

G-Quadruplexes and Metal Ions

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Part of the book series: Metal Ions in Life Sciences ((MILS,volume 10))

Abstract

Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.

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Acknowledgments

This work was supported by a CRUK Programme Grant to S. Neidle.

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Authors and Affiliations

  1. CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, UK

    Nancy H. Campbell & Stephen Neidle

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  1. Nancy H. Campbell
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  2. Stephen Neidle
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Correspondence to Stephen Neidle .

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Editors and Affiliations

  1. Inorganic Chemistry, Chemistry, Universität Basel, Spitalstr. 51, Basel, 4056, Basel Stadt, Switzerland

    Astrid Sigel

  2. Inorganic Chemistry, Chemistry, Universität Basel, Spitalstr. 51, Basel, 4056, Basel Stadt, Switzerland

    Helmut Sigel

  3. Organisch-Chemisches Institut, Universität Zürich, Winterthurerstrasse 190, Zürich, 8057, Switzerland

    Roland K. O. Sigel

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Campbell, N.H., Neidle, S. (2012). G-Quadruplexes and Metal Ions. In: Sigel, A., Sigel, H., Sigel, R. (eds) Interplay between Metal Ions and Nucleic Acids. Metal Ions in Life Sciences, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2172-2_4

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