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Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms

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Antineoplastic and Immunosuppressive Agents

Abstract

The isolation of estrone in 1929 independently by Doisy (1929) in the United States and by Butenandt (1929) in Germany made possible the classic experiment of Lacassagne (1932) in which mammary tumors in male mice were induced by giving injections of estrone. This experiment established a causal relationship between estrogenic hormones and mammary tumorigenesis. The proof that hormones can influence the growth of cancer was derived from experiments by Huggins and Clark (1940) on tumors of the prostate of the dog.

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  1. Thomas L. Dao
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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Dao, T.L. (1975). Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_11

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