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Transient Receptor Potential (TRP) Channels pp 363–375Cite as

TRPP2 Channel Regulation

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 179))

Abstract

Polycystin-2, or TRPP2 according to the TRP nomenclature, is encoded by PKD2, a gene mutated in patients with autosomal-dominant polycystic kidney disease. Its precise subcellular location and its intracellular trafficking are a matter of intense debate, although a consensus has emerged that it is located in primary cilia, a long-neglected organelle possibly involved in sensory functions. Polycystin-2 has a calculated molecular mass of 110 kDa, and according to structural predictions it contains six membrane-spanning domains and a pore-forming region between the 5th and 6th membrane-spanning domain. This section first introduces the reader to the field of cystic kidney diseases and to the PKD2 gene, before the ion channel properties of polycystin-2 are discussed in great detail.

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  1. Institute for Molecular and Cellular Anatomy, University of Regensburg, Universitätsstrasse 31, 93053, Regensburg, Germany

    R. Witzgall

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  1. R. Witzgall
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  1. Experimentele und Klinische, Pharmakologie und Toxikologie, Universität des Saarlandes, Gebäude 46, 66421, Homburg, Deutschland

    Veit Flockerzi

  2. Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, 3000, Leuven, België

    Bernd Nilius

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Witzgall, R. (2007). TRPP2 Channel Regulation. In: Flockerzi, V., Nilius, B. (eds) Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34891-7_22

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