Skip to main content

Abstract

The boundaries of endocrinology — like those of many disciplines — are fading. Most of the now known hormones were discovered in the course of this century, and they became the rewarding objects of investigations for those scientists who wanted to know what regulates their secretion, how they are transported, and by what mechanisms they act and are inactivated. But hormones also became drugs and thus were subjected to the rules of operation of the pharmaceutical industry and of those who study the effects and uses of drugs irrespective of their endocrine ancestry. One can deal with a synthetic steroid as one would with an alkaloid and one can modify its structure and build derivatives having more desirable combinations of activities than the natural parent substance — at least for the specific applications envisaged. But knowledge of the endocrine heritage helps.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. D. Achelis and K. Hardebeck, Dtsch. med. Wschr. 80, 1452 (1955).

    Google Scholar 

  2. W. M. Allen, Amer. J. Physiol. 92, 174 (1930).

    Google Scholar 

  3. E. B. Astwood, The Pharmacological Basis of Therapeutics (MacMillan Comp., New York 1966), p. 1466.

    Google Scholar 

  4. A. Bänder, W. Creutzfeldt, Th. Dorfmüller, H. Ehrhart, R. Marx, H. Maske, W. Meier, G. Mohnike, E. F. Pfeiffer, St. Schlagintweit, K. Schöffling, J. Scholz, I. Seidler, H. Steigerwald, W. Stich, G. Stötter and H. Ulrich, Dtsch. med. Wschr. 81, 823 and 887 (1956).

    Google Scholar 

  5. F. C. Bartter, I. H. Mills, E. G. Biglieri and C. Delea, Recent Progress in Hormone Research, 15 (Academic Press, New York 1959).

    Google Scholar 

  6. Th. J. Benraad and P. W. C. Kloppenborg, Clin. Chim. Acta 12, 565 (1965).

    Google Scholar 

  7. F. Bertram, E. Bendfeldt and H. Otto, Dtsch. med. Wschr. 80, 1455 (1955).

    Google Scholar 

  8. G. Bettendorf, M. Apostolakis and K. D. Voigt, Acta Endocrinol. [Copenhagen] 41, 1 (1962).

    Google Scholar 

  9. I. L. Bonta and C. J. de Vos, Acta endocrinol. [Copenhagen] 49, 403 (1965).

    Google Scholar 

  10. I. L. Bonta, C. J. de Vos and A. Delver, Acta Endocrinol. [Copenhagen] 48, 137 (1965).

    Google Scholar 

  11. P. Bouin and P. Ancel, J. Physiol. Path. gén. 12, 1 (1910).

    Google Scholar 

  12. W. J. van der Burg, D. A. van Dorp, O. Schindler, C. M. Siegmann and S. A. Szpilfogel, Recueil Trav. chim. Pays-Bas 77, 171 (1958).

    Google Scholar 

  13. W. R. Butt, A. C. Crooke and A. Wolf, Gonadotrophins: Physicochemical and Immunological Properties (J. and A. Churchill Ltd., London 1965), p. 85.

    Google Scholar 

  14. H. J. Buytendijk and Fr. Maesen, Acta Endocrinol. [Copenhagen] 47, 613 (1964).

    Google Scholar 

  15. B. Camerino and G. Sala, Progress in Drug Research 2, 71 (1960).

    Google Scholar 

  16. M. C. Chang, Endocrinology 63, 619 (1958).

    Google Scholar 

  17. J. B. Collip, Harvey Lectures 21, 113 (1925–1926).

    Google Scholar 

  18. J. W. Conn, The Evolution of Primary Aldosteronism from 1954 to 1960. First Internat. Congress of Endocrinology, Copenhagen (Periodica, Copenhagen 1960).

    Google Scholar 

  19. J. W. Conn, D. R. Rooner and E. L. Cohen, J. Amer. med. Assoc. 193, 200 (1965).

    Google Scholar 

  20. D. H. Copp, A. G. F. Davidson and B. A. Cheney, Proc. Canad. Fed. Biol. Soc. 4, 17 (1951).

    Google Scholar 

  21. A. C. Crooke, W. R. Butt, R. Morris and P. Palmer, Acta Endocrinol. [Copenhagen], Suppl. 67, 132 (1962).

    Google Scholar 

  22. A. Csapo, Recent Progress in Hormone Research, 13 (Academic Press, New York 1956).

    Google Scholar 

  23. A. Csapo, Progesterone (Brook Lodge Press, Augusta, Mich. 1961).

    Google Scholar 

  24. K. David, Acta brev. neerl. Physiol., Pharmacol., Microbiol, e.a. 5, 85 (1935).

    Google Scholar 

  25. K. David, E. Dingemanse, J. Freud and E. Laqueur, Hoppe Seyler’s Z. Physiol. Chem. 233, 281 (1935).

    Google Scholar 

  26. E. C. Dodds, L. Golberg, W. Lawson and R. Robinson, Nature [London] 142, 34 (1938).

    Google Scholar 

  27. R. A. Edgren, Acta Endocrinol. [Copenhagen] Suppl. 87 (1963).

    Google Scholar 

  28. G. Ehrhart, Naturwissenschaften 43, 93 (1956).

    Google Scholar 

  29. E. Eisenberg and G. S. Gordan, J. Pharmacol. exp. Therapeut. 99, 38 (1950).

    Google Scholar 

  30. J. W. Everett, Sex and Internal Secretions, Vol. 1 (The Williams and Wilkins Co., Baltimore 1961), p. 497.

    Google Scholar 

  31. J. Ferin and M. Renaer, to be published in Amer. J. Obstetr. Gynecol.

    Google Scholar 

  32. L. Fraenkel, Arch. Gynäkol. 68, 438 (1903).

    Google Scholar 

  33. H. Franke and J. Fuchs, Dtsch. med. Wschr. 80, 1449 (1955).

    Google Scholar 

  34. M. Friedman and L. Stimmler, Lancet, 1966 II, 944.

    Google Scholar 

  35. M. Friedman and Bl. B. Strang, Lancet, 1966 II, 568.

    Google Scholar 

  36. C. Gemzell, Ovulation (J. B. Lippincott Comp., Philadelphia 1966), p. 98.

    Google Scholar 

  37. E. Gerhards, H. Gibian and K. H. Koll, Arzneimittel-Forsch. 16, 458 (1966).

    Google Scholar 

  38. R. B. Greenblatt, Ovulation (J. B. Lippincott Comp., Philadelphia 1966), p. 134.

    Google Scholar 

  39. G. S. Greenwald, Fertil. and Steril. 12, 80 (1961).

    Google Scholar 

  40. J. Groen, C. E. Camminga, A. F. Willebrands and J. R. Blickman, J. Clin. Invest. 31, 97(1952).

    Google Scholar 

  41. J. Gross and R. Pitt-Rivers, Lancet 262, 593 (1952).

    Google Scholar 

  42. J. Gross and R. Pitt-Rivers, Lancet 262, 439 (1952).

    Google Scholar 

  43. J. Gross and R. Pitt-Rivers, Lancet 262, 1044 (1952).

    Google Scholar 

  44. H. M. Grundy, S. A. Simpson, J. F. Tait and M. Woodford, Acta Endocrinol. [Copenhagen] 11, 199 (1952).

    Google Scholar 

  45. K. Gutsche, A. Harwart, H. Horstmann, H. Priewe, G. Raspé, E. Schraufstätter, S. Wirtz and U. Wörffel, Arzneimittel-Forsch. 14, 373 (1964).

    Google Scholar 

  46. H. D. Hagedorn, B. N. Jensen, N. B. Krarup and I. Woodstrup, J. Amer. med. Assoc. 106, 177 (1936).

    Google Scholar 

  47. K. Hallas-Moller, M. Jersild, K. Petersen and J. Schlichtkrull, J. Amer. med. Assoc. 150, 1667 (1952).

    Google Scholar 

  48. P. S. Hench, E. C. Kendall, C. H. Slocumb and H. F. Polley, Prof. Staff Meetings Mayo Clinic 24, 181 (1949).

    Google Scholar 

  49. P. S. Hench, C. H. Slocumb, H. F. Polley and E. C. Kendall, J. Amer. med. Assoc. 144, 1327 (1950).

    Google Scholar 

  50. L. G. Hershberger, E. G. Shipley and R. K. Meyer, Proc. Soc. Exp. Biol. Med. 83, 175 (1953).

    Google Scholar 

  51. R. Hertz, W. Tullner and E. Raffelt, Endocrinology 54, 228 (1954).

    Google Scholar 

  52. H. L. Herzog, A. Nobile, S. Tolksdorf, W. Charney, E. B. Hershberg, P. L. Perlman and M. M. Pechet, Science 121, 176 (1955).

    Google Scholar 

  53. P. F. Hirsch, G. F. Gauthier and P. L. Munson, Endocrinology 73, 244 (1963).

    Google Scholar 

  54. K. Hofmann, H. Yajime, N. Yanaihara, T. Liu and S. Lande, J. Amer. Chem. Soc. 83, 487 (1961).

    Google Scholar 

  55. J. D. H. Homan, G. A. Overbeek, J. P. J. Neutelings, C. J. Booy and J. van der Vies, Lancet 266, 541 (1954).

    Google Scholar 

  56. P. Jacobson, A.M.A. Arch. Otolaryng. 59, 523 (1954).

    Google Scholar 

  57. H. H. Inhoffen and W. Hohlweg, Naturwissenschaften 26, 96 (1938).

    Google Scholar 

  58. M. Janbon, J. Chaptal, A. Vedel and J. Schaap, Montpellier méd. 21–22, 441 (1942).

    Google Scholar 

  59. F. A. Kincl, Methods in Hormone Research, Vol. 4 (Academic Press, New York 1965).

    Google Scholar 

  60. F. A. Kincl and R. I. Dorfman, Acta Endocrinol. [Copenhagen] Suppl. 73 (1963).

    Google Scholar 

  61. B. Kliman and R. E. Petersen, J. Biol. chem. 235, 1639 (1960).

    Google Scholar 

  62. P. W. C. Kloppenborg, Thesis, Nijmegen (1966).

    Google Scholar 

  63. H. H. Knaus, Arch. Gynäkol. 138, 201 (1929).

    Google Scholar 

  64. C. D. Kochakian, Conference on Metabolic Aspects of Convalescence. Josiah Macy Jr. Foundation, 16th Meeting, New York (1947).

    Google Scholar 

  65. H. L. Krüskemper, Anabole Steroide (Georg Thieme, Stuttgart 1963).

    Google Scholar 

  66. A. Lardon, O. Schindler and T. Reichstein, Helv. Chim. Acta 40, 666 (1957).

    Google Scholar 

  67. V. Laschet, L. Laschet and H. F. Paarmann, Arzneimittel-Forsch. 16, 469 (1966).

    Google Scholar 

  68. T. H. Lee, A. B. Lerner and V. Buettner-Janusch, J. biol. Chemistry 236, 2970 (1961).

    Google Scholar 

  69. C. H. Li, J. J. Geschwind, R. D. Cole, J. D. Raacke, J. Harris and J. S. Dixon, Nature [London] 176, 687 (1955).

    Google Scholar 

  70. C. H. Li, J. S. Dixon and D. Chung, J. Amer. chem. Soc. 80, 2587 (1958).

    Google Scholar 

  71. A. Loubatières, Ann. N.Y. Acad. Sci. 71, 4 (1957).

    Google Scholar 

  72. A. Loubatières, C. r. Séances Soc. Biol. Filiales 138, 766 (1944).

    Google Scholar 

  73. G. B. Lunenfeld and P. Donini, Ovulation (J. B. Lippincott Comp., Philadelphia 1966), p. 105.

    Google Scholar 

  74. I. MacIntyre, G. V. Foster and M. A. Kumar, The Parathyroid Glands (University of Chicago Press, Chicago 1965), p. 89.

    Google Scholar 

  75. Z. Madjerek, J. de Visser, J. van der Vies and G. A. Overbeek, Acta Endocrinol. [Copenhagen] 35, 8 (1960).

    Google Scholar 

  76. A. W. Makepeace, G. L. Weinstein and M. H. Friedman, Amer. J. Physiol. 119, 512 (1937).

    Google Scholar 

  77. D. B. Martin, A. E. Renold and Y. M. Dagenais, Lancet 1958 II, 76.

    Google Scholar 

  78. G. Mayer, Les fonctions de nidation utérine et leurs troubles, Colloque de la Société Nationale pour l’étude de la stérilité et de la fécondité (Masson et Cie., Paris 1960), p. 1–32.

    Google Scholar 

  79. The Menopause and the Role of Estrogens. Round Table Conference (Excerpta Medica, Amsterdam 1962).

    Google Scholar 

  80. P. L. Munson and P. F. Hirsch, Clinical orthop. 49, 209 (1966).

    Google Scholar 

  81. F. Neumann, Acta Endocrinol. [Copenhagen] 53, 382 (1966).

    Google Scholar 

  82. F. Neumann and R. Wiechert, Arzneimittel-Forsch. 15, 1168 (1965).

    Google Scholar 

  83. F. Neumann, R. Wiechert, M. Kramer and G. Raspé, Arzneimittel-Forsch. 16, 455 (1966).

    Google Scholar 

  84. H. Nowakowski and H. P. Schmidt, Med. Klin. 61, 223 (1966).

    Google Scholar 

  85. G. A. Overbeek, Anabole Steroide, Chemie und Pharmakologie (Springer Verlag, Heidelberg 1966).

    Google Scholar 

  86. G. A. Overbeek, A. Delver and J. de Visser, Acta Endocrinol. [Copenhagen] 63, 7 (1961).

    Google Scholar 

  87. G. Pincus, The Control of Fertility (Academic Press, New York and London 1965).

    Google Scholar 

  88. R. Pitt-Rivers and J. R. Tata, The Thyroid Hormones (Pergamon Press, London 1959).

    Google Scholar 

  89. H. Poliwoda, H. Schmidt-Matthiesen and M. Bartels, Schweiz. med. Wschr. 93, 1568 (1963).

    Google Scholar 

  90. J. T. Potts Jr., Proceedings Third Parathyroid Conference, Montreal 1967 (Excerpta Medica, Amsterdam) (to be published).

    Google Scholar 

  91. J. T. Potts, G. D. Aurbarch and L. M. Sherwood, Recent Progr. Hormone Res. 22, 101 (1966).

    Google Scholar 

  92. A. Puck, W. Korte and K. A. Hübner, Dtsch. med. Wschr. 82, 1964 (1957).

    Google Scholar 

  93. A. Psychoyos, Egg Implantation, Ciba Foundation Study Group, No. 23 (J. and A. Churchill Ltd., London 1966).

    Google Scholar 

  94. P. J. Randle, On the Nature and Treatment of Diabetes (Excerpta Medica Foundation, Amsterdam 1965), Internat. Congress Series, No. 84, p. 361.

    Google Scholar 

  95. R. J. Randle, P. B. Garland, C. N. Hales and E. A. Newsholme, Lancet 1963 I, 785.

    Google Scholar 

  96. P. Roos and C. A. Gemzell, Gonadotrophins: Physicochemical and Immunological Properties. Ciba Foundation Study Group, No. 22 (J. and A. Churchill Ltd., London (1965), p. 11.

    Google Scholar 

  97. H. W. Rudel and F. A. Kincl, Acta Endocrinol. [Copenhagen] Suppl. 105 (1966).

    Google Scholar 

  98. L. Ruzicka and A. Wettstein, Helv. chim. Acta 18, 986 (1935).

    Google Scholar 

  99. L. Ruzicka and A. Wettstein, Helv. chim. Acta 18, 1264 (1935).

    Google Scholar 

  100. L. H. Sarett, A. A. Patchett and S. Steelman, Progress in Drug Research 5, 11 (1963).

    Google Scholar 

  101. C. Schirren, Arzneimittel-Forsch. 16, 463 (1966).

    Google Scholar 

  102. M. Schiff and H. F. Burn, A.M.A. Arch. Otolaryng. 63, 43 (1961).

    Google Scholar 

  103. J. Schlichtkrull, J. Funder and O. Munk, Endocrinologiae Progressus. Proceedings of the First European Colloquium in Endocrinology, Playa de Aro (1961), p. 683.

    Google Scholar 

  104. J. Schmidlin, G. Anner, J. R. Billiter and A. Wettstein, Experientia [Basel] 11, 365 (1955).

    Google Scholar 

  105. H. Schmidt-Matthiesen and H. Poliwoda, Arch. Gynäk. 200, 231 (1965).

    Google Scholar 

  106. R. Schwyzer and P. Sieber, Nature [London] 199, 172 (1963).

    Google Scholar 

  107. H. Selye, Annual Report on Stress (Acta Inc. Medical Publishers, Montreal, Canada 1951).

    Google Scholar 

  108. H. Selye, The Physiology and Pathology of Exposure to Stress (Acta Inc. Medical Publishers, Montreal, Canada 1950).

    Google Scholar 

  109. G. W. G. Sharp, Recent Progr. Hormone Res. 22, 431 (1966).

    Google Scholar 

  110. R. G. Shepherd, K. S. Howard and P. H. Bell, J. Amer. Chem. Soc. 78, 5051 (1956).

    Google Scholar 

  111. S. A. Simpson, J. F. Tait, A. Wettstein, R. Neher, J. von Euw, O. Schindler and T. Reichstein, Experientia [Basel] 10, 132 (1954).

    Google Scholar 

  112. J. Sterne, Metabolism clin. exp. 13, 791 (1964).

    Google Scholar 

  113. H. Strausser, Studies on the Development and Application of a Modified Haemagglutination Procedure. Thesis New Brunswick 1958, Dissertation Abstr. 20, 450 (1959).

    Google Scholar 

  114. D. Taft, G. Shyamala and J. Gorski, Proc. Nat. Acad. Sci. USA 57, 1740 (1967).

    Google Scholar 

  115. M. Tausk, Het Hormoon 15, 173 (1951).

    Google Scholar 

  116. M. Tausk, Europ. Rev. Endocrin. [Oxford] Suppl. 2, part 2, 419 (1967).

    Google Scholar 

  117. G. Ungar, L. Freedman and S. L. Shapiro, Proc. Soc. Exp. Biol. Med. 93, 190 (1957).

    Google Scholar 

  118. J. van der Vies, Acta Endocrinol. [Copenhagen] 49, 111 (1965).

    Google Scholar 

  119. Th. Wainman and G. C. Shipounoff, Endocrinology 29, 975 (1941).

    Google Scholar 

  120. R. G. A. van Wayjen and G. Buyze, Acta Endocrinol. [Copenhagen] Suppl. 63 (1962).

    Google Scholar 

  121. O. Weller, Arzneimittel-Forsch. 12, 234 (1962).

    Google Scholar 

  122. O. Weller, Endokrinologie 41, 60 (1961).

    Google Scholar 

  123. O. Weller, Arzneimittel-Forsch. 16, 465 (1966).

    Google Scholar 

  124. L. Wide and C. A. Gemzell, Acta Endocrinol. [Copenhagen] 35, 261 (1960).

    Google Scholar 

  125. L. Wide, Acta Endocrinol. [Copenhagen] 41, Suppl. 70 (1962).

    Google Scholar 

  126. R. Wiechert, H. Steinbeck, W. Elger and F. Neumann, Arzneimittel-Forsch. 17, 1103 (1967).

    Google Scholar 

  127. R. S. Yalow and S. A. Berson, J. Clin. Invest. 39, 1157 (1960).

    Google Scholar 

  128. R. A. Wilson, R. E. Brevetti and Th. A. Wilson, West. J. Surg. Obstet. Gvnecol. 71, 110 (1963).

    Google Scholar 

  129. R. A. Wilson, Feminine Forever (McEvans Co. Inc., New York 1966).

    Google Scholar 

  130. M. S. de Winter, C. M. Siegmann and S. A. Szpilfogel, Chem. Ind. [London] 1959, 905.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1968 Springer Basel AG

About this chapter

Cite this chapter

Tausk, M. (1968). Practically Applicable Results of Twenty Years of Research in Endocrinology. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques, vol 12. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7065-8_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7065-8_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7067-2

  • Online ISBN: 978-3-0348-7065-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics