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Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour

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Galanin

Part of the book series: Experientia Supplementum ((EXS,volume 102))

Abstract

The pathophysiology of depression remains unclear, but involves disturbances in brain monoaminergic transmission. Current antidepressant drugs, which act by enhancing this type of neurotransmission, have limited therapeutic efficacy in a number of patients, and also cause serious side-effects, which limits their compliance. Increasing evidence suggests that neuropeptides, including galanin, can be of relevance in mood disorders. Galanin is co-expressed with and modulates noradrenaline and serotonin transmission, both implicated in depression. Pharmacological and genetic studies suggest a role for galanin in depression-like behaviour in rodents, involving specific receptor subtypes. Thus, stimulation of GalR1 and/or GalR3 receptors results in depression-like phenotype, while activation of the GalR2 receptor reduces depression-like behaviour in the rat. These findings suggest that galanin receptor subtypes may represent novel targets for the development of antidepressant drugs.

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Acknowledgments

Dr. E. Kuteeva is supported by a post-doctoral fellowship from the Swedish Brain Foundation. This work was supported by The Swedish Research Council (11588, 2887), The Marianne and Marcus Wallenberg Foundation, Wallenberg Consortium North, an EC Grant (NEWMOOD; LHSM-CT-2003-503474), The Swedish Brain Foundation, Karolinska Institutet Funds, Svenska Lundbeckstiftelsen, Stiftelsen Goljes Minne and Stiftelsen Ragnhild och Einar Lundströms Minne.

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  1. Department of Neuroscience, Karolinska Institutet, Retzius väg. 8, 171 77, Stockholm, Sweden

    Eugenia Kuteeva, Tomas Hökfelt, Tara Wardi & Sven Ove Ögren

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  1. Eugenia Kuteeva
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  2. Tomas Hökfelt
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  3. Tara Wardi
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  4. Sven Ove Ögren
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Correspondence to Sven Ove Ögren .

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  1. Dept. Neuroscience, Karolinska Institute, Retzius vaeg 8, Stockholm, 171 77, Sweden

    Tomas Hökfelt

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Kuteeva, E., Hökfelt, T., Wardi, T., Ögren, S.O. (2010). Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour. In: Hökfelt, T. (eds) Galanin. Experientia Supplementum, vol 102. Springer, Basel. https://doi.org/10.1007/978-3-0346-0228-0_12

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