Abstract
There is a growing awareness of the role of tropomyosin in the regulation of the actin filament. Work in the field is increasingly directed at understanding the mechanisms of function at both a molecular and atomic level and developing therapeutic strategies to treat tropomyosin-based pathology. This chapter highlights unresolved issues that cross the boundaries between individual chapters and are likely to be fertile areas of research in the future.
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Alberts B, Bray D, Lewis J et al. Molecular Biology of the Cell, 3rd Ed. Garland Publishing Inc., New York: 1994; Fig 16–79.
Ayscough KR. In vivo functions of actin-binding proteins. Curr Opin Cell Biol 1998; 10:102–111.
Craig SW, Pardo JV. Gamma actin, spectrin and intermediate filament proteins colocalize with vinculin at costameres, myofibril-to-sarcolemma attachment sites. Cell Motil 1983; 3:449–462.
Kee AJ, Schevzov G, Nair-Shalliker V et al. Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy. J Cell Biol 2004; 166:685–696.
Lubit BW. Association of beta-cytoplasmic actin with high concentrations of acetylcholine receptor (AChR) in normal and anti-AChR-treated primary rat muscle cultures. J Histochem Cytochem 1984; 32:973–981.
Schevzov G, Lloyd C, Hailstones D et al. Differential regulation of tropomyosin isoform organisation and gene expression in response to altered actin gene expression. J Cell Biol 1993; 121:811–821.
Wong K, Wessels D, Krob SL et al. Forced expression of a dominant-negative chimeric tropomyosin causes abnormal motile behaviour during cell division. Cell Motil Cytoskel 2000; 45:121–132.
Vlahovich N, Schevzov G, Nair-Shalliker V et al. Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and disease muscle. Cell Motil Cytoskel 2008; 65:73–85.
Houle F, Rousseau S, Morrice N et al. Extracellular signal-regulated kinase mediates phosporylation of tropomyosin-1 to promote cytoskeleton remodelling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell 2003; 14:1418–1432.
Naga Prasad SV, Jayatilleke A, Madamanchi A et al. Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. Nat Cell Biol 2005; 7:785–796.
Somara S, Pang H, Bitar KN. Agonist-induced association of tropomyosin with the protein kinase C-α in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 2005; 288:G268–G276.
Gunning P, O’Neill G, Hardeman E. Tropomyosin-based regulation of the actin cytoskeleton in time and space. Physiol Rev 2008; 88:1–35.
Lehman W, Hatch V, Korman V et al. Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. J Mol Biol 2000; 302:593–606.
Prasad GL, Fuldner RA, Cooper HL. Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene. Proc Natl Acad Sci USA 1993; 90:7039–7043.
Boyd J, Risinger JI, Wiseman RW et al. Regulation of microfilament organization and anchorage-independent growth by tropomyosin1. Proc Natl Acad Sci USA 1995; 92:11534–11538.
Gimona M, Kazzaz JA, Helfman DM. Forced expression of tropomyosin 2 or 3 in v-ki-ras-transformed fibroblasts results in distinct phenotypic effects. Proc Natl Acad Sci USA 1996; 93:9618–9623.
O’Neill GM, Stehn J, Gunning PW. Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton. Seminars Cancer Biol 2008; 18:35–44.
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© 2008 Landes Bioscience and Springer Science+Business Media
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Gunning, P. (2008). Emerging Issues for Tropomyosin Structure, Regulation, Function and Pathology. In: Gunning, P. (eds) Tropomyosin. Advances in Experimental Medicine and Biology, vol 644. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85766-4_22
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DOI: https://doi.org/10.1007/978-0-387-85766-4_22
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-85765-7
Online ISBN: 978-0-387-85766-4
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