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Immunization Strategies Against Henipaviruses

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Book cover Henipavirus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 359))

Abstract

Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

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Acknowledgments

The views expressed in the manuscript are solely those of the authors, and they do not represent official views or opinions of the Department of Defense or The Uniformed Services University of the Health Science. Supported in part by the Department of Health and Human Services, National Institutes of Health, grants AI054715, AI077995, AI082121.

Conflict of Interest

C.C.B is a United States federal employee; C.C.B is coinventor on patents relating to human monoclonal antibodies against Hendra and Nipah viruses and C.C.B and K.N.B are coinventors on patents relating to soluble forms of Hendra and Nipah envelope glycoproteins and vaccines; assignees are The United States of America as represented by the Department of Health and Human Services (Washington, DC), and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, MD). All other authors declare no competing interests.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, 20814, USA

    Christopher C. Broder

  2. Galveston National Laboratory and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77550, USA

    Thomas W. Geisbert

  3. Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA

    Kai Xu & Dimitar B. Nikolov

  4. CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC, 3220, Australia

    Lin-Fa Wang, Deborah Middleton & Jackie Pallister

  5. Department of Microbiology, Boston University School of Medicine, Boston, MA, 02118, USA

    Katharine N. Bossart

  6. National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, MA, 02118, USA

    Katharine N. Bossart

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  1. Christopher C. Broder
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  2. Thomas W. Geisbert
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  3. Kai Xu
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  4. Dimitar B. Nikolov
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  5. Lin-Fa Wang
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  6. Deborah Middleton
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  7. Jackie Pallister
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  8. Katharine N. Bossart
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Correspondence to Christopher C. Broder .

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Editors and Affiliations

  1. , Dept. of Microbiol., Immunol., Mol. Gen., David Geffen School of Medicine, Charles E. Young Drive East 615, Los Angeles, 90095-1489, California, USA

    Benhur Lee

  2. MS-C-22, 1600 Clifton Road, Atlanta, 30329, Georgia, USA

    Paul A. Rota

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© 2012 Springer-Verlag Berlin Heidelberg

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Broder, C.C. et al. (2012). Immunization Strategies Against Henipaviruses. In: Lee, B., Rota, P. (eds) Henipavirus. Current Topics in Microbiology and Immunology, vol 359. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_213

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