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Chemical Activation of Sensory TRP Channels

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Taste and Smell

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 23))

Abstract

The overall perception of flavor results from the integration of taste, smell, and somatosensory information streaming out of specialized receptor cells located in the oronasal cavities. Several members of the transient receptor potential family of cation channels contribute to the signal transduction of chemical stimuli. All bona fide TRP channel chemosensors contribute to flavor detection by acting on epithelial cells and/or sensory nerve endings in the mucosa of the nose, mouth, and throat. Chemical activation of these channels results in a very obvious, but yet obscure, sensory modality called trigeminality or chemesthesis, which is related to the perception of texture, temperature, and pungency. These sensations arise when chemical compounds activate receptor cells associated with other senses that mediate touch, thermal perception, and pain. In this chapter we illustrate the huge diversity of chemical agonists of TRP channels and underscore the need of more basic research on this amazing family of molecular sensors, which are very likely to hold the key for better understanding of human sensory pathophysiology.

Brett Boonen and Justyna B. Startek are equally contributed to this work.

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Acknowledgments

This work was supported by grants from the Research Council of the KU Leuven (OT/12/091, GOA/14/011, EF/95/010, and PF-TRPLe) and the Flemish Research Foundation (FWO, G.0702.12, G.0896.12, G.0765.13, and G.0C77.15 N).

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    Authors and Affiliations

    1. Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), KU Leuven, Herestraat 49, Campus Gasthuisberg O&N1 bus 802, 3000, Leuven, Belgium

      Brett Boonen, Justyna B. Startek & Karel Talavera

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    1. Brett Boonen
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    2. Justyna B. Startek
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    3. Karel Talavera
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    Correspondence to Karel Talavera .

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    1. Deutsche Forschungsanstalt fuer Lebensmittelchemie, Leibniz Institut, Freising, Germany

      Dietmar Krautwurst

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    Boonen, B., Startek, J.B., Talavera, K. (2016). Chemical Activation of Sensory TRP Channels. In: Krautwurst, D. (eds) Taste and Smell. Topics in Medicinal Chemistry, vol 23. Springer, Cham. https://doi.org/10.1007/7355_2015_98

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