Regular ArticleBiosynthesis of interleukin-6, an autocrine growth factor for melanoma, is regulated by melanoma-derived histamine
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2018, Journal of Immunological MethodsCitation Excerpt :IL-6 stands out in functioning as pro-tumor rather than anti-tumor cytokine possibly through an indirect mechanism such as causing the expansion of myeloid-derived suppressor cells (Diaz-Montero et al., 2014). With its direct effects, IL-6 has been shown as a growth factor for melanoma (Lu et al., 1996; Molnár et al., 2000). In correlation, a previous report suggested that melanoma patients with high serum IL-6 have a shorter survival and a tendency to be resistant to non-specific immunotherapy with IL-2 (Tartour et al., 1994).
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