Regular Article
Biosynthesis of interleukin-6, an autocrine growth factor for melanoma, is regulated by melanoma-derived histamine

https://doi.org/10.1006/scbi.2000.0304Get rights and content

Abstract

Interleukin-6 is an autocrine growth factor in advanced stage melanoma and biosynthesis of IL-6 is increased by histamine in various cell lines. In our study we analysed the direct relation of histamine and IL-6 synthesis in human melanoma cell lines. All melanoma cells contained IL-6 mRNA, but only metastatic melanoma cells secreted the IL-6 protein. The H1 histamine receptor antagonist triprolidine decreased gene expression and biosynthesis of IL-6, while other histamine receptor antagonists had no effect. These data indicate that endogenous histamine has a definite role in the regulation of local IL-6, suggesting that histamine and IL-6 could be part of autocrine growth regulation of the tumor.

References (18)

There are more references available in the full text version of this article.

Cited by (21)

  • Proteomic profiles by multiplex microsphere suspension array

    2018, Journal of Immunological Methods
    Citation Excerpt :

    IL-6 stands out in functioning as pro-tumor rather than anti-tumor cytokine possibly through an indirect mechanism such as causing the expansion of myeloid-derived suppressor cells (Diaz-Montero et al., 2014). With its direct effects, IL-6 has been shown as a growth factor for melanoma (Lu et al., 1996; Molnár et al., 2000). In correlation, a previous report suggested that melanoma patients with high serum IL-6 have a shorter survival and a tendency to be resistant to non-specific immunotherapy with IL-2 (Tartour et al., 1994).

View all citing articles on Scopus
2

Corresponding author.

View full text