Regular ArticlePOSSIBLE PROTECTIVE EFFECT OF MELATONIN AND/OR DESFERRIOXAMINE AGAINST STREPTOZOTOCIN-INDUCED HYPERGLYCAEMIA IN MICE☆
References (26)
- et al.
Mechanism of oxidant-mediated cell injury: the glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide
J Biol Chem
(1988) - et al.
Pharmacological actions of melatonin in oxygen radical pathophysiology
Life Sci
(1997) - et al.
Role of free radicals and catalytic metal ions in human disease: an overview
Methods Enzymol
(1990) - et al.
The effects of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rats
Free Radic Biol Med
(1995) - et al.
Lithium chloride enhances survival of NZB/W lupus mice: Influence of melatonin and timing of treatment
Int J Immunopharmacol
(1995) - et al.
Determination of malon- aldehyde precursor in tiss ues by thiobarbituric acid test
Anal Biochem
(1978) Free radicals and diabetes
Free Radic Biol Med
(1988)- et al.
Lipoperoxidos en la diabetes por estreptozotocina en ratas: Effects de la administracion de insulina
Clin Invest Arterioscler
(1998) Role of oxidative stress in development of complications in diabetes
Diabetes
(1991)- et al.
Hydroxyl radical production and autoxidative glycosylation: Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and aging
J Biochem
(1988)
Glycation of insulin in the islets of Langerhans of normal and diabetic animals
Diabetes
Oxidative stress and diabetic vascular complications
Diabetes Care
Cited by (55)
Influence of Sterculia setigera Delile extract on oxidative stress enzyme activity and treatment of impaired glucose homeostasis in Streptozotocin-induced diabetic Wistar rats
2023, Pharmacological Research - Modern Chinese MedicineCombined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats
2018, Life SciencesCitation Excerpt :Some studies have demonstrated that melatonin reduces hyperglycemia and hyperlipidemia in STZ-induced diabetic animals and the hiperinsulinemia in Otsuka Long-Evans Tokushima Fatty (OLEFT) animals [12]. Additionally, melatonin treatment of diabetic animals reduced glycemia in comparison to non-treated animals [13]. On the other hand, another study demonstrated that diabetic animals treated with melatonin via intraperitoneal injections did not present reduced glycemic levels [14].
Effect of Melatonin as an Antioxidant in the Liver
2018, The Liver: Oxidative Stress and Dietary AntioxidantsAttenuation of acute and chronic liver injury by melatonin in rats
2013, Journal of Taibah University for ScienceCitation Excerpt :Antioxidants can help to minimize the oxidative stress, in cirrhotic livers [24]. Melatonin (N-acetyl-5-metyoxytryptamine) is a powerful endogenous antioxidant, plays very important roles in regulation of circadian rhythms, sleep, immune system activity, and elimination of oxygen free radicals [25,26], and exerts its antioxidant effects mainly through G protein dependent receptors which lead to the induction of antioxidant enzyme synthesis [27]. In this way, melatonin neutralizes the effects of both oxygen- and nitrogen-based reactive molecules [28].
Potential therapeutic value of melatonin in diabetic nephropathy: improvement beyond anti-oxidative stress
2023, Archives of Physiology and Biochemistry
- ☆
Unspecified