Regular ArticlesBrucella abortus siderophore2,3-dihydroxybenzoic acid (DHBA) facilitatesintracellular survival of the bacteria
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Cited by (43)
Erythritol triggers expression of virulence traits in Brucella melitensis
2013, Microbes and InfectionCitation Excerpt :If erythritol is able to stimulate the growth of B. melitensis in broth culture, it was interesting that it did not also stimulate bacterial growth inside of macrophages [27]. Previous work examining the effect of erythritol additions to the cell culture medium on intracellular B. abortus within bovine trophoblasts also found that erythritol was inhibitory to intracellular growth, although growth with erythritol in the culture medium was never compared to growth without erythritol [28]. In B. abortus, it was hypothesized that this intracellular growth defect in the presence of erythritol was due to the fact that iron played an important role in erythritol utilization, and iron may be limited in availability within the Brucella intracellular compartment [29,30].
Monocyte-derived macrophages from Zebu (Bos taurus indicus) are more efficient to control Brucella abortus intracellular survival than macrophages from European cattle (Bos taurus taurus)
2013, Veterinary Immunology and ImmunopathologyCitation Excerpt :Under iron limiting conditions, Gram-negative bacteria release iron chelating agents with low molecular weight and high affinity called siderophores (Neilands, 1992). B. abortus has two known siderophores, the 2,3-dihydroxybenzoic acid (2,3-DHBA) (encoded by the dhbCEBA operon) and brucebactin (Bellaire et al., 2003a,b; Lopez-Goñi et al., 1992; Martínez et al., 2006; Parent et al., 2002). Our results demonstrated that B. abortus ΔdhbC was attenuated in bovine macrophages from both breeds and this phenotype was exacerbated under intralysosomal iron depletion.
The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages
2010, Microbes and InfectionCitation Excerpt :In agreement with the crucial role of the siderophore system in intra- and extracellular growth function siderophore biosynthetic genes such as sidA, sidC, sidD and sidF are expressed in vivo during the onset of an infection [30] and sidD is more prominently expressed in a macrophage cell line compared to sidC, but both are expressed in media containing serum [31]. Numerous studies prove the essentiality of extracellular siderophores for bacterial growth inside macrophages e.g. salicylate-derived mycobactin of Mycobacterium tuberculosis [32], anthrachelin of Bacillus anthracis [33], and 2,3-dihydroxybenzoic of Brucella abortus [34], but bacteria do not possess intracellular siderophores. Furthermore, treatment of macrophages with desferroxamine inhibited the intracellular conidium-to-yeast transformation of Paracoccidioides brasiliensis [35].
Accumulation of isochorismate-derived 2,3-dihydroxybenzoic 3-O-β-D-xyloside in Arabidopsis resistance to pathogens and ageing of leaves
2010, Journal of Biological ChemistryCitation Excerpt :At lower concentrations, 2,3-DHBA might protect the plant cell from oxidative stress because this is a function of 2,3-DHBA produced by bacterial pathogens infecting mammals. By acting as an iron siderophore, 2,3-DHBA is thought either to prevent the formation of the reactive hydroxyl radical generated in the presence of free iron and hydrogen peroxide (the Fenton reaction) that is harmful to the pathogen or to help acquire limited iron resources from the host cell and thus facilitate pathogen growth (70–72). The 2,3-DHBA we detect in planta upon increasing plant age might thus also serve as a protectant against oxidative stress associated with senescence (73).
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