Regular ArticleThe Effect of Sepsis on Wound Healing☆
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2023, Current Therapy of Trauma and Surgical Critical CareThe risk of pressure ulcers in a proned COVID population
2022, SurgeonCitation Excerpt :Ulceration and tissue damage are common in this COVID population due to the prone positioning and use of medical devices to assist and supplement care. The use of vasopressors reduces peripheral tissue perfusion, and wound healing potential significantly decreases due to the systemic inflammatory response.8 Pre-existing preventative and management strategies include regular repositioning, correct mattresses and pressure redistribution, however gel pads and high-specification mattresses were in short supply due to unprecedented demand.
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2016, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Mice depleted of monocytes/macrophages died from cardiac rupture and atherothrombosis [30] and MI induced in atherosclerotic mice impaired healing [31]. Importantly, healing in human patients is also impaired under both strongly inflammatory (chronic ulcers: [32], sepsis: [33]) as well as under immunosuppressed (corticosteroids: [34]) conditions. This demonstrates the importance of early inflammation and the need for a balanced and coordinated response for successful healing.
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This work was supported by the Dr. Ralph and Marion C. Falk Medical Research Trust (L.A.D., R.L.G.) and National Institutes of Health Grants GM55238 (L.A.D.) and GM42577 (R.L.G.).
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To whom correspondence and reprint requests should be addressed at Loyola University Medical Center, Burn and Shock Trauma Institute, 2160 S. First Avenue, Maywood, IL 60153. Fax: (708) 327-2813. E-mail: [email protected].