Journal of Molecular Biology
Regular articleGenetically Unstable CXG Repeats are Structurally Dynamic and Have a High Propensity for Folding. An NMR and UV Spectroscopic Study
References (0)
Cited by (86)
Length-independent and selective sensing of CCG trinucleotide repeat foldings by a monovalency-binding fluorogenic probe
2024, Sensors and Actuators B: ChemicalSelectively recognizing extrahelical conformations of DNA trinucleotide repeats by a hydroxylated porphyrin ligand
2022, Analytica Chimica ActaCitation Excerpt :Therefore, according to the results of intermolecular and intramolecular DNA structures, we expected that the sequences beyond TRs did not compromise the E-motif recognition by POH3 in spite of the modified binding energies. The bare 5′-CCG-3′ repeats without the terminal base-pair constraints are reported to preferably form the E-motif structures in contrast to the bare 5′-GCC-3′ repeats, precisely the polarity-inverted counterparts [13,15,19–22]. This polarity-dependent particularity is supported by strand slippage during forming the stable homoduplex/hairpin structures and is conversely opposed to the above investigated TRs having the terminal base pair constraints.
Stability of the pH-Dependent Parallel-Stranded d(CGA) Motif
2020, Biophysical JournalCitation Excerpt :In contrast, the two-state profile for longer repeat sequences (n ≥ 6) suggests they exist predominantly in the hairpin conformation. This trend is similar to the length-dependent conformational equilibrium seen in other triplet repeats (25) and further supports the importance of oligo lengths in rational structure design. To estimate the energetic contribution of each parallel-stranded triplet unit, we compared thermodynamic parameters of oligonucleotides with a differing number of repeat units.
A small unstructured nucleic acid disrupts a trinucleotide repeat hairpin
2011, Biochemical and Biophysical Research CommunicationsNon-B conformations of CAG repeats using 2-aminopurine
2011, Methods in Enzymology